Long-term safety and clinical outcomes from a single-site phase 1 study of neural stem cell transplantation for chronic cervical spinal cord injury [0.03%]
一项自体神经干细胞移植治疗慢性颈椎脊髓损伤的I期临床研究的长期安全性和临床结果
Mickey E Abraham,Joel R Martin,Margaret Seaton et al.
Mickey E Abraham et al.
Neural stem cell transplantation offers a promising avenue for spinal cord injury (SCI) repair, but demonstrating safety and feasibility in human populations remains a critical step. In this phase 1 trial, we investigate the long-term outco...
Brian N Lee,Henry J Taylor,Filippo Cipriani et al.
Brian N Lee et al.
Induced pluripotent stem cells (iPSCs) enabled the generation of diverse cell types; however, certain fundamental biological properties, such as the genetic and epigenetic determinants of proliferation, remain poorly characterized. We quant...
Developmental dynamics of skeletal muscle can be recapitulated in vitro from pig embryonic stem cells [0.03%]
猪胚胎干细胞体外分化发育的肌发生动态过程
Jinsol Jeong,Kwang-Hwan Choi,Yelim Ahn et al.
Jinsol Jeong et al.
Given the value of pigs as a large-animal model bridging rodents and humans, a porcine in vitro system for skeletal muscle development is a prerequisite for advancing both fundamental and translational research. Here, we establish a stepwis...
Spatially resolved transcriptomics identifies intercellular signaling post-ischemic stroke that controls neural stem cell proliferation [0.03%]
空间分辨转录组学识别缺血性卒中后的细胞间信号传导以控制神经干细胞增殖
He Huang,Emerson Daniele,Wing Chung Jessie Lam et al.
He Huang et al.
Ischemic stroke mobilizes adult neural stem cells (NSCs), which could be leveraged for recovery. However, the intercellular signals that activate NSCs are poorly understood. Cells located in the cerebral lesion may send signals to the NSC n...
PrPC-facilitated cell signaling activates phospholipase Cɣ1 and triggers an Arc/Arg3.1 response in mouse and iPSC-derived human neurons [0.03%]
PrPC促进的细胞信号传导激活磷脂酶Cɣ1并触发小鼠和诱导多能干细胞衍生的人类神经元中的Arc/Arg3.1反应
Daniel Ojeda-Juarez,Gail Funk,Daniel B McClatchy et al.
Daniel Ojeda-Juarez et al.
Synapse loss is an early feature of prion disease, yet the underlying drivers are poorly understood. We recently found evidence of neuronal hyperactivity and synaptic loss in prion-infected mice. Herein, we identified increased Arc/Arg3.1 i...
Nanofiber-based platform for quantitative analysis of human oligodendrocyte ensheathment with pharmacological perturbations [0.03%]
基于纳米纤维的定量分析人少突胶质细胞包裹的技术平台及药理学干扰方法
Satoshi Morita,Takayuki Kondo,Keiko Imamura et al.
Satoshi Morita et al.
Oligodendrocytes are glial cells responsible for myelination in the central nervous system, and their dysfunction underlies various neurological disorders. However, existing human oligodendrocyte models are limited by low efficiency and ins...
Annika Wittich,Kim Krieg,Philip Gribbon et al.
Annika Wittich et al.
Organoids are self-organizing three-dimensional (3D) in vitro tissues derived from pluripotent stem cells (PSCs) that recapitulate key structural and functional features of human organs. Their multicellular architecture and physiological re...
Mitochondrial toxins cause widespread downregulation of pathways in X-linked dystonia-parkinsonism patient-derived neurons [0.03%]
线粒体毒素可导致遗传性扭转痉挛-帕金森病患者源神经元多种通路广泛下调
Karen Grütz,Axel Künstner,Christin Krause et al.
Karen Grütz et al.
The genetic mechanism underlying the neurodegenerative movement disorder X-linked dystonia-parkinsonism (XDP) involves a retrotransposon insertion within the TAF1 gene. TAF1 encodes the TATA-box binding protein-associated factor 1, the larg...
Therapeutic reactivation of hippocampal progenitors reverse cognition decline in mice with progressive brain demyelination [0.03%]
小鼠进行性脑脱髓鞘病变中后颅窝前体细胞的再激活可逆转认知衰退现象
Shiva Nemati,Seyed Mojtaba Hosseini,Maria Astrid Bravo-Jimenez et al.
Shiva Nemati et al.
Chronic brain demyelination and neurodegeneration are hallmarks of progressive multiple sclerosis (MS) that underlie cognitive impairments. Neural precursor cells (NPCs) in the hippocampus support cognition through neurogenesis. With MS chr...
TOE1 is a β-catenin interacting protein regulating the proliferation of hematopoietic cells through PAK2 modulation [0.03%]
TOE1是通过调节PAK2介导的造血细胞增殖的β-catenin相互作用蛋白
Hyun Park,Okan Sevim,Megan Wagstaff et al.
Hyun Park et al.
Acute myeloid leukemia (AML) is an aggressive hematological malignancy frequently exhibiting deregulated expression/activity/localization of the Wnt signaling mediator β-catenin. To derive more effective β-catenin targeting strategies, we...