Joachim Luginbühl,Tsukasa Kouno,Rei Nakano et al.
Joachim Luginbühl et al.
Cellular reprogramming is driven by a defined set of transcription factors; however, the regulatory logic that underlies cell-type specification and diversification remains elusive. Single-cell RNA-seq provides unprecedented coverage to mea...
Generation and Differentiation of Adult Tissue-Derived Human Thyroid Organoids [0.03%]
由成人组织衍生的甲状腺器官体的生成和分化
Vivian M L Ogundipe,Andries H Groen,Nynke Hosper et al.
Vivian M L Ogundipe et al.
Total thyroidectomy as part of thyroid cancer treatment results in hypothyroidism requiring lifelong daily thyroid hormone replacement. Unbalanced hormone levels result in persistent complaints such as fatigue, constipation, and weight incr...
Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy [0.03%]
人胚胎干细胞中ISL1阳性心肌细胞的筛选及用于心梗治疗的潜能评估研究进展
Zaniar Ghazizadeh,Faranak Fattahi,Mehdi Mirzaei et al.
Zaniar Ghazizadeh et al.
Published Erratum
Stem cell reports. 2021 Mar 9;16(3):666-668. DOI:10.1016/j.stemcr.2021.01.012 2021
The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19 [0.03%]
类器官平台：作为抗击COVID-19工具的机遇与挑战
Maarten H Geurts,Jelte van der Vaart,Joep Beumer et al.
Maarten H Geurts et al.
Many pathogenic viruses that affect man display species specificity, limiting the use of animal models. Studying viral biology and identifying potential treatments therefore benefits from the development of in vitro cell systems that closel...
Broad-Spectrum Anti-coronavirus Vaccines and Therapeutics to Combat the Current COVID-19 Pandemic and Future Coronavirus Disease Outbreaks [0.03%]
对抗当前COVID-19大流行和未来冠状病毒疾病暴发的广谱抗冠状病毒疫苗和治疗药物
Miao Cao,Xiaojie Su,Shibo Jiang
Miao Cao
While the COVID-19 pandemic caused by SARS-CoV-2 is continuing, it may become worse in the coming winter months with a high potential for the emergence and spread of escape variants of SARS-CoV-2. SARS-related CoVs (SARSr-CoVs) from bats ma...
Modulation of APLNR Signaling Is Required during the Development and Maintenance of the Hematopoietic System [0.03%]
APLNR信号转导在造血系统发育和维持过程中是必需的
Melany Jackson,Antonella Fidanza,A Helen Taylor et al.
Melany Jackson et al.
Apelin receptor (APLNR/AGTRLl1/APJ) marks a transient cell population during the differentiation of hematopoietic stem and progenitor cells (HSPCs) from pluripotent stem cells, but its function during the production and maintenance of hemat...
Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes [0.03%]
双相情感障碍患者来源的星形胶质细胞中神经元支持和炎症反应改变
Krishna C Vadodaria,Ana P D Mendes,Arianna Mei et al.
Krishna C Vadodaria et al.
Bipolar disorder (BD) is characterized by cyclical mood shifts. Studies indicate that BD patients have a peripheral pro-inflammatory state and alterations in glial populations in the brain. We utilized an in vitro model to study inflammatio...
Janet Rossant,Patrick P L Tam
Janet Rossant
Stem cell-based embryo models open an unprecedented avenue for modeling embryogenesis, cell lineage differentiation, tissue morphogenesis, and organogenesis in mammalian development. Experimentation on these embryo models can lead to a bett...
SARS-CoV-2 Infects Human Pluripotent Stem Cell-Derived Cardiomyocytes, Impairing Electrical and Mechanical Function [0.03%]
SARS-CoV-2感染人类多能干细胞来源的心肌细胞，并影响其电学和力学功能
Silvia Marchiano,Tien-Ying Hsiang,Akshita Khanna et al.
Silvia Marchiano et al.
COVID-19 patients often develop severe cardiovascular complications, but it remains unclear if these are caused directly by viral infection or are secondary to a systemic response. Here, we examine the cardiac tropism of SARS-CoV-2 in human...
Spermatogonial Stem Cell Numbers Are Reduced by Transient Inhibition of GDNF Signaling but Restored by Self-Renewing Replication when Signaling Resumes [0.03%]
GDNF信号转导暂时受到抑制时 spermatogonial干细胞数量减少但当信号转导恢复后通过自我更新复制得到补偿
Nicole Parker,Andrew Laychur,Meena Sukwani et al.
Nicole Parker et al.
One cause of human male infertility is a scarcity of spermatogonial stem cells (SSCs) in testes with Sertoli cells that neither produce adequate amounts of GDNF nor form the Sertoli-Sertoli junctions that form the blood-testis barrier (BTB)...