A set-theoretic definition of cell types with an algebraic structure on gene regulatory networks and application in annotation of RNA-seq data [0.03%]
基于基因调控网络代数结构的细胞类型集合论定义及在RNA序列数据注释中的应用
Yuji Okano,Yoshitaka Kase,Hideyuki Okano
Yuji Okano
The emergence of single-cell RNA sequencing (RNA-seq) has radically changed the observation of cellular diversity. Although annotations of RNA-seq data require preserved properties among cells of an identity, annotations using conventional ...
Patient-specific and gene-corrected induced pluripotent stem cell-derived endothelial cells elucidate single-cell phenotype of pulmonary veno-occlusive disease [0.03%]
患者特异性和基因校正的诱导多能干细胞来源的内皮细胞阐明了肺静脉闭塞性疾病的单细胞表型
Baihui Ma,Tianjiao Li,Wenke Li et al.
Baihui Ma et al.
Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension characterized by the preferential remodeling of the pulmonary venules. Hereditary PVOD is caused by biallelic variants of the EIF2AK4 gene. Three PVOD patients...
Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation [0.03%]
单细胞转录组学揭示了通过改进的hESC分化而来的正确发育动力学和高质量中脑细胞类型
Kaneyasu Nishimura,Shanzheng Yang,Ka Wai Lee et al.
Kaneyasu Nishimura et al.
Stem cell technologies provide new opportunities for modeling cells in health and disease and for regenerative medicine. In both cases, developmental knowledge and defining the molecular properties and quality of the cell types is essential...
Directly induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplantation in vivo [0.03%]
直接诱导的人视网膜神经节细胞模仿胎儿RGC，并在体内移植后具有神经营养作用
Ziming Luo,Kun-Che Chang,Suqian Wu et al.
Ziming Luo et al.
Retinal ganglion cell (RGC) replacement therapy could restore vision in glaucoma and other optic neuropathies. We developed a rapid protocol for directly induced RGC (iRGC) differentiation from human stem cells, leveraging overexpression of...
Laminin111-based defined culture promoting self-renewing human pluripotent stem cells with properties of the early post-implantation epiblast [0.03%]
基于层粘连蛋白111的确定培养促进具有早期着床后上胚层特性的自我更新人多能干细胞
Michal Gropp,Ithai Waldhorn,Yaniv Gil et al.
Michal Gropp et al.
In the mammalian embryo, a formative pluripotent phase is proposed to exist at the early post-implantation period, during the transition from the pre-implantation naive-to the post-implantation primed-epiblast. By recapitulating a laminin c...
Chitinase-like protein 3: A novel niche factor for mouse neural stem cells [0.03%]
壳多糖酶样蛋白3：小鼠神经干细胞的一种新型生态因子
Jun Namiki,Sayuri Suzuki,Shinsuke Shibata et al.
Jun Namiki et al.
The concept of a perivascular niche has been proposed for neural stem cells (NSCs). This study examined endothelial colony-forming cell (ECFC)-secreted proteins as potential niche factors for NSCs. Intraventricle infusion with ECFC-secreted...
Loss of mismatch repair promotes a direct selective advantage in human stem cells [0.03%]
错配修复的丢失促进了人类干细胞的直接选择优势
Kirby Madden-Hennessey,Dipika Gupta,Alexander A Radecki et al.
Kirby Madden-Hennessey et al.
Lynch syndrome (LS) is the most common hereditary form of colon cancer, resulting from a germline mutation in a DNA mismatch repair (MMR) gene. Loss of MMR in cells establishes a mutator phenotype, which may underlie its link to cancer. Acq...
Learning to listen: A complementary approach to informed consent for patients with visual impairments [0.03%]
学习倾听：视觉障碍患者知情同意的补充方法
Kayo Takashima,Takeshi Soma,Kaori Muto et al.
Kayo Takashima et al.
This forum describes an exploratory approach for assisting individuals with visual impairment during the informed consent (IC) process to participate in a cutting-edge trial. Our approach has been developed to focus on potential participant...
Satellite glia of the adult dorsal root ganglia harbor stem cells that yield glia under physiological conditions and neurons in response to injury [0.03%]
成体的背根神经节中的卫星胶质细胞包含在生理条件下生成胶质细胞而在受到损伤时生成神经元的干细胞。
Madlyne Maniglier,Marie Vidal,Corinne Bachelin et al.
Madlyne Maniglier et al.
The presence of putative stem/progenitor cells has been suggested in adult peripheral nervous system (PNS) tissue, including the dorsal root ganglion (DRG). To date, their identification and fate in pathophysiological conditions have not be...
The monoculture of cord-blood-derived CD34+ cells by an automated, membrane-based dynamic perfusion system with a novel cytokine cocktail [0.03%]
利用新型细胞因子鸡尾酒的自动化膜基动态灌流系统进行脐带血来源的CD34+细胞的单克隆培养
Mark Jones,Annie Cunningham,Nathan Frank et al.
Mark Jones et al.
Human leukocyte antigen (HLA)-matched cord blood (CB) transplantation is a procedure for the treatment of certain hematological malignancies, hemoglobinopathies, and autoimmune disorders. However, one of the challenges is to provide a suffi...