Sina Mohammadi,Carolina Morell-Perez,Charles W Wright et al.
Sina Mohammadi et al.
Donor-to-donor variability in primary human organoid cultures has not been well characterized. As these cultures contain multiple cell types, there is greater concern that variability could lead to increased noise. In this work we investiga...
APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation [0.03%]
APOE4载小胶质细胞过量向神经元供应胆固醇以促进神经突触腔膜微结构域扩张及Aβ生成
Se-In Lee,Woojin Jeong,Heejin Lim et al.
Se-In Lee et al.
The ε4 allele of APOE-encoding apolipoprotein (ApoE) is one of the strongest genetic risk factors for Alzheimer's disease (AD). One of the overarching questions is whether and how this astrocyte-enriched risk factor initiates AD-associated...
De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells [0.03%]
从头DNA甲基转移酶DNMT3A和DNMT3B是多能干细胞剂量补偿侵蚀过程中XIST基因沉默所必需的
Atsushi Fukuda,Dane Z Hazelbaker,Nami Motosugi et al.
Atsushi Fukuda et al.
Human pluripotent stem cells (hPSCs) have proven to be valuable tools for both drug discovery and the development of cell-based therapies. However, the long non-coding RNA XIST, which is essential for the establishment and maintenance of X ...
Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2 [0.03%]
新冠病毒感染心肌细胞后，心肌细胞通过分泌CCL2招募单核细胞
Liuliu Yang,Benjamin E Nilsson-Payant,Yuling Han et al.
Liuliu Yang et al.
Heart injury has been reported in up to 20% of COVID-19 patients, yet the cause of myocardial histopathology remains unknown. Here, using an established in vivo hamster model, we demonstrate that SARS-CoV-2 can be detected in cardiomyocytes...
Progesterone receptor-DNA methylation crosstalk regulates depletion of uterine leiomyoma stem cells: A potential therapeutic target [0.03%]
孕酮受体-DNA甲基化交叉调节作用可清除子宫肌瘤干细胞：潜在的治疗靶点
Shimeng Liu,Ping Yin,Jingting Xu et al.
Shimeng Liu et al.
Uterine leiomyoma (LM) is the most common tumor in women. Via its receptor (PGR) expressed in differentiated LM cells, progesterone stimulates paracrine signaling that induces proliferation of PGR-deficient LM stem cells (LSCs). Antiprogest...
Patient-specific iPSC-derived endothelial cells reveal aberrant p38 MAPK signaling in atypical hemolytic uremic syndrome [0.03%]
针对患者的iPSC衍生的内皮细胞揭示了非典型溶血性尿毒症综合症中的异常p38 MAPK信号转导
Danni Zhou,Ying Tan,Xiaoling Liu et al.
Danni Zhou et al.
Atypical hemolytic uremic syndrome (aHUS) is a rare disease associated with high morbidity and mortality. Existing evidence suggests that the central pathogenesis to aHUS might be endothelial cell damage. Nevertheless, the role of endotheli...
Benjamin A Yang,Jesus Castor-Macias,Paula Fraczek et al.
Benjamin A Yang et al.
The health and homeostasis of skeletal muscle are preserved by a population of tissue-resident muscle stem cells (MuSCs) that maintain a state of mitotic and metabolic quiescence in adult tissues. The capacity of MuSCs to preserve the quies...
Rethink the patentability of human embryonic stem cell research findings: Relaxation based on benefit weighing [0.03%]
重新思考人胚胎干细胞研究结果的专利性：基于利益权衡的放松策略
Jiajv Chen,Wei Li
Jiajv Chen
Attitudes toward the patentability of the human embryonic stem cell (hESC) research findings are undergoing dynamic adjustment based on benefit weighing. In the early stage, ethical concerns prevailed: both the United States and China place...
EBiSC best practice: How to ensure optimal generation, qualification, and distribution of iPSC lines [0.03%]
EBiSC最佳实践：如何确保诱导多能干细胞系的最佳生成、鉴定和分发
Rachel Steeg,Sabine C Mueller,Nancy Mah et al.
Rachel Steeg et al.
Disease-relevant human induced pluripotent stem cells (iPSCs) are generated worldwide for research purposes; however, without robust and practical ethical, legal, and quality standards, there is a high risk that their true potential will no...
Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification [0.03%]
TROY/TNFRSF19标记表皮细胞以调控角质形成细胞的更新及角化过程
Kai Kretzschmar,Kim E Boonekamp,Margit Bleijs et al.
Kai Kretzschmar et al.
The skin epidermis is a highly compartmentalized tissue consisting of a cornifying epithelium called the interfollicular epidermis (IFE) and associated hair follicles (HFs). Several stem cell populations have been described that mark specif...