Continuing the Dialog on Human-Animal Chimerism: Response to Bolo, Wills, and Maschke [0.03%]
人兽嵌合体对话的延续：对Bolo、Wills和Maschke的回答回应
Andrew T Crane,Francis X Shen,Walter C Low
Andrew T Crane
Public Attitudes toward Human-Animal Chimera Research May Be More Complicated than They Appear [0.03%]
公众对人兽嵌合体研究的态度可能比看起来的要复杂得多
Isabel Bolo,Ben Curran Wills,Karen J Maschke
Isabel Bolo
Derivation of Peripheral Nociceptive, Mechanoreceptive, and Proprioceptive Sensory Neurons from the same Culture of Human Pluripotent Stem Cells [0.03%]
人多能干细胞分化为外周伤害性、机械性和本体感觉神经元
Kenyi Saito-Diaz,Jonathan Roy Street,Heidi Ulrichs et al.
Kenyi Saito-Diaz et al.
The three peripheral sensory neuron (SN) subtypes, nociceptors, mechanoreceptors, and proprioceptors, localize to dorsal root ganglia and convey sensations such as pain, temperature, pressure, and limb movement/position. Despite previous re...
Generation of Human-Induced Pluripotent Stem Cell-Derived Functional Enterocyte-Like Cells for Pharmacokinetic Studies [0.03%]
人诱导多能干细胞源性肠细胞样细胞的建立及其在药代动力学研究中的应用
Shinpei Yoshida,Takayuki Honjo,Keita Iino et al.
Shinpei Yoshida et al.
We aimed to establish an in vitro differentiation procedure to generate matured small intestinal cells mimicking human small intestine from human-induced pluripotent stem cells (iPSCs). We previously reported the efficient generation of CDX...
Cell-to-Cell Adhesion and Neurogenesis in Human Cortical Development: A Study Comparing 2D Monolayers with 3D Organoid Cultures [0.03%]
人皮层发育中细胞间粘附与神经发生：二维单层培养与三维类器官培养的比较研究
Soraya Scuderi,Giovanna G Altobelli,Vincenzo Cimini et al.
Soraya Scuderi et al.
Organoids (ORGs) are increasingly used as models of cerebral cortical development. Here, we compared transcriptome and cellular phenotypes between telencephalic ORGs and monolayers (MONs) generated in parallel from three biologically distin...
Gene Therapy of Dominant CRX-Leber Congenital Amaurosis using Patient Stem Cell-Derived Retinal Organoids [0.03%]
利用患者干细胞系视网膜器官样结构进行显性CRX-Leber先天性黑蒙基因治疗
Kamil Kruczek,Zepeng Qu,James Gentry et al.
Kamil Kruczek et al.
Mutations in the photoreceptor transcription factor gene cone-rod homeobox (CRX) lead to distinct retinopathy phenotypes, including early-onset vision impairment in dominant Leber congenital amaurosis (LCA). Using induced pluripotent stem c...
Depletion of Trp53 and Cdkn2a Does Not Promote Self-Renewal in the Mammary Gland but Amplifies Proliferation Induced by TNF-α [0.03%]
Trp53和Cdkn2a的丢失不会促进乳腺干细胞的自我更新，但可放大TNF-α所诱导的增殖反应
Linda J van Weele,Ferenc A Scheeren,Shang Cai et al.
Linda J van Weele et al.
The mammary epithelium undergoes several rounds of extensive proliferation during the female reproductive cycle. Its expansion is a tightly regulated process, fueled by the mammary stem cells and these cells' unique property of self-renewal...
Gastruloid Development Competence Discriminates Different States of Pluripotency [0.03%]
胃原体发育能力鉴别多能性不同状态
Federica Cermola,Cristina D&#x;Aniello,Rosarita Tatè et al.
Federica Cermola et al.
Floating spheroidal aggregates of mouse embryonic stem cells can develop into polarized/elongated organoids, namely gastruloids. We set up a high-performing assay to measure gastruloid formation efficiency (GFE), and found that GFE decrease...
Murine Myeloid Progenitors Attenuate Immune Dysfunction Induced by Hemorrhagic Shock [0.03%]
鼠源髓样前体细胞可减轻出血性休克引起的免疫功能障碍
Joshua T Cohen,Michael Danise,Jason T Machan et al.
Joshua T Cohen et al.
Hemorrhagic shock induces an aberrant immune response characterized by simultaneous induction of a proinflammatory state and impaired host defenses. The objective of this study was to evaluate the impact of conditionally immortalized neutro...
Microglia-Secreted Factors Enhance Dopaminergic Differentiation of Tissue- and iPSC-Derived Human Neural Stem Cells [0.03%]
小胶质细胞分泌因子可促进组织和iPSC来源的人类神经干细胞向多巴胺能神经元分化
Sissel Ida Schmidt,Helle Bogetofte,Louise Ritter et al.
Sissel Ida Schmidt et al.
Microglia have recently been established as key regulators of brain development. However, their role in neuronal subtype specification remains largely unknown. Using three different co-culture setups, we show that microglia-secreted factors...