The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2 [0.03%]
新冠肺炎患者的血脑屏障功能异常，并可能作为新冠病毒入侵中枢神经系统的途径
Susanne Krasemann,Undine Haferkamp,Susanne Pfefferle et al.
Susanne Krasemann et al.
Neurological complications are common in COVID-19. Although SARS-CoV-2 has been detected in patients' brain tissues, its entry routes and resulting consequences are not well understood. Here, we show a pronounced upregulation of interferon ...
Restoration of hippocampal neural precursor function by ablation of senescent cells in the aging stem cell niche [0.03%]
通过清除衰老干细胞生态位中的衰老细胞来恢复海马神经前体细胞功能
Michael P Fatt,Lina M Tran,Gisella Vetere et al.
Michael P Fatt et al.
Senescent cells are responsible, in part, for tissue decline during aging. Here, we focused on CNS neural precursor cells (NPCs) to ask if this is because senescent cells in stem cell niches impair precursor-mediated tissue maintenance. We ...
Physical exercise promotes integration of grafted cells and functional recovery in an acute stroke rat model [0.03%]
运动促进卒中急性期移植细胞整合及功能恢复：动物研究
Rui Wu,Yiping Guo,Liying Zhang et al.
Rui Wu et al.
Human neural progenitor cell (hNPC) transplantation holds great potential to treat neurological diseases. However, hNPC grafts take a long time to differentiate into mature neurons due to their intrinsically prolonged developmental timetabl...
Inducing human retinal pigment epithelium-like cells from somatic tissue [0.03%]
由体细胞诱导生成人类视网膜色素上皮样细胞
Ivo Ngundu Woogeng,Bogumil Kaczkowski,Imad Abugessaisa et al.
Ivo Ngundu Woogeng et al.
Regenerative medicine relies on basic research outcomes that are only practical when cost effective. The human eyeball requires the retinal pigment epithelium (RPE) to interface the neural retina and the choroid at large. Millions of people...
4D imaging analysis of the aging mouse neural stem cell niche reveals a dramatic loss of progenitor cell dynamism regulated by the RHO-ROCK pathway [0.03%]
基于RHO-ROCK通路的4D成像分析揭示了成年小鼠神经干细胞生态位中的前体细胞活力的大幅降低
Xiuli Zhao,Elizabeth S Fisher,Yue Wang et al.
Xiuli Zhao et al.
In the adult ventricular-subventricular zone (V-SVZ), neural stem cells (NSCs) give rise to transit-amplifying progenitor (TAP) cells. These progenitors reside in different subniche locations, implying that cell movement must accompany line...
PAX6-positive microglia evolve locally in hiPSC-derived ocular organoids [0.03%]
人诱导多能干细胞来源的眼球类器官中PAX6阳性的小胶质细胞局部增殖演变
Nobuhiko Shiraki,Kazuichi Maruyama,Ryuhei Hayashi et al.
Nobuhiko Shiraki et al.
Microglia are the resident immune cells of the central nervous system (CNS). They govern the immunogenicity of the retina, which is considered to be part of the CNS; however, it is not known how microglia develop in the eye. Here, we studie...
Tubastatin A maintains adult skeletal muscle stem cells in a quiescent state ex vivo and improves their engraftment ability in vivo [0.03%]
Tubastatin A使成年肌肉干细胞在体外维持静息状态并改善其体内植入能力
Marina Arjona,Armon Goshayeshi,Cristina Rodriguez-Mateo et al.
Marina Arjona et al.
Adult skeletal muscle stem cells (MuSCs) are important for muscle regeneration and constitute a potential source of cell therapy. However, upon isolation, MuSCs rapidly exit quiescence and lose transplantation potency. Maintenance of the qu...
Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury [0.03%]
利用DREADD技术揭示人iPSC来源的神经元活性在脊髓损伤后的治疗作用及其机制
Takahiro Kitagawa,Narihito Nagoshi,Yasuhiro Kamata et al.
Takahiro Kitagawa et al.
Transplantation of neural stem/progenitor cells (NS/PCs) derived from human induced pluripotent stem cells (hiPSCs) is considered to be a promising therapy for spinal cord injury (SCI) and will soon be translated to the clinical phase. Howe...
In vitro disease modeling of oculocutaneous albinism type 1 and 2 using human induced pluripotent stem cell-derived retinal pigment epithelium [0.03%]
利用人诱导多能干细胞源性视网膜色素上皮细胞体外模拟眼皮肤白化病1型和2型
Aman George,Ruchi Sharma,Tyler Pfister et al.
Aman George et al.
Oculocutaneous albinism (OCA) encompasses a set of autosomal recessive genetic conditions that affect pigmentation in the eye, skin, and hair. OCA patients display reduced best-corrected visual acuity, reduced to absent ocular pigmentation,...
DOT1L inhibition enhances pluripotency beyond acquisition of epithelial identity and without immediate suppression of the somatic transcriptome [0.03%]
抑制DOT1L可增强多能性，使其超越获得上皮细胞身份的阶段，并且不会立即抑制体细胞转录组
Coral K Wille,Rupa Sridharan
Coral K Wille
Inhibiting the histone 3 lysine 79 (H3K79) methyltransferase, disruptor of telomeric silencing 1-like (DOT1L), increases the efficiency of reprogramming somatic cells to induced pluripotent stem cells (iPSCs). Here, we find that, despite th...