BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming [0.03%]
含有BRD9的非典型BAF复合物维持体细胞转录组并作为重编程的人体屏障
Kenan Sevinç,Gülben Gürhan Sevinç,Ayşe Derya Cavga et al.
Kenan Sevinç et al.
Epigenetic reprogramming to pluripotency requires extensive remodeling of chromatin landscapes to silence existing cell-type-specific genes and activate pluripotency genes. ATP-dependent chromatin remodeling complexes are important regulato...
Virtual cells in a virtual microenvironment recapitulate early development-like patterns in human pluripotent stem cell colonies [0.03%]
虚拟微环境中虚拟细胞再现人类多能干细胞集落的早期发育样模式
Himanshu Kaul,Nicolas Werschler,Ross D Jones et al.
Himanshu Kaul et al.
The mechanism by which morphogenetic signals engage the regulatory networks responsible for early embryonic tissue patterning is incompletely understood. Here, we developed a minimal gene regulatory network (GRN) model of human pluripotent ...
Notch activation during early mesoderm induction modulates emergence of the T/NK cell lineage from human iPSCs [0.03%]
早期中胚层诱导期间Notch激活调节人类诱导多能干细胞中T/NK细胞系的出现
Dar Heinze,Seonmi Park,Andrew McCracken et al.
Dar Heinze et al.
A robust method of producing mature T cells from iPSCs is needed to realize their therapeutic potential. NOTCH1 is known to be required for the production of hematopoietic progenitor cells with T cell potential in vivo. Here we identify a c...
Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques [0.03%]
母体西式饮食重塑恒河猴胎儿造血干细胞和前体细胞的转录景观
Suhas Sureshchandra,Chi N Chan,Jacob J Robino et al.
Suhas Sureshchandra et al.
Maternal obesity adversely impacts the in utero metabolic environment, but its effect on fetal hematopoiesis remains incompletely understood. During late development, the fetal bone marrow (FBM) becomes the major site where macrophages and ...
Competency of iPSC-derived retinas in MHC-mismatched transplantation in non-human primates [0.03%]
人源iPSC视网膜在非人灵长类MHC不匹配移植中的免疫 Competence
Hirofumi Uyama,Hung-Ya Tu,Sunao Sugita et al.
Hirofumi Uyama et al.
Transplantation of embryonic/induced pluripotent stem cell-derived retina (ESC/iPSC-retina) restores host retinal ganglion cell light responses in end-stage retinal degeneration models with host-graft synapse formation. We studied the immun...
Patient-derived parathyroid organoids as a tracer and drug-screening application model [0.03%]
患者衍生的甲状旁腺器官样体作为踪迹和药物筛选应用模型
Milou E Noltes,Luc H J Sondorp,Laura Kracht et al.
Milou E Noltes et al.
Parathyroid diseases are characterized by dysregulation of calcium homeostasis and alterations in parathyroid hormone (PTH) excretion. The development of parathyroid-targeted treatment and imaging tracers could benefit from in vitro models....
Cell-autonomous lipid-handling defects in Stargardt iPSC-derived retinal pigment epithelium cells [0.03%]
视网膜色素上皮细胞自体脂质处理缺陷的星形胶质病诱导多能干细胞系
Mitra Farnoodian,Devika Bose,Vladimir Khristov et al.
Mitra Farnoodian et al.
Stargardt retinopathy is an inherited form of macular degeneration caused by mutations in gene ABCA4 and characterized by the accumulation of lipid-rich deposits in the retinal pigment epithelium (RPE), RPE atrophy, and photoreceptor cell d...
Stabilization of cell-cell adhesions prevents symmetry breaking and locks in pluripotency in 3D gastruloids [0.03%]
细胞间粘附的稳定可防止对称性破缺并使三维原肠胚中多能性的维持得以锁定
Federica Cermola,Filomena Amoroso,Federica Saracino et al.
Federica Cermola et al.
3D embryonic stem cell (ESC) aggregates self-organize into embryo-like structures named gastruloids that recapitulate the axial organization of post-implantation embryos. Crucial in this process is the symmetry-breaking event that leads to ...
Rag2-/- accelerates lipofuscin accumulation in the brain: Implications for human stem cell brain transplantation studies [0.03%]
Rag2-/-小鼠脑内脂褐质蓄积加速的表型及对人干细胞脑移植研究的影响
Mengmeng Jin,Mahabub Maraj Alam,Alice Y-C Liu et al.
Mengmeng Jin et al.
Immunodeficient mice are widely used in human stem cell transplantation research. Recombination activating gene 1 (Rag1) deletion results in immunodeficiency and leads to accelerated aging in zebrafish with increased cytosolic accumulation ...
Plasticity of ocular surface epithelia: Using a murine model of limbal stem cell deficiency to delineate metaplasia and transdifferentiation [0.03%]
眼表面上皮的可塑性：利用小鼠模型来阐明结膜干细胞缺乏时的化生和转分化现象
Mijeong Park,Richard Zhang,Elvis Pandzic et al.
Mijeong Park et al.
Maintaining corneal health and transparency are necessary pre-requisites for exquisite vision, a function ascribed to stem cells (SCs) nestled within the limbus. Perturbations to this site or depletion of its SCs results in limbal SC defici...