Involvement of LIN28A in Wnt-dependent regulation of hippocampal neurogenesis in the aging brain [0.03%]
LIN28A参与Wnt依赖的衰老大脑海马神经发生调节
Zhechun Hu,Jiao Ma,Huimin Yue et al.
Zhechun Hu et al.
Hippocampal neurogenesis declines with aging. Wnt ligands and antagonists within the hippocampal neurogenic niche regulate the proliferation of neural progenitor cells and the development of new neurons, and the changes of their levels in t...
Zika virus induces FOXG1 nuclear displacement and downregulation in human neural progenitors [0.03%]
寨卡病毒诱导人神经前体细胞中FOXG1的核转移及下调
Giulia Lottini,Matteo Baggiani,Giulia Chesi et al.
Giulia Lottini et al.
Congenital alterations in the levels of the transcription factor Forkhead box g1 (FOXG1) coding gene trigger "FOXG1 syndrome," a spectrum that recapitulates birth defects found in the "congenital Zika syndrome," such as microcephaly and oth...
Dissecting signaling hierarchies in the patterning of the mouse primitive streak using micropatterned EpiLC colonies [0.03%]
利用微图案EpiLC菌落分析小鼠原始条纹图式形成的信号层级关系
Jean-Louis Plouhinec,Gaël Simon,Mathieu Vieira et al.
Jean-Louis Plouhinec et al.
Embryo studies have established that the patterning of the mouse gastrula depends on a regulatory network in which the WNT, BMP, and NODAL signaling pathways cooperate, but aspects of their respective contributions remain unclear. Studying ...
CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells [0.03%]
CD49b识别分化偏向的谱系偏倚型造血干细胞中的功能和表观遗传学上不同的亚群
Ece Somuncular,Julia Hauenstein,Prajakta Khalkar et al.
Ece Somuncular et al.
Hematopoiesis is maintained by functionally diverse lineage-biased hematopoietic stem cells (HSCs). The functional significance of HSC heterogeneity and the regulatory mechanisms underlying lineage bias are not well understood. However, abs...
Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem cell-derived retinal ganglion cells [0.03%]
OPTN(E50K)人源干细胞来源的视网膜神经节细胞中，星形胶质细胞调节与青光眼相关的神经退行性表型
Cátia Gomes,Kirstin B VanderWall,Yanling Pan et al.
Cátia Gomes et al.
Although the degeneration of retinal ganglion cells (RGCs) is a primary characteristic of glaucoma, astrocytes also contribute to their neurodegeneration in disease states. Although studies often explore cell-autonomous aspects of RGC neuro...
Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film [0.03%]
睡眠剥夺通过破坏泪膜中的氧化还原稳态诱导角膜上皮干细胞过度扩增
Sanming Li,Liying Tang,Jing Zhou et al.
Sanming Li et al.
Published Erratum
Stem cell reports. 2022 Jun 14;17(6):1507-1508. DOI:10.1016/j.stemcr.2022.05.007 2022
Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation [0.03%]
用于临床治疗的基于干细胞分化而来的视网膜色素上皮细胞的分子图谱分析
Sandra Petrus-Reurer,Alex R Lederer,Laura Baqué-Vidal et al.
Sandra Petrus-Reurer et al.
Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) are a promising cell source to treat age-related macular degeneration (AMD). Despite several ongoing clinical studies, a detailed mapping of transient cellular st...
Urban Lendahl
Urban Lendahl
The International Society for Stem Cell Research (ISSCR) celebrates its 20th anniversary in 2022. This review looks back at some of the key developments in stem cell research as well as the evolution of the ISSCR as part of that field. Impo...
The need for a standard for informed consent for collection of human fetal material [0.03%]
有关采集人类胎儿材料的知情同意的标准的需求
Roger A Barker,Gerard J Boer,Elena Cattaneo et al.
Roger A Barker et al.
The ISSCR has developed the Informed Consent Standards for Human Fetal Tissue Donation and Research to promote uniformity and transparency in tissue donation and collection. This standard is designed to assist those working with and oversee...
ISSCR Presidents look back on their presidency, the evolution of the field, and the Society [0.03%]
ISSCR主席回望他们的任期、领域的发展以及学会的成长
In celebration of the ISSCR's 20th anniversary we asked past ISSCR presidents the question, "During your presidential year, what key achievements or issue(s) in the field stood out to you?" The collection of responses provides a glimpse of ...