NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation [0.03%]
体外去除T细胞的单倍型相合造血干细胞移植中，自然杀伤(NK)细胞含量与植入无关
Pietro Merli,Thomas Eichholz,Maria Luigia Catanoso et al.
Pietro Merli et al.
A call for consensus guidelines on monitoring the integrity of nuclear and mitochondrial genomes in human pluripotent stem cells [0.03%]
关于在人类多能干细胞中监测核基因组和线粒体基因组完整性的共识指导方针的呼吁
Andrea Rossi,Selene Lickfett,Soraia Martins et al.
Andrea Rossi et al.
Despite the widespread use of human pluripotent stem cells (hPSCs), there is no general consensus with respect to monitoring the integrity of nuclear and mitochondrial genome of hPSCs. We argue that clear guidelines should be in place, and ...
Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells [0.03%]
一种分离干细胞来源的胰岛细胞亚群的方法的发展scalable method to isolate subsets of stem cell-derived pancreatic islet cells的中文名称是“一种分离干细胞来源的胰岛细胞亚群的方法的发展”
Audrey V Parent,Sudipta Ashe,Gopika G Nair et al.
Audrey V Parent et al.
Cell replacement therapy using β cells derived from stem cells is a promising alternative to conventional diabetes treatment options. Although current differentiation methods produce glucose-responsive β cells, they can also yield populat...
Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids [0.03%]
人诱导多能干细胞衍生胃类器官的粘膜肌层来源于上皮细胞
Keiichiro Uehara,Michiyo Koyanagi-Aoi,Takahiro Koide et al.
Keiichiro Uehara et al.
Human gastric development has not been well studied. The generation of human pluripotent stem cell-derived gastric organoids (hGOs) comprising gastric marker-expressing epithelium without an apparent smooth muscle (SM) structure has been re...
Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro [0.03%]
基因调控可减少供体干细胞来源的胰岛在体外培养中的凋亡
Nayara C Leite,Gabriela C Pelayo,Douglas A Melton
Nayara C Leite
The in vitro production of stem-cell-derived islets (SC-islets) has brought forth the potential of transplanting these cells to restore glycemic control in people with diabetes. Nonetheless, alloimmune and autoimmune responses remain consid...
Jessica L Shannon,David L Corcoran,John C Murray et al.
Jessica L Shannon et al.
Skin tissue regeneration after injury involves the production and integration of signals by stem cells residing in hair follicles (HFSCs). Much remains unknown about how specific wound-derived factors modulate stem cell contribution to hair...
A human pluripotent stem cell-based model of SARS-CoV-2 infection reveals an ACE2-independent inflammatory activation of vascular endothelial cells through TLR4 [0.03%]
基于人多能干细胞的SARS-CoV-2感染模型揭示了血管内皮细胞通过TLR4激活的ACE2独立炎症反应
Zhangjing Ma,Xisheng Li,Rebecca L Y Fan et al.
Zhangjing Ma et al.
To date, the direct causative mechanism of SARS-CoV-2-induced endotheliitis remains unclear. Here, we report that human ECs barely express surface ACE2, and ECs express less intracellular ACE2 than non-ECs of the lungs. We ectopically expre...
Long-term adherence of human brain cells in vitro is enhanced by charged amine-based plasma polymer coatings [0.03%]
基于胺的等离子聚合物涂层可增强人脑细胞的长期粘附性
Bridget Milky,Michael Zabolocki,Sameer A Al-Bataineh et al.
Bridget Milky et al.
Advances in cellular reprogramming have radically increased the use of patient-derived cells for neurological research in vitro. However, adherence of human neurons on tissue cultureware is unreliable over the extended periods required for ...
Inhibition of BMP signaling with LDN 193189 can influence bone marrow stromal cell fate but does not prevent hypertrophy during chondrogenesis [0.03%]
BMP信号转导的抑制剂LDN 193189对骨髓基质细胞的命运有影响，但不能在软骨生成过程中防止细胞肥大现象的发展
Rose Ann G Franco,Eamonn McKenna,Pamela G Robey et al.
Rose Ann G Franco et al.
Bone morphogenetic protein (BMP) cascades are upregulated during bone marrow-derived stromal cell (BMSC) chondrogenesis, contributing to hypertrophy and preventing effective BMSC-mediated cartilage repair. Previous work demonstrated that a ...
Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes [0.03%]
全基因组分析揭示SARS-CoV-2病毒基因Orf9c对人多能干细胞源心肌细胞的不利影响
Juli Liu,Yucheng Zhang,Lei Han et al.
Juli Liu et al.
Patients with coronavirus disease 2019 (COVID-19) commonly have manifestations of heart disease. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome encodes 27 proteins. Currently, SARS-CoV-2 gene-induced abnormalities of hu...