Transparency and ongoing communication with participants in brain organoid research: Consensus of an interdisciplinary working group [0.03%]
脑器官芯片研究中与受试者保持透明度和持续沟通：一个多学科工作组的共识
Betty Cohn,Megan Doerr,Pamela Feliciano et al.
Betty Cohn et al.
Stem cell-based models of the human brain benefit from biospecimens that can be used for a broad range of future research. But current regulations do not address the desire of research participants to remain engaged beyond initial biospecim...
Microgravity accelerates skeletal muscle degeneration: Functional and transcriptomic insights from an ISS muscle lab-on-chip model [0.03%]
微重力加速骨骼肌退行性变：来自国际空间站肌肉芯片模型的功能和转录组学见解
Maddalena Parafati,Zon Thwin,Legrand K Malany et al.
Maddalena Parafati et al.
Microgravity accelerates skeletal muscle degeneration, mimicking aspects of aging, yet its effects on muscle cell function remain underexplored. Using a muscle lab-on-chip model onboard the International Space Station (ISS), we examined 3D-...
Aged human serum induces vascular changes in an isogenic co-culture venule model [0.03%]
老化的人类血清通过同基因共培养静脉模型诱导血管变化
Tracy D Chung,Raleigh M Linville,Nan Zhao et al.
Tracy D Chung et al.
Vascular aging and dysfunction are significant contributors to age-related cardiovascular and neurodegenerative diseases. In particular, aging impacts small vessels, damaging vascular integrity leading to leakage events and inflammation, wh...
Graft-derived horizontal cells contribute to host-graft synapses in degenerated retinas after retinal organoid transplantation [0.03%]
Mikiya Watanabe,Takayuki Yamada,Hung-Ya Tu et al.
Mikiya Watanabe et al.
Stem cell-derived retinal organoid (RO) transplantation is a promising approach for treating retinal degenerative diseases such as retinitis pigmentosa. Photoreceptors (PRs) in RO sheets form synaptic connections with host bipolar cells (BC...
Elimination of tumorigenic pluripotent stem cells from their differentiated cell therapy products: An important step toward ensuring safe cell therapy [0.03%]
从其分化细胞治疗产品中消除肿瘤致病性多能干细胞：确保安全细胞治疗的重要步骤
Afsaneh Yazdani Movahed,Rana Bagheri,Pierre Savatier et al.
Afsaneh Yazdani Movahed et al.
Human pluripotent stem cells (hPSCs) are considered a promising tool for regenerative medicine due to their unique self-renewal and multi-lineage differentiation capabilities. Although over 100 clinical trials have employed hPSC-derived pro...
BMP, MEK, and WNT inhibition with NGN2 expression for rapid generation of hiPSC-derived neurons amenable to regional patterning [0.03%]
BMP、MEK和WNT抑制结合NGN2表达可促进hiPSC源性神经元的快速产生并有利于其区室化分型
Carina Habich,Alexandra Kowalski,Astrid Wachter et al.
Carina Habich et al.
Human induced pluripotent stem cells (hiPSCs) are a promising tool for studying neurological diseases and developing therapies for neurodegenerative diseases. Differentiation of hiPSCs into neurons can be achieved by dual SMAD inhibition (d...
Telmisartan is neuroprotective in a hiPSC-derived spinal microtissue model for C9orf72 ALS via inhibition of neuroinflammation [0.03%]
telmisartan通过抑制神经炎症在C9orf72型ALS的hiPSC衍生脊髓微组织模型中具有神经保护作用
Berkiye Sonustun,Björn F Vahsen,Mario Ledesma-Terrón et al.
Berkiye Sonustun et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron (MN) loss. The most common genetic cause, a hexanucleotide repeat expansion in C9orf72 (C9-ALS), disrupts microglial function...
Gustatory-neuron-supplied R-spondin-2 is required for taste bud replenishment [0.03%]
味觉芽补充所需的 gustducin神经供应的R-.spondin-2
Jiang Xu,Alan Moreira de Araujo,Ranhui Xi et al.
Jiang Xu et al.
Replenishment of taste cells in taste buds throughout life requires innervation. Recently, we provided evidence that R-spondin is sufficient to promote taste cell generation and restore taste buds in a nerve transection model. Yet, the nece...
Integrin β1 activity controls colony morphology during human pluripotent stem cell state transitions [0.03%]
人多能干细胞状态转换过程中整合素β1活性控制集落形态动力学
Maria E Taskinen,Nicolas Pasquier,Aki Stubb et al.
Maria E Taskinen et al.
Integrin β1-mediated adhesion is dispensable in early mouse embryogenesis (pre-implantation) but indispensable post-implantation, suggesting distinct roles for β1-integrin-mediated adhesions in the naive (pre-implantation) versus primed (...
APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids [0.03%]
APOE4影响皮层神经发育并改变人脑类器官网络形成
Karina K Meyer-Acosta,Eva Diaz-Guerra,Parul Varma et al.
Karina K Meyer-Acosta et al.
Apolipoprotein E4 (APOE4) is the leading genetic risk factor for Alzheimer's disease. While most studies examine the role of APOE4 in aging, APOE4 causes persistent changes in brain structure as early as infancy and is associated with alter...