Vascular defects associated with hereditary hemorrhagic telangiectasia revealed in patient-derived isogenic iPSCs in 3D vessels on chip [0.03%]
用于芯片上3D血管的同种异体诱导多能干细胞揭示与遗传性出血性血管瘤相关联的血管缺陷
Valeria V Orlova,Dennis M Nahon,Amy Cochrane et al.
Valeria V Orlova et al.
Hereditary hemorrhagic telangiectasia (HHT) is a genetic disease characterized by weak blood vessels. HHT1 is caused by mutations in the ENDOGLIN (ENG) gene. Here, we generated induced pluripotent stem cells (hiPSCs) from a patient with rar...
The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis [0.03%]
调控破骨细胞生成及骨稳态的间充质干细胞中的CDK8的作用机制研究
Takanori Yamada,Kazuya Fukasawa,Tetsuhiro Horie et al.
Takanori Yamada et al.
Bone marrow mesenchymal stem cells (MSCs) are critical regulators of postnatal bone homeostasis. Osteoporosis is characterized by bone volume and strength deterioration, partly due to MSC dysfunction. Cyclin-dependent kinase 8 (CDK8) belong...
Transient DUX4 expression in human embryonic stem cells induces blastomere-like expression program that is marked by SLC34A2 [0.03%]
人胚胎干细胞中DUX4的瞬时表达诱导类似合子基因激活的转录程序并由SLC34A2标记
Masahito Yoshihara,Ida Kirjanov,Sonja Nykänen et al.
Masahito Yoshihara et al.
Embryonic genome activation (EGA) is critical for embryonic development. However, our understanding of the regulatory mechanisms of human EGA is still incomplete. Human embryonic stem cells (hESCs) are an established model for studying deve...
Small-molecule inhibitor cocktail promotes the proliferation of pre-existing liver progenitor cells [0.03%]
小分子抑制剂混合物可促进原有肝祖细胞增殖
Qingjie Fu,Shunsuke Ohnishi,Goki Suda et al.
Qingjie Fu et al.
A recent study showed that a cocktail of three small molecules, Y-27632, A83-01, and CHIR99021 (YAC), converts mature hepatocytes (MHs) into proliferative bipotent cells that can be induced into MHs and cholangiocytes in rats. However, when...
Neutrophils as regulators of macrophage-induced inflammation in a setting of allogeneic bone marrow transplantation [0.03%]
中性粒细胞在allo-BMT后通过调节巨噬细胞介导的炎症反应调控移植物抗宿主病
Chao Hong,Hongyun Lu,Xiaohong Huang et al.
Chao Hong et al.
Clinical data reveal that patients with allogeneic hematopoietic stem cell transplantation (HSCT) are vulnerable to infection and prone to developing severe sepsis, which greatly compromises the success of transplantation, indicating a dysr...
Transcription factor-based direct conversion of human fibroblasts to functional astrocytes [0.03%]
基于转录因子的人成纤维细胞直接重编程为功能性的星形胶质细胞
Ella Quist,Francesco Trovato,Natalia Avaliani et al.
Ella Quist et al.
Astrocytes are emerging key players in neurological disorders. However, their role in disease etiology is poorly understood owing to inaccessibility of primary human astrocytes. Pluripotent stem cell-derived cells fail to mimic age and due ...
Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis [0.03%]
miR-139丢失导致的β-catenin上调参与了肌萎缩侧索硬化症中的运动神经元死亡
Sophie Hawkins,Seema C Namboori,Ammarah Tariq et al.
Sophie Hawkins et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of motor neurons (MNs). There are no effective treatments and patients usually die within 2-5 years of diagnosis. Emerging commonalities betw...
Aberrant nucleosome organization in mouse SCNT embryos revealed by ULI-MNase-seq [0.03%]
ULI-MNase-seq揭示小鼠体细胞克隆胚胎异常核小体组织
Lingyue Yang,Xiaocui Xu,Ruimin Xu et al.
Lingyue Yang et al.
Somatic cell nuclear transfer (SCNT) can reprogram terminally differentiated somatic cells into totipotent embryos, but with multiple defects. The nucleosome positioning, as an important epigenetic regulator for gene expression, is largely ...
Long-term survival in non-human primates of stem cell-derived, MHC-unmatched corneal epithelial cell sheets [0.03%]
基于多能干细胞、非组织相容性复合体匹配的角膜上皮细胞片在非人灵长类动物中的长期存活
Yu Yoshinaga,Takeshi Soma,Shohei Azuma et al.
Yu Yoshinaga et al.
When corneal epithelial stem cells residing in the corneal limbus become dysfunctional, called a limbal stem cell deficiency (LSCD), corneal transparency is decreased, causing severe vision loss. Transplantation of corneal epithelial cell s...
Conjunctival epithelial cells resist productive SARS-CoV-2 infection [0.03%]
结膜上皮细胞可抵抗SARS-CoV-2的感染发病
Robert M Jackson,Catherine F Hatton,Jarmila Stremenova Spegarova et al.
Robert M Jackson et al.
Conjunctival epithelial cells, which express viral-entry receptors angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine type 2 (TMPRSS2), constitute the largest exposed epithelium of the ocular surface tissue and may rep...