Regeneration of spermatogenesis by mouse germ cell transplantation into allogeneic and xenogeneic testis primordia or organoids [0.03%]
小鼠生殖细胞向同种和异种睾丸原基或类器官的移植及生殖细胞发生现象的研究
Mito Kanatsu-Shinohara,Narumi Ogonuki,Shogo Matoba et al.
Mito Kanatsu-Shinohara et al.
Gametogenesis requires close interactions between germ cells and somatic cells. Derivation of sperm from spermatogonial stem cells (SSCs) is hampered by the inefficiency of spermatogonial transplantation technique in many animal species bec...
SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids [0.03%]
SARS-CoV-2可感染和复制人视网膜类器官的光感受器及视网膜神经节细胞
Yotam Menuchin-Lasowski,André Schreiber,Aarón Lecanda et al.
Yotam Menuchin-Lasowski et al.
Several studies have pointed to retinal involvement in COVID-19, yet many questions remain regarding the ability of SARS-CoV-2 to infect and replicate in retinal cells and its effects on the retina. Here, we have used human pluripotent stem...
Deciphering heterogeneous populations of migrating cells based on the computational assessment of their dynamic properties [0.03%]
基于其动态属性的计算评估解密迁移细胞的异质种群
Aymeric Ferreira,Cedric Bressan,Simon V Hardy et al.
Aymeric Ferreira et al.
Neuronal migration is a highly dynamic process, and multiple cell movement metrics can be extracted from time-lapse imaging datasets. However, these parameters alone are often insufficient to evaluate the heterogeneity of neuroblast populat...
DDX41 is needed for pre- and postnatal hematopoietic stem cell differentiation in mice [0.03%]
DDX41对小鼠造血干细胞分化是必需的
Jing Ma,Nadim Mahmud,Maarten C Bosland et al.
Jing Ma et al.
DDX41 is a tumor suppressor frequently mutated in human myeloid neoplasms, but whether it affects hematopoiesis is unknown. Using a knockout mouse, we demonstrate that DDX41 is required for mouse hematopoietic stem and progenitor cell (HSPC...
Minjeong Shin,Meghan Ferguson,Reegan J Willms et al.
Minjeong Shin et al.
Intestinal progenitor cells integrate signals from their niche, and the gut lumen, to divide and differentiate at a rate that maintains an epithelial barrier to microbial invasion of the host interior. Despite the importance of evolutionari...
Synthetic developmental biology: Engineering approaches to guide multicellular organization [0.03%]
合成发育生物学：指导多细胞组织的工程方法
Ibrahim Zarkesh,Mohammad Kazemi Ashtiani,Zahra Shiri et al.
Ibrahim Zarkesh et al.
Multicellular organisms of various complexities self-organize in nature. Organoids are in vitro 3D structures that display important aspects of the anatomy and physiology of their in vivo counterparts and that develop from pluripotent or ti...
Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls [0.03%]
同型突变可能是半合突变了：CRISPR / Cas9编辑诱导的人iPSC中的有害靶向缺陷可逃逸标准质量控制检测
Dina Simkin,Vasileios Papakis,Bernabe I Bustos et al.
Dina Simkin et al.
The ability to precisely edit the genome of human induced pluripotent stem cell (iPSC) lines using CRISPR/Cas9 has enabled the development of cellular models that can address genotype to phenotype relationships. While genome editing is beco...
Niclosamide induces miR-148a to inhibit PXR and sensitize colon cancer stem cells to chemotherapy [0.03%]
niclosamide通过诱导miR-148a抑制PXR从而提高化疗药物对结直肠癌干细胞的杀伤作用
Lucile Bansard,Océane Bouvet,Elisa Moutin et al.
Lucile Bansard et al.
Tumor recurrence is often attributed to cancer stem cells (CSCs). We previously demonstrated that down-regulation of Pregnane X Receptor (PXR) decreases the chemoresistance of CSCs and prevents colorectal cancer recurrence. Currently, no PX...
Aging of intestinal stem cells [0.03%]
肠干细胞老化
Kodandaramireddy Nalapareddy,Yi Zheng,Hartmut Geiger
Kodandaramireddy Nalapareddy
The intestine is one of the organs that relies on stem cell function for maintaining tissue homeostasis. Recent findings on intestinal aging show that intestinal architecture, such as villus length, crypt size, and cell composition changes ...
Response to NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation [0.03%]
供者NK细胞含量与体外去除T细胞的单倍型移植无关
Lorena Lobo de Figueiredo-Pontes,Miroslava K Adamcova,Robert S Welner et al.
Lorena Lobo de Figueiredo-Pontes et al.