In vitro expanded skeletal myogenic progenitors from pluripotent stem cell-derived teratomas have high engraftment capacity [0.03%]
来自多能干细胞衍生畸胎瘤的体外扩增骨骼肌母细胞具有高移植物容量
Ning Xie,Sabrina N Chu,Karim Azzag et al.
Ning Xie et al.
One major challenge in realizing cell-based therapy for treating muscle-wasting disorders is the difficulty in obtaining therapeutically meaningful amounts of engraftable cells. We have previously described a method to generate skeletal myo...
Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids [0.03%]
使用人多能干细胞来源的肺泡类器官对肺纤维化进行疾病建模
Takahiro Suezawa,Shuhei Kanagaki,Keita Moriguchi et al.
Takahiro Suezawa et al.
Although alveolar epithelial cells play a critical role in the pathogenesis of pulmonary fibrosis, few practical in vitro models exist to study them. Here, we established a novel in vitro pulmonary fibrosis model using alveolar organoids co...
CD62L expression level determines the cell fate of myeloid progenitors [0.03%]
CD62L的表达水平决定了髓样祖细胞的命运
Yusuke Ito,Fumio Nakahara,Yuki Kagoya et al.
Yusuke Ito et al.
Hematopoietic cells differentiate through several progenitors in a hierarchical manner, and recent single-cell analyses have revealed substantial heterogeneity within each progenitor. Although common myeloid progenitors (CMPs) are defined a...
RYBP modulates embryonic neurogenesis involving the Notch signaling pathway in a PRC1-independent pattern [0.03%]
RYBP通过独立于PRC1的方式调节Notch信号通路从而影响神经胚形成过程中的神经发生过程
Qian Li,Junchen Chen,Feng Liang et al.
Qian Li et al.
RYBP (Ring1 and YY1 binding protein), an essential component of the Polycomb repressive complex 1 (PRC1), plays pivotal roles in development and diseases. However, the roles of Rybp in neuronal development remains completely unknown. In the...
IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock [0.03%]
IL-18R介导的HSC静止期和MLKL依赖性细胞死亡限制了感染诱导性休克期间的血液生成
Jennifer E Howard,Julianne N P Smith,Gabrielle Fredman et al.
Jennifer E Howard et al.
Severe infection can dramatically alter blood production, but the mechanisms driving hematopoietic stem and progenitor cell (HSC/HSPC) loss have not been clearly defined. Using Ixodes ovatus Ehrlichia (IOE), a tick-borne pathogen that cause...
DPPA2, DPPA4, and other DPPA factor epigenomic functions in cell fate and cancer [0.03%]
DPPA2、DPPA4及其他DPPA因子在细胞命运及癌症中的表观基因组功能
Rachel Herndon Klein,Paul S Knoepfler
Rachel Herndon Klein
Many gene networks are shared between pluripotent stem cells and cancer; a concept exemplified by several DPPA factors such as DPPA2 and DPPA4, which are highly and selectively expressed in stem cells but also found to be reactivated in can...
Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons [0.03%]
单细胞转录组学鉴定SOD1 ALS诱导多能干细胞来源的运动神经元中神经退行性的主调控因子
Seema C Namboori,Patricia Thomas,Ryan Ames et al.
Seema C Namboori et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by the loss of motor neurons. We utilized single-cell transcriptomics to uncover dysfunctional pathways in degenerating motor neurons differentiated fr...
Upregulation of the JAK-STAT pathway promotes maturation of human embryonic stem cell-derived cardiomyocytes [0.03%]
JAK-STAT通路的激活促进人类胚胎干细胞来源的心肌细胞成熟
Beatrice Xuan Ho,Hongbing Yu,Jeremy Kah Sheng Pang et al.
Beatrice Xuan Ho et al.
The immature characteristics and metabolic phenotypes of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) restrict their applications for disease modeling, drug discovery, and cell-based therapy. Leveraging on the metabolic shi...
Weighing up the evidence used by direct-to-consumer stem cell businesses [0.03%]
面向消费者的干细胞企业所采用证据的评估
Margaret Cook,Alexandra Richey,David A Brafman et al.
Margaret Cook et al.
Hundreds of businesses across the United States offer direct-to-consumer stem-cell-based interventions that have not been approved by the Food and Drug Administration. Here, we characterize the types of evidence used on the websites of 59 s...
Human iPSC-derived hippocampal spheroids: An innovative tool for stratifying Alzheimer disease patient-specific cellular phenotypes and developing therapies [0.03%]
人iPSC来源的海马小球体：一种用于分层阿尔茨海默病患者特异性细胞表型和开发治疗手段的创新工具
Yuriy Pomeshchik,Oxana Klementieva,Jeovanis Gil et al.
Yuriy Pomeshchik et al.
Published Erratum
Stem cell reports. 2021 Nov 9;16(11):2838. DOI:10.1016/j.stemcr.2021.10.003 2021