All models are wrong, but some are useful: Establishing standards for stem cell-based embryo models [0.03%]
皆为谬论，但有的有用——基于干细胞的胚胎模型的标准建立
Eszter Posfai,Fredrik Lanner,Carla Mulas et al.
Eszter Posfai et al.
Detailed studies of the embryo allow an increasingly mechanistic understanding of development, which has proved of profound relevance to human disease. The last decade has seen in vitro cultured stem cell-based models of embryo development ...
Ananya Gupta,Matthias P Lutolf,Alex J Hughes et al.
Ananya Gupta et al.
Stem cell-based in vitro models of embryonic development have been established over the last decade. Such model systems recapitulate aspects of gametogenesis, early embryonic development, or organogenesis. They enable experimental approache...
Tomonori Nakamura,Kohei Fujiwara,Mitinori Saitou et al.
Tomonori Nakamura et al.
Human development has been studied for over a century, but the molecular mechanisms underlying human embryogenesis remain largely unknown due to technical difficulties and ethical issues. Accordingly, mice have been used as a model for mamm...
Conserved features of non-primate bilaminar disc embryos and the germline [0.03%]
非灵长类bilaminar胚盘胚胎和生殖系的保守特征
Ramiro Alberio,Toshihiro Kobayashi,M Azim Surani
Ramiro Alberio
Post-implantation embryo development commences with a bilaminar disc in most mammals, including humans. Whereas access to early human embryos is limited and subject to greater ethical scrutiny, studies on non-primate embryos developing as b...
Lizhong Liu,Aryeh Warmflash
Lizhong Liu
Mammalian embryonic development is a complex process driven by self-organization. Understanding how a fertilized egg develops into an embryo composed of more than 200 cell types in precise spatial patterns remains one of the fundamental cha...
Christine Ho,Leonardo Morsut
Christine Ho
Recently, developmental systems are investigated with increasing technological power. Still, open questions remain, especially concerning self-organization capacity and its control. Here, we present three areas where synthetic biology tools...
From embryos to embryoids: How external signals and self-organization drive embryonic development [0.03%]
从胚胎到胚体：外部信号和自我组织如何驱动胚胎发育
J Serrano Morales,Jelena Raspopovic,Luciano Marcon
J Serrano Morales
Embryonic development has been traditionally seen as an inductive process directed by exogenous maternal inputs and extra-embryonic signals. Increasing evidence, however, is showing that, in addition to exogenous signals, the development of...
Biomedical and societal impacts of in vitro embryo models of mammalian development [0.03%]
哺乳动物发育的体外胚胎模型的生物医学和社会影响
Naomi Moris,Cantas Alev,Martin Pera et al.
Naomi Moris et al.
In recent years, a diverse array of in vitro cell-derived models of mammalian development have been described that hold immense potential for exploring fundamental questions in developmental biology, particularly in the case of the human em...
Nicolas Rivron,Jianping Fu
Nicolas Rivron
Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures [0.03%]
休眠培养中造血干细胞保留功能潜能和分子身份
Caroline A Oedekoven,Miriam Belmonte,Daniel Bode et al.
Caroline A Oedekoven et al.
Advances in the isolation and gene expression profiling of single hematopoietic stem cells (HSCs) have permitted in-depth resolution of their molecular program. However, long-term HSCs can only be isolated to near purity from adult mouse bo...