3D Image Analysis of the Complete Ventricular-Subventricular Zone Stem Cell Niche Reveals Significant Vasculature Changes and Progenitor Deficits in Males Versus Females with Aging [0.03%]
三维图像分析完整室亚室区干细胞生态位揭示随着衰老男性与女性血管变化及前体细胞缺陷明显不同
Xiuli Zhao,Yue Wang,Eric Wait et al.
Xiuli Zhao et al.
With age, neural stem cell (NSC) function in the adult ventricular-subventricular zone (V-SVZ) declines, reducing memory and cognitive function in males; however, the impact on females is not well understood. To obtain a global view of how ...
Shane Browne,Elisabeth L Gill,Paula Schultheiss et al.
Shane Browne et al.
Microphysiological systems (MPSs) (i.e., tissue or organ chips) exploit microfluidics and 3D cell culture to mimic tissue and organ-level physiology. The advent of human induced pluripotent stem cell (hiPSC) technology has accelerated the u...
Efficient conversion of human induced pluripotent stem cells into microglia by defined transcription factors [0.03%]
利用转录因子将人类诱导多能干细胞有效转化为小胶质细胞
Shih-Wei Chen,Yu-Sheng Hung,Jong-Ling Fuh et al.
Shih-Wei Chen et al.
Microglia, the immune cells of the central nervous system, play critical roles in brain physiology and pathology. We report a novel approach that produces, within 10 days, the differentiation of human induced pluripotent stem cells (hiPSCs)...
Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species [0.03%]
多种哺乳动物体细胞非病毒诱导的无转基因 iPSCs
Sho Yoshimatsu,Mayutaka Nakajima,Aozora Iguchi et al.
Sho Yoshimatsu et al.
Induced pluripotent stem cells (iPSCs) are capable of providing an unlimited source of cells from all three germ layers and germ cells. The derivation and usage of iPSCs from various animal models may facilitate stem cell-based therapy, gen...
Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex [0.03%]
分子分析揭示ESCO2在发育小鼠皮层中间前体细胞维持中的作用
Pauline Antonie Ulmke,M Sadman Sakib,Peter Ditte et al.
Pauline Antonie Ulmke et al.
Intermediate progenitor cells (IPCs) are neocortical neuronal precursors. Although IPCs play crucial roles in corticogenesis, their molecular features remain largely unknown. In this study, we aimed to characterize the molecular profile of ...
Adhesion GPCR Latrophilin-2 Specifies Cardiac Lineage Commitment through CDK5, Src, and P38MAPK [0.03%]
黏附G蛋白偶联受体Latrophilin-2通过CDK5、Src和P38MAPK规定心脏谱系决定
Choon-Soo Lee,Hyun-Jai Cho,Jin-Woo Lee et al.
Choon-Soo Lee et al.
Identifying lineage-specific markers is pivotal for understanding developmental processes and developing cell therapies. Here, we investigated the functioning of a cardiomyogenic cell-surface marker, latrophilin-2 (LPHN2), an adhesion G-pro...
Ani Grigoryan,Johannes Pospiech,Stephen Krämer et al.
Ani Grigoryan et al.
During X chromosome inactivation (XCI), the inactive X chromosome (Xi) is recruited to the nuclear lamina at the nuclear periphery. Beside X chromosome reactivation resulting in a highly penetrant aging-like hematopoietic malignancy, little...
Characterization of hiPSC-Derived Muscle Progenitors Reveals Distinctive Markers for Myogenic Cell Purification Toward Cell Therapy [0.03%]
人诱导多能干细胞来源的肌细胞系标记物鉴定为细胞治疗肌肉干细胞纯化提供理论依据及新型策略
Minas Nalbandian,Mingming Zhao,Mitsuru Sasaki-Honda et al.
Minas Nalbandian et al.
The transplantation of muscle progenitor cells (MuPCs) differentiated from human induced pluripotent stem cells (hiPSCs) is a promising approach for treating skeletal muscle diseases such as Duchenne muscular dystrophy (DMD). However, prope...
Autophagy-Mediated Activation of Mucosal-Associated Invariant T Cells Driven by Mesenchymal Stem Cell-Derived IL-15 [0.03%]
间充质干细胞衍生的IL-15介导的黏膜相关不变T细胞活化及其自噬机制研究
Guiwen Ye,Peng Wang,Zhongyu Xie et al.
Guiwen Ye et al.
Mucosal-associated invariant T (MAIT) cells are innate-like unconventional T cells that are abundant in humans and have attracted increasing attention in recent years. Mesenchymal stem cells (MSCs) are crucial regulators of immune cells. Ho...
Low Immunogenicity and Immunosuppressive Properties of Human ESC- and iPSC-Derived Retinas [0.03%]
人胚胎干细胞和诱导 pluripotent stem细胞衍生视网膜低免疫原性及免疫抑制特性
Suguru Yamasaki,Sunao Sugita,Matsuri Horiuchi et al.
Suguru Yamasaki et al.
ESC- and iPSC-derived retinal transplantation is a promising therapeutic approach for disease with end-stage retinal degeneration, such as retinitis pigmentosa and age-related macular degeneration. We previously showed medium- to long-term ...