Davide Marotta,Noor Ward,Steven R Bauer et al.
Davide Marotta et al.
This perspective article explores the transformative potential of biomanufacturing in low Earth orbit (LEO) for regenerative medicine. Building on key symposia and workshops, it highlights the International Space Station (ISS) National Labo...
Cholinergic neuron-to-glioblastoma synapses in a human iPSC-derived co-culture model [0.03%]
人多能干细胞来源的神经元-胶质母细胞瘤共培养模型中的胆碱能神经元-胶质母细胞瘤突触
Yusha Sun,Xin Wang,Zhijian Zhang et al.
Yusha Sun et al.
Glioblastoma (GBM) integrates extensively into brain-wide neuronal circuits; however, neuron-tumor interactions have largely been studied with glutamatergic neurons in animal models. The role of neuromodulatory circuits for GBM biology in a...
Promoting the adoption of best practices and standards to enhance quality and reproducibility of stem cell research [0.03%]
推广最佳实践和标准以提升干细胞研究的质量和可重复性
Lucia Selfa Aspiroz,Milena Mennecozzi,Laura Batlle et al.
Lucia Selfa Aspiroz et al.
Advancing the use of human stem cell-based models on preclinical and regulatory testing fields requires the performance of rigorous and reproducible research. Quality standards and reporting best practices should be promoted to ensure the r...
Neural stem cells of the subventricular zone: A potential stem cell pool for brain repair in Parkinson's disease [0.03%]
侧脑室下区的神经干细胞：帕金森病大脑修复的潜在干细胞池
Marloes Verkerke,Maarten H Werkman,Vanessa Donega
Marloes Verkerke
Parkinson's disease is a neurodegenerative disease caused by the degeneration of dopaminergic neurons in the substantia nigra. There are no curative treatments, and therefore, there is an urgent need for new approaches. One potential strate...
James E Mason,Xiaokai Nie,Daniel Coca et al.
James E Mason et al.
Heterogeneity of gene expression is a characteristic of stem cell populations. Here, we review our own findings with human pluripotent stem cells, emphasizing their capacity to occupy distinct metastable substates that influence their diffe...
Stem cell-based embryo models: The 2021 ISSCR stem cell guidelines revisited [0.03%]
基于干细胞的胚胎模型：2021年ISSCR干细胞指导原则再议
Amander T Clark,Heidi Cook-Andersen,Sarah Franklin et al.
Amander T Clark et al.
Human stem cell-based embryo models (SCBEMs) are a research technology with the potential to facilitate our understanding of human embryogenesis, improve assisted reproductive technology outcomes, elucidate the causes of early pregnancy fai...
GSK3α negatively regulates GSK3β by decreasing its protein levels and enzymatic activity in mouse embryonic stem cells [0.03%]
GSK3α通过降低其蛋白水平和酶活性抑制GSK3β在胚胎干细胞中的作用
Duo Wang,Xi Chen,Joshua Feng et al.
Duo Wang et al.
Glycogen synthase kinase 3 (GSK3) is a crucial regulator of cellular processes, including stem cell maintenance and differentiation. Although the roles of the two GSK3 isozymes, GSK3α and GSK3β, are well documented, their specific interac...
Engineering the next generation of allogeneic CAR cells: iPSCs as a scalable and editable platform [0.03%]
下一代同种异体CAR细胞的工程化：作为可扩展和可编辑平台的诱导多能干细胞
Ying Fang,Yuning Chen,Yan-Ruide Li
Ying Fang
Over the past five years, allogeneic off-the-shelf CAR-engineered cell therapies have advanced rapidly. By bypassing the individualized manufacturing, high cost, and eligibility constraints of autologous products, allogeneic platforms, espe...
BMAL1 Deficiency Contributes to Mandibular Dysplasia by Upregulating MMP3 [0.03%]
BMAL1通过上调MMP3参与下颌发育不良
Jiajia Zhao,Xin Zhou,Qingming Tang et al.
Jiajia Zhao et al.
Published Erratum
Stem cell reports. 2025 Jun 4:102541. DOI:10.1016/j.stemcr.2025.102541 2025
Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration [0.03%]
谱系示踪显示SOX9阳性肝细胞在肝脏再生过程中的双分化潜能
Ximeng Han,Yue Wang,Wenjuan Pu et al.
Ximeng Han et al.
Published Erratum
Stem cell reports. 2025 Jun 4:102548. DOI:10.1016/j.stemcr.2025.102548 2025