Molecular signature of human endometrial stem/progenitor cells at the single-cell level [0.03%]
单细胞水平上的人类子宫内膜干细胞/祖细胞分子特征
Harriet C Fitzgerald,Sally Mortlock,Caitlin E Filby et al.
Harriet C Fitzgerald et al.
Human endometrium sheds and regenerates each month during the menstrual cycle. N-cadherin+ (CDH2) glandular epithelial progenitors and SUSD2+ mesenchymal stem cells (MSCs) and their niches have been identified, but their signaling interacti...
Kei-Ichi Ishikawa,Takahiro Shiga,Takumi Hirose et al.
Kei-Ichi Ishikawa et al.
Cells derived from rejuvenated human induced pluripotent stem cells (hiPSCs) require extended culture periods to achieve functional maturation, and it remains difficult to recapitulate cellular senescence in these cells in vitro. This limit...
Pro-repair properties of a human embryonic stem cell-derived astrocyte cell therapy in demyelinating disorders [0.03%]
人胚胎干细胞来源的星形胶质细胞在脱髓鞘疾病中的促修复作用
Lihi Sofer Stepanov,Nina Fainstein,Marva Lachish et al.
Lihi Sofer Stepanov et al.
Remyelination failure in demyelinating diseases is driven by inefficient myelin debris clearance, impaired oligodendrocyte progenitor cell (OPC) differentiation into mature oligodendrocytes, and the absence of a sustained pro-repair inflamm...
HDAC4 regulates hASC osteogenesis and bone regeneration by mediating SMAD4 via histone acetylation [0.03%]
组蛋白乙酰化介导SMAD4在人脂肪源干细胞成骨及骨再生中的作用机制研究
Liyuan Yu,Kai Xia,Yijue Wang et al.
Liyuan Yu et al.
Craniofacial large bone defects possess limited self-repair capacity. This study identifies histone deacetylase 4 (HDAC4) as a key epigenetic repressor of osteogenesis in human adipose-derived stem cells. Inhibiting HDAC4, either geneticall...
Effects of voluntary exercise, diet, and selenium on hypothalamic adult neurogenesis [0.03%]
自愿运动、饮食和硒对下丘脑神经发生的影响
Sara K M Jörgensen,Rachel E Martin,Andrew Want et al.
Sara K M Jörgensen et al.
Hypothalamic adult neurogenesis is implicated in energy homeostasis; however, the impact of physical exercise, particularly under high-fat diet (HFD) conditions, on this process remains unclear. To address this, we subjected mice to short-t...
Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders [0.03%]
人多能干细胞向下丘脑神经元分化的可扩展性分化适用于代谢紊乱建模
Vukasin M Jovanovic,Narisu Narisu,Lori L Bonnycastle et al.
Vukasin M Jovanovic et al.
The hypothalamus, composed of multiple nuclei, is essential for maintaining the body's homeostasis. Within the mediobasal hypothalamus, the arcuate nucleus (ARC) contains key neuronal populations, including appetite-suppressing pro-opiomela...
Electron transport chain complex I and mitochondrial fusion regulate ROS for differentiation in Drosophila neural stem cells [0.03%]
线粒体融合通过调节果蝇神经干细胞分化的活性氧水平发挥作用
Rahul Kumar Verma,Atharva Bhingare,Dnyanesh Dubal et al.
Rahul Kumar Verma et al.
Mitochondrial fusion and electron transport chain complex I are each essential for differentiation in Drosophila neuroblasts, but the mechanism by which they interact to mediate differentiation is unknown. We found that complex I subunit de...
Rat cell-derived kidney generation via interspecies blastocyst complementation in an Osr1-KO mouse model [0.03%]
基于Osr1基因敲除小鼠的跨物种囊胚补偿产生 rat 细胞源肾脏
Shunsuke Yuri,Ayako Isotani
Shunsuke Yuri
Interspecies blastocyst complementation (BC) provides a promising approach to generate transplantable organs from pluripotent stem cells (PSCs). However, interspecies kidney generation has remained largely unsuccessful, particularly when us...
Chromosome X dosage modulates development of aneuploidy in genetically diverse mouse embryonic stem cells [0.03%]
染色体X的剂量调节遗传多样的小鼠胚胎干细胞中非整倍体的发展
Alexander Stanton,Selcan Aydin,Daniel A Skelly et al.
Alexander Stanton et al.
The genetic integrity of pluripotent stem cells (PSC) is critical to their applications in research and therapy, but it is compromised by frequent development of structural chromosome variants associated with malignancy. Many PSC lines exhi...
Hideyuki Okano
Hideyuki Okano