Tissue origin of cytotoxic natural killer cells dictates their differential roles in mouse digit tip regeneration and progenitor cell survival [0.03%]
细胞毒性自然杀伤细胞的组织起源决定了其在小鼠指端再生和祖细胞存活中的不同作用
Nadjib Dastagir,Zachery Beal,James Godwin
Nadjib Dastagir
Regeneration of amputated digit tips relies on mesenchymal progenitor cells and their differentiation into replacement bone and tissue stroma. Natural killer (NK) cells have well-characterized roles in antigen-independent killing of virally...
Survival of an HLA-mismatched, bioengineered RPE implant in dry age-related macular degeneration [0.03%]
人遗体捐赠视网膜色素上皮细胞的生物工程化修饰及其异体移植治疗干性年龄相关黄斑变性的安全性研究
Amir H Kashani,Jane S Lebkowski,David R Hinton et al.
Amir H Kashani et al.
Cell-based therapies face challenges, including poor cell survival, immune rejection, and integration into pathologic tissue. We conducted an open-label phase 1/2a clinical trial to assess the safety and preliminary efficacy of a subretinal...
Clinical Trial
Stem cell reports. 2022 Mar 8;17(3):448-458. DOI:10.1016/j.stemcr.2022.01.001 2022
Reconstruction of dynamic regulatory networks reveals signaling-induced topology changes associated with germ layer specification [0.03%]
动态调节网络的重建揭示了信号传导诱导的与胚胎胚层分化相关的拓扑变化
Emily Y Su,Abby Spangler,Qin Bian et al.
Emily Y Su et al.
Elucidating regulatory relationships between transcription factors (TFs) and target genes is fundamental to understanding how cells control their identity and behavior. Unfortunately, existing computational gene regulatory network (GRN) rec...
Human iPSC model reveals a central role for NOX4 and oxidative stress in Duchenne cardiomyopathy [0.03%]
人多能干细胞模型揭示NOX4和氧化应激在杜氏肌营养不良心肌病中的核心作用
Robin Duelen,Domiziana Costamagna,Guillaume Gilbert et al.
Robin Duelen et al.
Duchenne muscular dystrophy (DMD) is a progressive muscle disorder caused by mutations in the Dystrophin gene. Cardiomyopathy is a major cause of early death. We used DMD-patient-specific human induced pluripotent stem cells (hiPSCs) to mod...
Selective elimination of pluripotent stem cells by PIKfyve specific inhibitors [0.03%]
PIKfyve特异抑制剂选择性清除多能干细胞
Arup R Chakraborty,Alex Vassilev,Sushil K Jaiswal et al.
Arup R Chakraborty et al.
Inhibition of PIKfyve phosphoinositide kinase selectively kills autophagy-dependent cancer cells by disrupting lysosome homeostasis. Here, we show that PIKfyve inhibitors can also selectively eliminate pluripotent embryonal carcinoma cells ...
Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes [0.03%]
利用同基因iPS细胞源心肌细胞模拟Plakophilin-2缺乏引起的心肌收缩力下降和桥粒装配障碍
Hiroyuki Inoue,Satoki Nakamura,Shuichiro Higo et al.
Hiroyuki Inoue et al.
Loss-of-function mutations in PKP2, which encodes plakophilin-2, cause arrhythmogenic cardiomyopathy (AC). Restoration of deficient molecules can serve as upstream therapy, thereby requiring a human model that recapitulates disease patholog...
CRISPR activation enables high-fidelity reprogramming into human pluripotent stem cells [0.03%]
基于CRISPR的转录激活系统实现精确重编程序化以形成人类多能干细胞
Joonas Sokka,Masahito Yoshihara,Jouni Kvist et al.
Joonas Sokka et al.
Conventional reprogramming methods rely on the ectopic expression of transcription factors to reprogram somatic cells into induced pluripotent stem cells (iPSCs). The forced expression of transcription factors may lead to off-target gene ac...
Multi-layered regulation of neuroectoderm differentiation by retinoic acid in a primitive streak-like context [0.03%]
类原条背景下视黄酸通过多层调节控制神经外胚层分化
Luigi Russo,Hanna L Sladitschek,Pierre A Neveu
Luigi Russo
The formation of the primitive streak (PS) and the subsequent induction of neuroectoderm are hallmarks of gastrulation. Combining an in vitro reconstitution of this process based on mouse embryonic stem cells (mESCs) with a collection of kn...
Reaching into the toolbox: Stem cell models to study neuropsychiatric disorders [0.03%]
干细胞模型在神经精神疾病研究中的应用
Jack T Whiteley,Sarah Fernandes,Amandeep Sharma et al.
Jack T Whiteley et al.
Recent advances in genetics, molecular biology, and stem cell biology have accelerated our understanding of neuropsychiatric disorders, like autism spectrum disorder (ASD), major depressive disorder (MDD), bipolar disorder (BD), and schizop...
YAP1 regulates the self-organized fate patterning of hESC-derived gastruloids [0.03%]
YAP1调节由人胚胎干细胞衍生的原肠胚类器官中的自我组织命运模式
Eleonora Stronati,Servando Giraldez,Ling Huang et al.
Eleonora Stronati et al.
The gastrulation process relies on complex interactions between developmental signaling pathways that are not completely understood. Here, we interrogated the contribution of the Hippo signaling effector YAP1 to the formation of the three g...