Machine learning-assisted high-content analysis of pluripotent stem cell-derived embryos in vitro [0.03%]
机器学习辅助的多能干细胞衍生胚胎体外高内涵分析
Jianying Guo,Peizhe Wang,Berna Sozen et al.
Jianying Guo et al.
Stem cell-based embryo models by cultured pluripotent and extra-embryonic lineage stem cells are novel platforms to model early postimplantation development. We showed that induced pluripotent stem cells (iPSCs) could form ITS (iPSCs and tr...
Reprogramming epiblast stem cells into pre-implantation blastocyst cell-like cells [0.03%]
诱导胚外内细胞团干细胞成为植入前胚胎的囊胚期细胞类似物
Kiichiro Tomoda,Haiming Hu,Yoshiki Sahara et al.
Kiichiro Tomoda et al.
Recently, a new wave of synthetic embryo systems (SESs) has been established from cultured cells for efficient and ethical embryonic development research. We recently reported our epiblast stem cell (EPISC) reprogramming SES that generates ...
Engineering spatial-organized cardiac organoids for developmental toxicity testing [0.03%]
工程化空间构型心脏器官体用于发育毒理学检测
Plansky Hoang,Andrew Kowalczewski,Shiyang Sun et al.
Plansky Hoang et al.
Emerging technologies in stem cell engineering have produced sophisticated organoid platforms by controlling stem cell fate via biomaterial instructive cues. By micropatterning and differentiating human induced pluripotent stem cells (hiPSC...
Mitochondrial state determines functionally divergent stem cell population in planaria [0.03%]
线粒体状态决定扁形动物干细胞分化方向
Mohamed Mohamed Haroon,Vairavan Lakshmanan,Souradeep R Sarkar et al.
Mohamed Mohamed Haroon et al.
Mitochondrial state changes were shown to be critical for stem cell function. However, variation in the mitochondrial content in stem cells and the implication, if any, on differentiation is poorly understood. Here, using cellular and molec...
Balancing serendipity and reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders [0.03%]
机遇与可重复性的平衡：多能干细胞作为智力和发育障碍的实验系统
Nickesha C Anderson,Pin-Fang Chen,Kesavan Meganathan et al.
Nickesha C Anderson et al.
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and their differentiation into neural lineages is a revolutionary experimental system for studying neurological disorders, including intellectual and developmental d...
Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response [0.03%]
人多能干细胞来源的肠类器官模拟SARS-CoV-2感染并揭示其共同上皮炎症反应
Aditya Mithal,Adam J Hume,Jonathan Lindstrom-Vautrin et al.
Aditya Mithal et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leading to coronavirus disease 2019 (COVID-19) usually results in respiratory disease, but extrapulmonary manifestations are of major clinical interest. Intestinal sympt...
Stefania Carobbio,Anne-Claire Guenantin,Myriam Bahri et al.
Stefania Carobbio et al.
Published Erratum
Stem cell reports. 2021 Apr 13;16(4):1010. DOI:10.1016/j.stemcr.2021.03.009 2021
Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System [0.03%]
利用快速且可扩展的的人类运动神经元分化系统建模低氧诱导的神经病变
Laura I Hudish,Andrew Bubak,Taylor M Triolo et al.
Laura I Hudish et al.
Published Erratum
Stem cell reports. 2021 Apr 13;16(4):1009. DOI:10.1016/j.stemcr.2021.03.006 2021
Long noncoding RNA ADINR regulates adipogenesis by transcriptionally activating C/EBPα [0.03%]
长非编码RNA ADINR通过转录激活C/EBPα调控脂肪生成
Tengfei Xiao,Lihui Liu,Hongling Li et al.
Tengfei Xiao et al.
Published Erratum
Stem cell reports. 2021 Apr 13;16(4):1006-1008. DOI:10.1016/j.stemcr.2021.03.024 2021
Carlos W Gantner,Cameron P J Hunt,Jonathan C Niclis et al.
Carlos W Gantner et al.
Despite heterogeneity across the six layers of the mammalian cortex, all excitatory neurons are generated from a single founder population of neuroepithelial stem cells. However, how these progenitors alter their layer competence over time ...