Tetraspanin CD82 regulates S1PR1-mediated hematopoietic stem and progenitor cell mobilization [0.03%]
四次跨膜蛋白CD82调节S1PR1介导的血液干细胞和前体细胞动员
Chelsea A Saito-Reis,Victoria D Balise,Erica M Pascetti et al.
Chelsea A Saito-Reis et al.
Hematopoietic stem and progenitor cell (HSPC) mobilization into the blood occurs under normal physiological conditions and is stimulated in the clinic to enable the isolation of HSPCs for transplantation therapies. In the present study, we ...
Ran Zheng,Ting Geng,Dan-Ya Wu et al.
Ran Zheng et al.
Published Erratum
Stem cell reports. 2021 Sep 14;16(9):2410-2414. DOI:10.1016/j.stemcr.2021.07.019 2021
High-throughput screening on cochlear organoids identifies VEGFR-MEK-TGFB1 signaling promoting hair cell reprogramming [0.03%]
耳器官的高通量筛选确定了促进毛细胞重编程的VEGFR-MEK-TGFB1信号路径
Qing Liu,Linqing Zhang,Min-Sheng Zhu et al.
Qing Liu et al.
Hair cell degeneration is a major cause of sensorineural hearing loss. Hair cells in mammalian cochlea do not spontaneously regenerate, posing a great challenge for restoration of hearing. Here, we establish a robust, high-throughput cochle...
Human stem cell-based retina on chip as new translational model for validation of AAV retinal gene therapy vectors [0.03%]
基于人类干细胞的视网膜芯片作为AAV视网膜基因治疗载体验证的新转化模型
Kevin Achberger,Madalena Cipriano,Matthias J Düchs et al.
Kevin Achberger et al.
Gene therapies using adeno-associated viruses (AAVs) are among the most promising strategies to treat or even cure hereditary and acquired retinal diseases. However, the development of new efficient AAV vectors is slow and costly, largely b...
Monica Piergiovanni,Ozlem Cangar,Sofia B Leite et al.
Monica Piergiovanni et al.
The European Commission Joint Research Centre and the European Standardization Organizations CEN and CENELEC organized the "Putting Science into Standards" workshop, focusing on organ-on-chip technologies. The workshop, held online on 28-29...
Interview of Don Ingber with Albert van den Berg and Andries van der Meer (University of Twente, the Netherlands, and EUROoCs board members) [0.03%]
Don Ingber 与 Albert van den Berg 和 Andries van der Meer(荷兰特文特大学教授和EUROoCs理事会成员)的访谈纪要
Don Ingber is the founding director of the Wyss Institute for Biologically Inspired Engineering at Harvard. His work has led to major advances in mechanobiology, cell structure, tumor angiogenesis, tissue engineering, systems biology, nanob...
Matthias Lutolf, interviewed by Peter Loskill (Vice-Chair of EUROoC, the European-Organ-on-Chip-Society) [0.03%]
Matthias Lutolf接受Peter Loskill采访（EUROoC副主席，欧洲芯片器官协会）
Matthias Lutolf is the scientific director of the Roche Institute for Translational Bioengineering and a full professor at the Institutes of Bioengineering and of Chemical Sciences and Engineering at École Polytechnique Fédérale de Lausa...
Challenging the pipeline [0.03%]
挑战线性模式
Peter Loskill,Rhiannon N Hardwick,Adrian Roth
Peter Loskill
This commentary presents a thought experiment seeking to answer the key question: "If you were to put aside all the traditional drug discovery processes and start a new drug discovery program that places the highest priority on human and di...
Christine Mummery,Peter Loskill
Christine Mummery
Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells [0.03%]
抗高血压药物治疗和人类PSC衍生的心肌细胞及初级内皮细胞对SARS-CoV-2感染的易感性
Jessika Iwanski,Sobhi G Kazmouz,Shuaizhi Li et al.
Jessika Iwanski et al.
The pathogenicity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been attributed to its ability to enter through the membrane-bound angiotensin-converting enzyme 2 (ACE2) receptor. Therefore, it has been heavily specula...