Financial risks posed by unproven cell interventions: Estimation of refunds from medical expense deductions in Japan [0.03%]
日本细胞干预的财务风险：对医疗费用减免退款的估算
Taichi Hatta,Kazuki Ide,Misao Fujita et al.
Taichi Hatta et al.
Master et al. (2021) declared that the unproven stem cell intervention (SCI) industry is a global health problem. We fully agree with this opinion but would like to point out that there are financial risks. In this letter, we estimate the t...
Hang Zhao,Xuejing Ren,Ruiyan Kong et al.
Hang Zhao et al.
Adult tissue homeostasis is maintained by residential stem cells. The proliferation and differentiation of adult stem cells must be tightly balanced to avoid excessive proliferation or premature differentiation. However, how stem cell proli...
Genome-wide screening for genes involved in the epigenetic basis of fragile X syndrome [0.03%]
全基因组筛选与弗莱格勒X染色体综合症表观遗传基础有关的基因
Dan Vershkov,Atilgan Yilmaz,Ofra Yanuka et al.
Dan Vershkov et al.
Fragile X syndrome (FXS), the most prevalent heritable form of intellectual disability, is caused by the transcriptional silencing of the FMR1 gene. The epigenetic factors responsible for FMR1 inactivation are largely unknown. Here, we init...
Engineered three-dimensional cardiac tissues maturing in a rotating wall vessel bioreactor remodel diseased hearts in rats with myocardial infarction [0.03%]
工程化的心肌组织修复心梗大鼠模型中的心脏病变
Taro Nakazato,Takuji Kawamura,Toshimasa Uemura et al.
Taro Nakazato et al.
A rotating wall vessel (RWV) bioreactor was constructed for growing massive functional cardiac constructs to recover the function of a distressed rat heart. Three-dimensional cardiac tissues were engineered by seeding human-induced pluripot...
Generating functional cells through enhanced interspecies chimerism with human pluripotent stem cells [0.03%]
利用人多能干细胞增强种间嵌合体以生成功能细胞
Yanling Zhu,Zhishuai Zhang,Nana Fan et al.
Yanling Zhu et al.
Obtaining functional human cells through interspecies chimerism with human pluripotent stem cells (hPSCs) remains unsuccessful due to its extremely low efficiency. Here, we show that hPSCs failed to differentiate and contribute teratoma in ...
TIN2 deficiency leads to ALT-associated phenotypes and differentiation defects in embryonic stem cells [0.03%]
TIN2缺陷导致胚胎干细胞出现与ALT相关表型及分化障碍
Shanshan Yin,Fangyingnan Zhang,Song Lin et al.
Shanshan Yin et al.
Telomere integrity is critical for embryonic development, and core telomere-binding proteins, such as TIN2, are key to maintaining telomere stability. Here, we report that homozygous Tin2S341X resulted in embryonic lethality in mice and red...
Diversifying stem cell debates: Including Muslim contexts and perspectives [0.03%]
多元化的干细胞争论：包含穆斯林语境与观点
Rana Dajani,Bashir Jiwani,Azim Nanji et al.
Rana Dajani et al.
Greater transcultural and transdisciplinary engagement within Muslim contexts and deliberate inclusion of diverse Muslim voices in the development of international guidelines is required to improve understanding of the state of stem cell sc...
Acquisition of NOTCH dependence is a hallmark of human intestinal stem cell maturation [0.03%]
NOTCH依赖性的获得是人类肠干细胞成熟的一大标志
Yu-Hwai Tsai,Angeline Wu,Joshua H Wu et al.
Yu-Hwai Tsai et al.
NOTCH signaling is a key regulator involved in maintaining intestinal stem cell (ISC) homeostasis and for balancing differentiation. Using single-cell transcriptomics, we observed that OLFM4, a NOTCH target gene present in ISCs, is first ex...
Cpmer: A new conserved eEF1A2-binding partner that regulates Eomes translation and cardiomyocyte differentiation [0.03%]
Cpmer：一种新的保守的eEF1A2结合伴侣，通过调节Eomes翻译和心肌细胞分化发挥作用
Yao Lyu,Wenwen Jia,Yukang Wu et al.
Yao Lyu et al.
Previous studies have shown that eukaryotic elongation factor 1A2 (eEF1A2) serves as an essential heart-specific translation elongation element and that its mutation or knockout delays heart development and causes congenital heart disease a...
RARG S427L attenuates the DNA repair response to doxorubicin in induced pluripotent stem cell-derived cardiomyocytes [0.03%]
RARG S427L通过诱导多能干细胞来源的心肌细胞减弱多柔比星的DNA修复反应
Haojun Huang,Effimia Christidi,Sanam Shafaattalab et al.
Haojun Huang et al.
Doxorubicin is a commonly used chemotherapeutic drug, but its use is limited by doxorubicin-induced cardiotoxicity (DIC), which can lead to irreversible heart failure and death. A missense variant rs2229774 (p.S427L) in the retinoic acid re...