MECP2 mutations rewire human ESC fate and bias cortical lineage commitment [0.03%]
MECP2突变重塑人胚胎干细胞命运并偏向皮层谱系分化方向
Marion Guillon,Margaux Brin,Elodie Gabet et al.
Marion Guillon et al.
Rett syndrome arises from loss-of-function mutations in the X-linked chromatin regulator MECP2, yet the earliest molecular derailments in development are poorly defined. Using isogenic human embryonic stem cell (hESC) models carrying three ...
An optimized protocol for efficient derivation of pancreatic islets from multiple human pluripotent stem cell lines [0.03%]
一种优化的高效制备人多能干细胞系胰岛细胞的分化方案
Siqin Wu,Shivam Chandel,Galyna Bryzgalova et al.
Siqin Wu et al.
The success of cell therapy for type 1 diabetes (T1D) depends on reliable differentiation of stem cells into functional pancreatic islets. Current protocols produce stem cell-derived islets (SC-islets) that contain non-endocrine cells and s...
Cytoarchitecture of neurogenic niche and neuroblast clusters in the postnatal microminipig brain [0.03%]
微小型猪产后脑神经发生生态位和神经干细胞群的细胞结构
Daijiro Kojima,Masato Sawada,Taisei Ishimaru et al.
Daijiro Kojima et al.
The ventricular-subventricular zone (V-SVZ) is the largest neurogenic niche in the postnatal mammalian brain, but its organization and migratory dynamics remain poorly understood in gyrencephalic species. Here, we provide ultrastructural an...
Organoid phenotypic screening identified glycyrrhizin that confers protection against tumor necrosis factor-induced cell death [0.03%]
类器官表型筛选鉴定出甘草甜素可使肿瘤坏死因子诱导的细胞死亡得到保护
Yu Takahashi,Zhongwei Zhang,Izumi Tanaka et al.
Yu Takahashi et al.
Human organoids are considered physiological models that reflect human physiology; however, their applications in drug screening studies are limited. To develop a fundamental treatment for recurrent Crohn's disease (CD), in which tumor necr...
Pluripotent stem cell lines available for use in clinical applications: A comprehensive overview [0.03%]
可供临床应用的多能干细胞系概览
Melissa K Carpenter,Tenneille E Ludwig
Melissa K Carpenter
Published Erratum
Stem cell reports. 2026 Apr 14:102897. DOI:10.1016/j.stemcr.2026.102897 2026
Cranial placode differentiation defect in individuals born without a nose [0.03%]
鼻部胎胎节分化缺陷导致先天性无鼻小柱综合征
Vanitha Venkoba Rao,Xinran Ji,Jasmine Yi Ying Heng et al.
Vanitha Venkoba Rao et al.
Bosma arhinia microphthalmia syndrome (BAMS) is a rare congenital disorder characterized by the absence of a nose, along with eye and reproductive anomalies. BAMS is caused by heterozygous missense variants in SMCHD1, an epigenetic regulato...
Dietary restriction mitigates 5-fluorouracil-induced thrombocytopenia in aged mice via mitochondrial potentiation in hematopoietic stem cells and megakaryocyte progenitors [0.03%]
饮食限制通过造血干细胞和巨核细胞祖细胞的线粒体活化减轻老年小鼠氟尿嘧啶诱导的血小板减少症
Xingxing Qiu,Duozhuang Tang,Jiahao Lin et al.
Xingxing Qiu et al.
With population aging, chemotherapy-induced thrombocytopenia (CIT) is a severe complication in elderly cancer patients, yet effective preventive and therapeutic strategies remain limited. Here, we demonstrate that dietary restriction (DR) s...
Discovery of kidney disease targets using multimodal human podocyte injury models [0.03%]
多模态人类足细胞损伤模型发现肾脏疾病靶点
Amanda D Barreto,Bowen Jiang,Morgan A Burt et al.
Amanda D Barreto et al.
Podocyte injury is a hallmark of chronic kidney disease (CKD) and organ failure, but whether different injury signals perturb unified or distinct molecular targets remains unclear. Using human induced pluripotent stem cell (hiPSC)-derived p...
A semi-automated MEA spike sorting method for high-throughput assessment of cultured neurons [0.03%]
一种高通量评估培养神经元的半自动MEA尖峰分类方法
Xiaoxuan Ren,Carissa L Sirois,Raymond Doudlah et al.
Xiaoxuan Ren et al.
Neurons derived from human pluripotent stem cells (hPSCs) are valuable models for studying brain development and developing therapies for brain disorders. Evaluating hPSC-derived neurons requires assessing their electrical activity, which c...
Rheostats, not switches: Nuclear receptor dosage tunes somatic-to-iPSC reprogramming [0.03%]
剂量效应而非开关效应：核受体剂量调控体细胞向诱导多能干细胞重编程过程
Constantinos Chronis
Constantinos Chronis
Nuclear receptors are modular transcription factors regulated by ligands, chromatin context, and expression level. Wang et al. 2026, in this issue of Stem Cell Reports show that Rora controls OKS-mediated reprogramming in a dose-dependent m...