CD157+ vascular endothelial stem cells represent a conserved subpopulation with an angiogenic gene expression profile [0.03%]
CD157阳性血管内皮干细胞代表一群保守的具有促血管生成基因表达谱的亚群细胞
Tomohiro Iba,Taku Wakabayashi,Rie Ito et al.
Tomohiro Iba et al.
Endothelial cells expressing the CD157 antigen (CD157+ ECs) contribute to vascular regeneration and maintenance in adult tissues, but their molecular identity is not fully defined. Here, we show that CD157-positive ECs in mouse and human ti...
PCBP1 orchestrates amino acid metabolism burst during the naïve-to-primed pluripotency transition [0.03%]
PCBP1在naïve到primed多能性转换期间调控氨基酸代谢爆发
Evgeny I Bakhmet,Evgeniy V Potapenko,Oleg Y Shuvalov et al.
Evgeny I Bakhmet et al.
Embryo implantation is accompanied by the naïve-to-primed pluripotency state transition in epiblast cells-the process involving proliferation and anabolic boost, needed for extensive embryo growth. Here, we show that Pcbp1 knockout leads t...
Intravenous immunoglobulin enhances intestinal stem cell regeneration to mitigate radiation-induced enteritis via promoting β-catenin nuclear translocation [0.03%]
静脉用免疫球蛋白通过促进β-连环素核转位增强肠道干细胞再生以缓解放射性肠炎
Jia He,Tiancheng Chu,Ping Fu et al.
Jia He et al.
Radiation-induced enteritis (RIE), a common adverse effect after radiotherapy for pelvic, abdominal, and retroperitoneal tumors, has no effective treatment. Our previous study showed that intravenous immunoglobulin (IVIg) ameliorated radiat...
Functional maturation of enteric neurons derived from human induced pluripotent stem cells [0.03%]
功能成熟的源自人类诱导多能干细胞的肠神经元
Eve S Rowland,Maciej Daniszewski,Caio Seguin et al.
Eve S Rowland et al.
The enteric nervous system (ENS) plays a crucial role in regulating gastrointestinal function, including motility, secretion, and absorption. Enteric neurons and glia derived from human induced pluripotent stem cells (iPSCs) have vast appli...
Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b [0.03%]
过表达Dnmt3b可减少半克隆小鼠的同核化并提高其存活率
Wenteng He,Xiaobai Zhang,Yalin Zhang et al.
Wenteng He et al.
Published Erratum
Stem cell reports. 2026 Jun 3:102974. DOI:10.1016/j.stemcr.2026.102974 2026
Pengyi Yang
Pengyi Yang
Cell fate programming enables applications in disease modeling, drug discovery, and regenerative medicine. Foundational studies established differentiation protocols, but their scalability is constrained by combinatorial complexity. Computa...
ZFHX4 is necessary for dopaminergic neuron differentiation and controls cell cycle by regulating LIN28A [0.03%]
zfhx4通过调节lin28a控制细胞周期并在多巴胺神经元分化中起重要作用
Elena Valceschini,Borja Gomez Ramos,Jochen Ohnmacht et al.
Elena Valceschini et al.
Parkinson's disease (PD) involves selective degeneration of midbrain dopaminergic neurons (mDANs), yet the regulatory networks governing their development remain incompletely understood. ZFHX4 has been linked to neurodevelopment across spec...
miR-151-5p regulates neural stem cell fate by targeting APH1A to modulate Notch signaling gradients [0.03%]
微RNA-151-5p通过靶向APH1A调节 notch信号梯度从而调控神经干细胞的命运决定
Xinrun Wang,Li Li,Zhuo Chen et al.
Xinrun Wang et al.
The precise regulation of neural stem cell (NSC) fate is fundamental to neocortical development. MicroRNAs (miRNAs) are critical post-transcriptional regulators in this process, yet the functions of many remain unknown. Here, we found miR-1...
NFATC1 dysfunction-triggered MSC senescence induces tooth aging amenable to senolytic therapy [0.03%]
NFATC1功能障碍触发的间充质干细胞衰老导致可进行senolytic治疗的牙齿衰老
Feifei Li,Changhao Yu,Lin Yao et al.
Feifei Li et al.
Organ-specific aging drivers extend our understanding of aging and offer therapeutic potential for combating age-related decline and rejuvenating organ function. Mature mammalian teeth possess unique characteristics, cell-free calcified par...
Direct Generation of Human Neuronal Cells from Adult Astrocytes by Small Molecules [0.03%]
小分子直接将成人星形胶质细胞转分化为人类神经元细胞
Longfei Gao,Wuqiang Guan,Min Wang et al.
Longfei Gao et al.
Published Erratum
Stem cell reports. 2026 May 21:102961. DOI:10.1016/j.stemcr.2026.102961 2026