Modeling diabetic alpha cell dysfunction using stem cell-derived alpha cells [0.03%]
利用干细胞分化得到的α细胞模拟糖尿病性α细胞功能异常
Swikriti Shrestha,Lauren T Jennings,Kyle Knofczynski et al.
Swikriti Shrestha et al.
Dysfunction of pancreatic alpha cells contributes to the pathophysiology of diabetes. Features of diabetic alpha cell dysfunction include glucagon hypersecretion, defects in proglucagon processing, and altered transcriptomic profile. The la...
Leveraging CRISPR activation for rapid assessment of gene editing products in human pluripotent stem cells [0.03%]
利用CRISPR激活技术快速评估人多能干细胞基因编辑产品
Youjun Wu,Aaron Zhong,Alessandro Evangelisti et al.
Youjun Wu et al.
Verification of genome editing in human pluripotent stem cells (hPSCs), particularly at silent loci, is desirable but challenging, as it often requires complex and time-intensive differentiation to induce their expression. Here, we establis...
Identifying enabling strategies for effective public dialogue in human embryo research [0.03%]
识别有效的人类胚胎研究公共对话的促成策略
Matilda Beckett,Sarah Franklin,Peter J Rugg-Gunn
Matilda Beckett
Public dialogue is crucial for understanding societal views on human embryo research, and the complexity and sensitivity of this topic require special considerations of how such dialogues are facilitated. Here, we identify enablers of effec...
Hypoxia and loss of GCM1 expression prevent differentiation and contact inhibition in human trophoblast stem cells [0.03%]
低氧和GCM1表达缺失阻碍人绒毛膜干细胞分化和接触抑制作用
Jessica K Cinkornpumin,Sin Young Kwon,Anna-Maria Prandstetter et al.
Jessica K Cinkornpumin et al.
During the first stages of embryonic development, the placenta develops under very low oxygen tension (∼1%-2% O2), so we sought to determine the regulatory role of oxygen in human trophoblast stem cells (hTSCs). We find that low oxygen pro...
MIXL1 activation in endoderm differentiation of human induced pluripotent stem cells [0.03%]
人诱导多能干细胞内胚层分化过程中MIXL1的激活作用
Pierre Osteil,Sarah Withey,Nicole Santucci et al.
Pierre Osteil et al.
Human induced pluripotent stem cells (hiPSCs) possess the ability to differentiate into a multitude of cell and tissue types but display heterogeneous propensity of differentiation into specific lineage. Characterization of the transcriptom...
What does "appropriate scientific justification" mean for the review of human pluripotent stem cell, embryo, and related research? [0.03%]
“适当的科学理由”对人多能干细胞、胚胎和相关研究的监管审查意味着什么？
Erica C Jonlin,Misao Fujita,Rosario Isasi et al.
Erica C Jonlin et al.
This article complements the 2021 International Society for Stem Cell Research (ISSCR) Guidelines for Stem Cell Research and Clinical Translation by explaining what "adequate and appropriate scientific justification" means for human pluripo...
Exercise promotes the functional integration of human stem cell-derived neural grafts in a rodent model of Parkinson's disease [0.03%]
运动促进人干细胞源神经移植在帕金森病鼠模型中的功能整合
Niamh Moriarty,Tyra D Fraser,Cameron P J Hunt et al.
Niamh Moriarty et al.
Human pluripotent stem cell (hPSC)-derived dopamine neurons can functionally integrate and reverse motor symptoms in Parkinson's disease models, motivating current clinical trials. However, dopamine neuron proportions remain low and their p...
Language and labels from the lab: Definitions in the stem cell-based embryo model debate [0.03%]
实验室里的语言和标签：“基于干细胞的胚胎模型”争论中的定义问题
Hafez Ismaili M&#x;hamdi
Hafez Ismaili M&#x;hamdi
This article examines the definitional challenges surrounding stem cell-based embryo models. Terms like "synthetic embryos" misrepresent their nature and influence public discourse. I argue for a multidisciplinary approach, integrating scie...
CD37 regulates the self-renewal of leukemic stem cells via integrin-mediated signaling in acute myeloid leukemia [0.03%]
CD37通过整合素介导的信号转导调节急性髓系白血病白血病干细胞的自我更新
Jinyuan Lu,Lixin Lv,Xiaoxue Tian et al.
Jinyuan Lu et al.
Leukemic stem cells (LSCs) are a small subset of leukemia cells that drive leukemia initiation and maintenance. Herein, we report that CD37, a member of transmembrane 4 superfamily (TM4SF), regulates the survival of acute myeloid leukemia (...
Perinuclear mitochondrial clustering for mesenchymal-to-epithelial transition in pluripotency induction [0.03%]
富集于核周的线粒体动态聚集簇促进多能性诱导中的间质细胞向上皮细胞转化 MET过程中的核周线粒体聚群现象促进了多能性的诱导发生
Ge Xiang,Zihuang Liu,Zebin Yuan et al.
Ge Xiang et al.
Remodeled mitochondria are characteristic of pluripotent stem cells. However, a role for mitochondrial movement and distribution in pluripotency remains unknown. Here, we show that mitochondrial retrograde transport-mediated perinuclear clu...