Increased oligodendrogenesis and myelination in the subventricular zone of aged mice and gray mouse lemurs [0.03%]
老年小鼠和灰鼠狐猴侧脑室区少突胶质细胞生成和髓鞘化增加
Lucile Butruille,Anthony Sébillot,Katia Ávila et al.
Lucile Butruille et al.
The adult rodent subventricular zone (SVZ) generates neural stem cells (NSCs) throughout life that migrate to the olfactory bulbs (OBs) and differentiate into olfactory interneurons. Few SVZ NSCs generate oligodendrocyte precursor cells (OP...
USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development [0.03%]
USP7失活可抑制APC突变型肠过度增殖和肿瘤发生
Laura Novellasdemunt,Anna Kucharska,Anna Baulies et al.
Laura Novellasdemunt et al.
Adenomatous polyposis coli (APC) mutation is the hallmark of colorectal cancer (CRC), resulting in constitutive WNT activation. Despite decades of research, targeting WNT signaling in cancer remains challenging due to its on-target toxicity...
Ribosomal proteins regulate 2-cell-stage transcriptome in mouse embryonic stem cells [0.03%]
核糖体蛋白调控小鼠胚胎干细胞中二细胞阶段转录组
Yao Yi,Yingying Zeng,Tsz Wing Sam et al.
Yao Yi et al.
A rare sub-population of mouse embryonic stem cells (mESCs), the 2-cell-like cell, is defined by the expression of MERVL and 2-cell-stage-specific transcript (2C transcript). Here, we report that the ribosomal proteins (RPs) RPL14, RPL18, a...
Unusual X chromosome inactivation maintenance in female alveolar type 2 cells is correlated with increased numbers of X-linked escape genes and sex-biased gene expression [0.03%]
女性II型肺泡细胞中不寻常的X染色体失活维持与X连锁基因逃逸数量增加及性别偏向基因表达相关
Isabel Sierra,Sarah Pyfrom,Aaron Weiner et al.
Isabel Sierra et al.
Sex differences exist for many lung pathologies, including COVID-19 and pulmonary fibrosis, but the mechanistic basis for this remains unclear. Alveolar type 2 cells (AT2s), which play a key role in alveolar lung regeneration, express the X...
ISSCR Education Committee syllabus and learning guide for enhancing stem cell literacy [0.03%]
增强干细胞知识的ISSCR教育委员会教学大纲和学习指南
Julie R Perlin,William J Anderson,Sina Bartfeld et al.
Julie R Perlin et al.
The rapidly evolving stem cell field puts much stress on developing educational resources. The ISSCR Education Committee has created a flexible stem cell syllabus rooted in core concepts to facilitate stem cell literacy. The free syllabus w...
Generation of anti-GD2 CAR macrophages from human pluripotent stem cells for cancer immunotherapies [0.03%]
用于癌症免疫治疗的由人类多能干细胞生成的抗GD2嵌合抗原受体巨噬细胞
Jue Zhang,Sarah Webster,Bret Duffin et al.
Jue Zhang et al.
Macrophages armed with chimeric antigen receptors (CARs) provide a potent new option for treating solid tumors. However, genetic engineering and scalable production of somatic macrophages remains significant challenges. Here, we used CRISPR...
Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition [0.03%]
从多能性向全能性状转换过程中H3K9me3的重塑
Hu Li,Jiatong Sun,Yu Dong et al.
Hu Li et al.
Multiple chromatin modifiers associated with H3K9me3 play important roles in the transition from embryonic stem cells to 2-cell (2C)-like cells. However, it remains elusive how H3K9me3 is remodeled and its association with totipotency. Here...
A pluripotent developmental state confers a low fidelity of chromosome segregation [0.03%]
多能性的发展状态赋予了染色体分离的低保真度
Chenhui Deng,Amanda Ya,Duane A Compton et al.
Chenhui Deng et al.
During in vitro propagation, human pluripotent stem cells (hPSCs) frequently become aneuploid with incorrect chromosome numbers due to mitotic chromosome segregation errors. Yet, it is not understood why hPSCs exhibit a low mitotic fidelity...
John F Ouyang,Sonia Chothani,Owen J L Rackham
John F Ouyang
Our ability to understand and control stem cell biology is being augmented by developments on two fronts, our ability to collect more data describing cell state and our capability to comprehend these data using deep learning models. Here we...
Rag2-/- accelerates lipofuscin accumulation in the brain: Implications for human stem cell brain transplantation studies [0.03%]
Rag2-/- 加速大脑中类脂褐质的积累：对人类干细胞脑移植研究的意义
Mengmeng Jin,Mahabub Maraj Alam,Alice Y-C Liu et al.
Mengmeng Jin et al.
Published Erratum
Stem cell reports. 2023 Jan 10;18(1):413-415. DOI:10.1016/j.stemcr.2022.11.023 2023