Martin F Pera
Martin F Pera
Pluripotent stem cells provide a powerful model for the study of human development and its disorders. Recent studies, including two in this issue of Stem Cell Reports, raise important questions concerning the developmental potential of huma...
Melissa Little
Melissa Little
Fibroblast fate determination during cardiac reprogramming by remodeling of actin filaments [0.03%]
成纤维细胞重编程为心脏细胞的过程中肌动蛋白丝重塑对细胞命运决定的影响
Zhentao Zhang,Wenhui Zhang,Robert Blakes et al.
Zhentao Zhang et al.
Fibroblasts can be reprogrammed into induced cardiomyocyte-like cells (iCMs) by forced expression of cardiogenic transcription factors. However, it remains unknown how fibroblasts adopt a cardiomyocyte (CM) fate during their spontaneous ong...
Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting [0.03%]
基于microRNA的调控开关和磁性激活细胞分选的人诱导多能干细胞衍生细胞的大规模纯化技术
Yuta Tsujisaka,Takeshi Hatani,Chikako Okubo et al.
Yuta Tsujisaka et al.
For regenerative cell therapies using pluripotent stem cell (PSC)-derived cells, large quantities of purified cells are required. Magnetic-activated cell sorting (MACS) is a powerful approach to collect target antigen-positive cells; howeve...
Arp2/3 complex activity is necessary for mouse ESC differentiation, times formative pluripotency, and enables lineage specification [0.03%]
ARPC复合体活性对小鼠胚胎干细胞分化、维持基础多能性以及谱系特化是必需的
Francesca M Aloisio,Diane L Barber
Francesca M Aloisio
Mouse embryonic stem cells (mESCs), a model for differentiation into primed epiblast-like cells (EpiLCs), have revealed transcriptional and epigenetic control of early embryonic development. The control and significance of morphological cha...
Intrinsic neural stem cell properties define brain hypersensitivity to genotoxic stress [0.03%]
固有的神经干细胞特性定义了大脑对基因毒性应激的高敏感性
Argyro Kalogeropoulou,Maria Mougkogianni,Marianna Iliadou et al.
Argyro Kalogeropoulou et al.
Impaired replication has been previously linked to growth retardation and microcephaly; however, why the brain is critically affected compared with other organs remains elusive. Here, we report the differential response between early neural...
Yathindar Giffin-Rao,Jie Sheng,Bennett Strand et al.
Yathindar Giffin-Rao et al.
Individuals with Down syndrome (DS; Ts21), the most common genetic cause of intellectual disability, have smaller brains that reflect fewer neurons at pre- and post-natal stages, implicating impaired neurogenesis during development. Our ste...
Autism NPCs from both idiopathic and CNV 16p11.2 deletion patients exhibit dysregulation of proliferation and mitogenic responses [0.03%]
自闭症病人的NPCs（无论是原因不明还是由于16p11.2缺失）均表现出增殖及促分裂反应的失调现象
Robert Connacher,Madeline Williams,Smrithi Prem et al.
Robert Connacher et al.
Neural precursor cell (NPC) dysfunction has been consistently implicated in autism. Induced pluripotent stem cell (iPSC)-derived NPCs from two autism groups (three idiopathic [I-ASD] and two 16p11.2 deletion [16pDel]) were used to investiga...
Notch1 signaling in keratocytes maintains corneal transparency by suppressing VEGF expression [0.03%]
诺特金1信号在角膜细胞中通过抑制VEGF的表达来维持角膜透明性
Soma Biswas,Md Shafiquzzaman,Guo Yu et al.
Soma Biswas et al.
The cornea fends off chemicals, dirt, and infectious particles and provides most of the eye's focusing power. Corneal transparency is of paramount importance to normal vision, yet how it is established and maintained remains unclear. Here, ...
The product of BMP-directed differentiation protocols for human primed pluripotent stem cells is placental trophoblast and not amnion [0.03%]
人源化滋养外胚层的体外分化模型及其在筛选抗病毒药物中的应用
Arun S Seetharam,Ha T H Vu,Sehee Choi et al.
Arun S Seetharam et al.
The observation that trophoblast (TB) can be generated from primed pluripotent stem cells (PSCs) by exposure to bone morphogenetic protein-4 (BMP4) when FGF2 and ACTIVIN signaling is minimized has recently been challenged with the suggestio...