Generation of SIV-resistant T cells and macrophages from nonhuman primate induced pluripotent stem cells with edited CCR5 locus [0.03%]
通过编辑非人灵长类诱导多能干细胞CCR5位点生成抗SIV的T细胞和巨噬细胞
Saritha S D&#x;Souza,Akhilesh Kumar,Jason Weinfurter et al.
Saritha S D&#x;Souza et al.
Adoptive therapies with genetically modified somatic T cells rendered HIV resistance have shown promise for AIDS therapy. A renewable source of HIV-resistant human T cells from induced pluripotent stem cells (iPSCs) would further facilitate...
GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation [0.03%]
GP2富集的胰腺祖细胞可体内分化产生功能性β细胞并消除畸胎瘤风险
Yasaman Aghazadeh,Farida Sarangi,Frankie Poon et al.
Yasaman Aghazadeh et al.
Human pluripotent stem cell (hPSC)-derived pancreatic progenitors (PPs) can be differentiated into beta-like cells in vitro and in vivo and therefore have therapeutic potential for type 1 diabetes (T1D) treatment. However, the purity of PPs...
Functional redundancy among Polycomb complexes in maintaining the pluripotent state of embryonic stem cells [0.03%]
Polycomb蛋白复合体在胚胎干细胞多能性维持中的功能冗余性研究
Yaru Zhu,Lixia Dong,Congcong Wang et al.
Yaru Zhu et al.
Polycomb group proteins assemble into multi-protein complexes, known as Polycomb repressive complexes 1 and 2 (PRC1 and PRC2), that guide cell fate decisions during embryonic development. PRC1 forms an array of biochemically distinct canoni...
WNT16B enhances the proliferation and self-renewal of limbal epithelial cells via CXCR4/MEK/ERK signaling [0.03%]
WNT16B通过CXCR4/MEK/ERK信号促进睑板上皮细胞的增殖和自我更新
Songjiao Zhao,Xichen Wan,Yiqin Dai et al.
Songjiao Zhao et al.
Culture of limbal epithelial cells (LECs) provides the principal source of transplanted limbal stem cells (LESCs) for treatment of limbal-stem-cell deficiency. Optimization of the culture conditions for in-vitro-expanded LECs will help to c...
Substance P/neurokinin-1 receptor pathway blockade ameliorates limbal stem cell deficiency by modulating mTOR pathway and preventing cell senescence [0.03%]
通过调节mTOR途径和防止细胞衰老来改善角膜缘干细胞缺陷的P物质/神经激肽-1受体通路阻断作用
Romina Lasagni Vitar,Francesca Triani,Marco Barbariga et al.
Romina Lasagni Vitar et al.
Severe ocular surface diseases can lead to limbal stem cell deficiency (LSCD), which is accompanied by defective healing. We aimed to evaluate the role of the substance P (SP)/neurokinin-1 receptor (NK1R) pathway in corneal epithelium wound...
Friederike Matheus,Tal Raveh,Anthony E Oro et al.
Friederike Matheus et al.
The manipulation of human leukocyte antigens (HLAs) and immune modulatory factors in "universal" human pluripotent stem cells (PSCs) holds promise for immunological tolerance without HLA matching. This paradigm raises concerns should "unive...
Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitro [0.03%]
人脊髓前神经祖细胞的体外rostrocaudal模式和神经嵴分化
Fay Cooper,George E Gentsch,Richard Mitter et al.
Fay Cooper et al.
The spinal cord emerges from a niche of neuromesodermal progenitors (NMPs) formed and maintained by WNT/fibroblast growth factor (FGF) signals at the posterior end of the embryo. NMPs can be generated from human pluripotent stem cells and h...
Antioxidant and lipid supplementation improve the development of photoreceptor outer segments in pluripotent stem cell-derived retinal organoids [0.03%]
抗氧化剂和脂质的补充可以改善多能干细胞衍生视网膜类器官中光感受器外节的发育
Emma L West,Paromita Majumder,Arifa Naeem et al.
Emma L West et al.
The generation of retinal organoids from human pluripotent stem cells (hPSC) is now a well-established process that in part recapitulates retinal development. However, hPSC-derived photoreceptors that exhibit well-organized outer segment st...
Transcriptional profiling of β-2M-SPα-6+THY1+ spermatogonial stem cells in human spermatogenesis [0.03%]
人精子发生中β-2M-SPα-6+THY1+β-2微球蛋白干细胞转录分析
Maelle Givelet,Virginie Firlej,Bruno Lassalle et al.
Maelle Givelet et al.
Male infertility is responsible for approximately half of all cases of reproductive issues. Spermatogenesis originates in a small pool of spermatogonial stem cells (SSCs), which are of interest for therapy of infertility but remain not well...
Ranolazine rescues the heart failure phenotype of PLN-deficient human pluripotent stem cell-derived cardiomyocytes [0.03%]
恩拉扎林能够挽救PLN缺陷的人多能干细胞源心肌细胞的心力衰竭表型
Youxu Jiang,Xiaowei Li,Tianwei Guo et al.
Youxu Jiang et al.
Phospholamban (PLN) is a key regulator that controls the function of the sarcoplasmic reticulum (SR) and is required for the regulation of cardiac contractile function. Although PLN-deficient mice demonstrated improved cardiac function, PLN...