P450 oxidoreductase regulates barrier maturation by mediating retinoic acid metabolism in a model of the human BBB [0.03%]
细胞色素P450氧化还原酶通过介导类维生素A代谢调节人类血脑屏障模型的成熟屏障功能
Dor Zlotnik,Tatiana Rabinski,Aviv Halfon et al.
Dor Zlotnik et al.
The blood-brain barrier (BBB) selectively regulates the entry of molecules into the central nervous system (CNS). A crosstalk between brain microvascular endothelial cells (BMECs) and resident CNS cells promotes the acquisition of functiona...
The trophectoderm acts as a niche for the inner cell mass through C/EBPα-regulated IL-6 signaling [0.03%]
裂解细胞外信号调节激酶途径通过调控神经祖细胞生存促进局灶性脑缺血后的神经发生
Marcos Plana-Carmona,Gregoire Stik,Romain Bulteau et al.
Marcos Plana-Carmona et al.
IL-6 has been shown to be required for somatic cell reprogramming into induced pluripotent stem cells (iPSCs). However, how Il6 expression is regulated and whether it plays a role during embryo development remains unknown. Here, we describe...
Mettl14-driven senescence-associated secretory phenotype facilitates somatic cell reprogramming [0.03%]
Mettl14介导的衰老相关分泌表型促进体细胞重编程
Chenxiang Xi,Jiatong Sun,Xiaocui Xu et al.
Chenxiang Xi et al.
The METTL3-METTL14 complex, the "writer" of N6-methyladenosine (m6A), plays an important role in many biological processes. Previous studies have shown that Mettl3 overexpression can increase the level of m6A and promote somatic cell reprog...
Haifan Lin
Haifan Lin
Regulation of male germline transmission patterns by the Trp53-Cdkn1a pathway [0.03%]
Trp53-Cdkn1a通路调控雄性遗传方式模式
Mito Kanatsu-Shinohara,Honda Naoki,Takashi Tanaka et al.
Mito Kanatsu-Shinohara et al.
A small number of offspring are born from the numerous sperm generated from spermatogonial stem cells (SSCs). However, little is known regarding the rules and molecular mechanisms that govern germline transmission patterns. Here we report t...
Physiological calcium combined with electrical pacing accelerates maturation of human engineered heart tissue [0.03%]
生理钙内环境与电刺激联合使用可促进人类心脏组织工程化心肌成熟
Shi Shen,Lorenzo R Sewanan,Stephanie Shao et al.
Shi Shen et al.
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have wide potential application in basic research, drug discovery, and regenerative medicine, but functional maturation remains challenging. Here, we present a method wh...
The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis [0.03%]
EED-Gli3-Gli1调控轴的表观遗传状态控制胚胎皮层神经发生
Shuang-Feng Zhang,Shang-Kun Dai,Hong-Zhen Du et al.
Shuang-Feng Zhang et al.
Mutations in the embryonic ectoderm development (EED) cause Weaver syndrome, but whether and how EED affects embryonic brain development remains elusive. Here, we generated a mouse model in which Eed was deleted in the forebrain to investig...
Characterization of N-terminal RYR2 variants outside CPVT1 hotspot regions using patient iPSCs reveal pathogenesis and therapeutic potential [0.03%]
利用患者诱导多能干细胞表征CPVT1热点区域外的RYR2 N端变异体及其致病机制和治疗潜力
Marissa J Stutzman,C S John Kim,David J Tester et al.
Marissa J Stutzman et al.
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a cardiac channelopathy causing ventricular tachycardia following adrenergic stimulation. Pathogenic variants in RYR2-encoded ryanodine receptor 2 (RYR2) cause CPVT1 and cluste...
Exclusive generation of rat spermatozoa in sterile mice utilizing blastocyst complementation with pluripotent stem cells [0.03%]
利用全能干细胞进行囊胚补偿在无菌小鼠中产生大鼠精子细胞系
Joel Zvick,Monika Tarnowska-Sengül,Adhideb Ghosh et al.
Joel Zvick et al.
Blastocyst complementation denotes a technique that aims to generate organs, tissues, or cell types in animal chimeras via injection of pluripotent stem cells (PSCs) into genetically compromised blastocyst-stage embryos. Here, we report on ...
Dual inhibition of MAPK and PI3K/AKT pathways enhances maturation of human iPSC-derived cardiomyocytes [0.03%]
MAPK和PI3K/Akt途径的双重抑制可增强人多能干细胞源性心肌细胞的成熟效应
Bayardo I Garay,Sophie Givens,Phablo Abreu et al.
Bayardo I Garay et al.
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide great opportunities for mechanistic dissection of human cardiac pathophysiology; however, hiPSC-CMs remain immature relative to the adult heart. To identify nove...