Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Enables Modeling of Human Hypertrophic Cardiomyopathy [0.03%]
人多能干细胞分化心肌细胞的成熟使人类肥厚型心肌病模型成为可能
Walter E Knight,Yingqiong Cao,Ying-Hsi Lin et al.
Walter E Knight et al.
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a powerful platform for biomedical research. However, they are immature, which is a barrier to modeling adult-onset cardiovascular disease. Here, we sought to develo...
DNMTs Play an Important Role in Maintaining the Pluripotency of Leukemia Inhibitory Factor-Dependent Embryonic Stem Cells [0.03%]
DNA甲基化转移酶在维持LIF依赖的胚胎干细胞多能性中起重要作用
Baojiang Wu,Yunxia Li,Bojiang Li et al.
Baojiang Wu et al.
Naive pluripotency can be maintained in medium with two inhibitors plus leukemia inhibitory factor (2i/LIF) supplementation, which primarily affects canonical WNT, FGF/ERK, and JAK/STAT3 signaling. However, whether one of these three supple...
Kelsey R Babcock,John S Page,Justin R Fallon et al.
Kelsey R Babcock et al.
Cognitive deficits associated with Alzheimer's disease (AD) severely impact daily life for the millions of affected individuals. Progressive memory impairment in AD patients is associated with degeneration of the hippocampus. The dentate gy...
Age-Related Changes in the Inflammatory Status of Human Mesenchymal Stem Cells: Implications for Cell Therapy [0.03%]
人细胞治疗相关炎症状态的人 mesenchymal干细胞年龄相关变化：细胞治疗的含义
Ying Zhang,Maanasa Ravikumar,Ling Ling et al.
Ying Zhang et al.
Human mesenchymal stem/stromal cell (hMSC)-based cell therapies are promising for treating a variety of diseases. The unique immunomodulatory properties of hMSCs have extended their therapeutic potential beyond tissue regeneration. However,...
Unique Patterns of H3K4me3 and H3K27me3 in 2-Cell-like Embryonic Stem Cells [0.03%]
二细胞样胚胎干细胞中H3K4me3和H3K27me3的 unique 模式
Yanping Zhang,Yixin Huang,Yu Dong et al.
Yanping Zhang et al.
A small subgroup of embryonic stem cells (ESCs) exhibit molecular features similar to those of two-cell embryos (2C). However, it remains elusive whether 2C-like cells and 2C embryos share similar epigenetic features. Here, we map the genom...
Differentiation of Hypertrophic Chondrocytes from Human iPSCs for the In Vitro Modeling of Chondrodysplasias [0.03%]
人多能诱导型干细胞分化成 hypertrophic软骨细胞用于遗传性软骨发育不良的体外建模研究
Yann Pretemer,Shunsuke Kawai,Sanae Nagata et al.
Yann Pretemer et al.
Chondrodysplasias are hereditary diseases caused by mutations in the components of growth cartilage. Although the unfolded protein response (UPR) has been identified as a key disease mechanism in mouse models, no suitable in vitro system ha...
Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection [0.03%]
人类的共同遗传变异影响对SARS-CoV-2感染的易感性
Kristina Dobrindt,Daisy A Hoagland,Carina Seah et al.
Kristina Dobrindt et al.
The host response to SARS-CoV-2, the etiologic agent of the COVID-19 pandemic, demonstrates significant interindividual variability. In addition to showing more disease in males, the elderly, and individuals with underlying comorbidities, S...
Neurotropic Effects of SARS-CoV-2 Modeled by the Human Brain Organoids [0.03%]
新型冠状病毒(SARS-CoV-2)感染人脑类器官模型的神经毒性作用研究
Anand Ramani,Abida-Islam Pranty,Jay Gopalakrishnan
Anand Ramani
COVID-19, caused by SARS-CoV-2, is a socioeconomic burden, which exhibits respiratory illness along with unexpected neurological complications. Concerns have been raised about whether the observed neurological symptoms are due to direct eff...
Revealing Tissue-Specific SARS-CoV-2 Infection and Host Responses using Human Stem Cell-Derived Lung and Cerebral Organoids [0.03%]
利用人类干细胞系的肺和脑类器官揭示SARS-CoV-2感染及宿主免疫反应
Shashi Kant Tiwari,Shaobo Wang,Davey Smith et al.
Shashi Kant Tiwari et al.
COVID-19 is a transmissible respiratory disease caused by a novel coronavirus, SARS-CoV-2, and has become a global health emergency. There is an urgent need for robust and practical in vitro model systems to investigate viral pathogenesis. ...
Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus [0.03%]
人肠道类器官再现肠病毒和冠状病毒所致的肠道感染
Xiaoyu Zhao,Cun Li,Xiaojuan Liu et al.
Xiaoyu Zhao et al.
Enteroviruses, such as EV-A71 and CVA16, mainly infect the human gastrointestinal tract. Human coronaviruses, including SARS-CoV and SARS-CoV-2, have been variably associated with gastrointestinal symptoms. We aimed to optimize the human in...