Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3 [0.03%]
反应性星形胶质细胞由缺陷的自噬和代谢功能衰竭引起，在第三型额颞叶痴呆中造成神经毒性
Abinaya Chandrasekaran,Katarina Stoklund Dittlau,Giulia I Corsi et al.
Abinaya Chandrasekaran et al.
Frontotemporal dementia type 3 (FTD3), caused by a point mutation in the charged multivesicular body protein 2B (CHMP2B), affects mitochondrial ultrastructure and the endolysosomal pathway in neurons. To dissect the astrocyte-specific impac...
Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson's disease [0.03%]
多能干细胞衍生的多巴胺亚群模拟帕金森病中的选择性神经元退化
Tony Oosterveen,Pedro Garção,Emma Moles-Garcia et al.
Tony Oosterveen et al.
In Parkinson's disease (PD), substantia nigra (SN) dopaminergic (DA) neurons degenerate, while related ventral tegmental area (VTA) DA neurons remain relatively unaffected. Here, we present a methodology that directs the differentiation of ...
β-Adrenergic signaling induces Notch-mediated salivary gland progenitor cell control [0.03%]
β-肾上腺素能信号通过Notch介导的机制控制唾液腺前体细胞
X Wang,P Serrano Martinez,J H Terpstra et al.
X Wang et al.
β-Adrenergic signaling blockade is a mainstay of hypertension management. One percent of patients taking β-blockers develop reduced salivary gland (SG) function. Here we investigate the role of SG progenitor cells in β-blocker-induced hy...
TDG is a pig-specific epigenetic regulator with insensitivity to H3K9 and H3K27 demethylation in nuclear transfer embryos [0.03%]
TDG是一种对核移植胚胎中H3K9和H3K27去甲基化不敏感的猪特异性表观遗传调控因子
Xin Liu,Lu Chen,Tao Wang et al.
Xin Liu et al.
Pig cloning by somatic cell nuclear transfer (SCNT) frequently undergoes incomplete epigenetic remodeling during the maternal-to-zygotic transition, which leads to a significant embryonic loss before implantation. Here, we generated the fir...
Ethical issues and public communication in the development of cell-based treatments for COVID-19: Lessons from the pandemic [0.03%]
COVID-19细胞治疗开发过程中的伦理问题和公共沟通：来自疫情的教训
Leigh Turner,Megan Munsie,Aaron D Levine et al.
Leigh Turner et al.
The significant morbidity and mortality of coronavirus disease 19 (COVID-19) prompted a global race to develop new therapies. These include interventions using cell- or cell-derived products, several of which are being tested in well-design...
Direct reprogramming of human Sertoli cells into male germline stem cells with the self-renewal and differentiation potentials via overexpressing DAZL/DAZ2/BOULE genes [0.03%]
通过过表达DAZL/DAZ2/BOULE基因将人类支持细胞直接重编程为具有自我更新和分化潜能的男性生殖干细胞
Wenhui Zhang,Wei Chen,Yinghong Cui et al.
Wenhui Zhang et al.
We propose a new concept that human somatic cells can be converted to become male germline stem cells by the defined factors. Here, we demonstrated that the overexpression of DAZL, DAZ2, and BOULE could directly reprogram human Sertoli cell...
Defective autophagy and increased apoptosis contribute toward the pathogenesis of FKRP-associated muscular dystrophies [0.03%]
缺陷自噬和增加的细胞凋亡推动了与FKRP相关的肌肉营养不良症的发病机制
Carolina Ortiz-Cordero,Claudia Bincoletto,Neha R Dhoke et al.
Carolina Ortiz-Cordero et al.
Fukutin-related protein (FKRP) is a glycosyltransferase involved in glycosylation of alpha-dystroglycan (α-DG). Mutations in FKRP are associated with muscular dystrophies (MD) ranging from limb-girdle LGMDR9 to Walker-Warburg Syndrome (WWS...
Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells [0.03%]
视黄酸信号在心脏发育中的作用：应用于人类多能干细胞分化为心血管谱系中的应用
Alexandra Wiesinger,Gerard J J Boink,Vincent M Christoffels et al.
Alexandra Wiesinger et al.
Retinoic acid (RA) signaling plays an important role during heart development in establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and growth of the ventricular compact wall. RA is also utilized as a ...
Allele-specific gene editing to rescue dominant CRX-associated LCA7 phenotypes in a retinal organoid model [0.03%]
利用等位基因特异性基因编辑在视网膜类器官模型中挽救因CRX相关显性突变导致的LCA7表型
Kathleen R Chirco,Shereen Chew,Anthony T Moore et al.
Kathleen R Chirco et al.
Cases of Leber congenital amaurosis caused by mutations in CRX (LCA7) exhibit an early form of the disease and show signs of significant photoreceptor dysfunction and eventual loss. To establish a translational in vitro model system to stud...
LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury [0.03%]
通过体外基因转导过表达莲花进一步促进人类iPSC-NS/PC移植治疗脊髓损伤后的运动功能恢复
Shuhei Ito,Narihito Nagoshi,Yasuhiro Kamata et al.
Shuhei Ito et al.
Functional recovery is still limited mainly due to several mechanisms, such as the activation of Nogo receptor-1 (NgR1) signaling, when human induced pluripotent stem cell-derived neural stem/progenitor cells (hiPSC-NS/PC) are transplanted ...