Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes [0.03%]
埃博拉病毒感染诱导旁观者细胞中I型干扰素反应延迟及肝细胞系基因表达下调
Whitney A Scoon,Liliana Mancio-Silva,Ellen L Suder et al.
Whitney A Scoon et al.
Liver damage and an exacerbated inflammatory response are hallmarks of Ebola virus (EBOV) infection. Little is known about the intrinsic response to infection in human hepatocytes and their contribution to inflammation. Here, we present an ...
Loss of endosomal exchanger NHE6 leads to pathological changes in tau in human neurons [0.03%]
NHE6功能丧失导致人类神经元tau发生病理变化
Marty A Fernandez,Fatmata Bah,Li Ma et al.
Marty A Fernandez et al.
Disruption of endolysosomal and autophagy-lysosomal systems is increasingly implicated in neurodegeneration. Sodium-proton exchanger 6 (NHE6) contributes to the maintenance of proper endosomal pH, and loss-of function mutations in the X-lin...
Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived islets [0.03%]
全基因组CRISPR筛选识别出降低干细胞来源胰岛免疫排斥的遗传操作方法
Elad Sintov,Igor Nikolskiy,Victor Barrera et al.
Elad Sintov et al.
Human embryonic stem cells (hESCs) provide opportunities for cell replacement therapy of insulin-dependent diabetes. Therapeutic quantities of human stem cell-derived islets (SC-islets) can be produced by directed differentiation. However, ...
SETD4 cells contribute to brain development and maintain adult stem cell reservoir for neurogenesis [0.03%]
SETD4细胞参与脑发育并维持神经发生成人干细胞库
Sun-Li Cai,Yao-Shun Yang,Yan-Fu Ding et al.
Sun-Li Cai et al.
Cellular quiescence facilitates maintenance of neural stem cells (NSCs) and their subsequent regenerative functions in response to brain injury and aging. However, the specification and maintenance of NSCs in quiescence from embryo to adult...
Zhaohui Wang,Matteo Boretto,Rosemary Millen et al.
Zhaohui Wang et al.
In vitro tissue models hold great promise for modeling diseases and drug responses. Here, we used emulsion microfluidics to form micro-organospheres (MOSs), which are droplet-encapsulated miniature three-dimensional (3D) tissue models that ...
Human pluripotent stem cell-derived macrophages host Mycobacterium abscessus infection [0.03%]
人多能干细胞来源的巨噬细胞可发生坏死分枝杆菌感染
Shicheng Sun,Michael See,Hieu T Nim et al.
Shicheng Sun et al.
Human macrophages are a natural host of many mycobacterium species, including Mycobacterium abscessus (M. abscessus), an emerging pathogen affecting immunocompromised and cystic fibrosis patients with few available treatments. The search fo...
Novel intrinsic factor Yun maintains female germline stem cell fate through Thickveins [0.03%]
新颖的固有因子Yun通过Thickveins维持雌性生殖干细胞命运
Hang Zhao,Zhengran Li,Ruiyan Kong et al.
Hang Zhao et al.
Germline stem cells (GSCs) are critical for the reproduction of an organism. The self-renewal and differentiation of GSCs must be tightly controlled to avoid uncontrolled stem cell proliferation or premature stem cell differentiation. Howev...
Neuroblast migration along cellular substrates in the developing porcine brain [0.03%]
发育猪脑沿细胞基底膜迁移的神经母细胞簇集现象
Demisha D L Porter,Sara N Henry,Sadia Ahmed et al.
Demisha D L Porter et al.
In the past decade it has become evident that neuroblasts continue to supply the human cortex with interneurons via unique migratory streams shortly following birth. Owing to the size of the human brain, these newborn neurons must migrate l...
Development of a platform to investigate long-term potentiation in human iPSC-derived neuronal networks [0.03%]
一种研究人多能干细胞来源神经网络长时程增强的平台开发
Deborah Pré,Alexander T Wooten,Steven Biesmans et al.
Deborah Pré et al.
Impairment of long-term potentiation (LTP) is a common feature of many pre-clinical models of neurological disorders; however, studies in humans are limited by the inaccessibility of the brain. Human induced pluripotent stem cells (hiPSCs) ...
Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol [0.03%]
人tau突变在大脑类器官中诱导胆固醇渐进性失调
Stella M K Glasauer,Susan K Goderie,Jennifer N Rauch et al.
Stella M K Glasauer et al.
Mutations in the MAPT gene that encodes tau lead to frontotemporal dementia (FTD) with pathology evident in both cerebral neurons and glia. Human cerebral organoids (hCOs) from individuals harboring pathogenic tau mutations can reveal the e...