In silico discovery of small molecules for efficient stem cell differentiation into definitive endoderm [0.03%]
高效诱导干细胞向 definite endoderm分化的药物的in silico研究
Gherman Novakovsky,Shugo Sasaki,Oriol Fornes et al.
Gherman Novakovsky et al.
Improving methods for human embryonic stem cell differentiation represents a challenge in modern regenerative medicine research. Using drug repurposing approaches, we discover small molecules that regulate the formation of definitive endode...
The isochromosome 20q abnormality of pluripotent cells interrupts germ layer differentiation [0.03%]
多能细胞中的20q等臂染色体异常中断了胚层分化
Loriana Vitillo,Fabiha Anjum,Zoe Hewitt et al.
Loriana Vitillo et al.
Chromosome 20 abnormalities are some of the most frequent genomic changes acquired by human pluripotent stem cell (hPSC) cultures worldwide. Yet their effects on differentiation remain largely unexplored. We investigated a recurrent abnorma...
Meaningful steps toward equity, diversity, and inclusion: A call to action [0.03%]
迈向平等、包容和多样性的有意义的一步——行动呼吁
Saliha Moore,Eugenia Piddini
Saliha Moore
EDI allies congregated to highlight initiatives intended to address barriers to research opportunities and support that could promote recruitment and retention of diverse talent, encourage collaborative research, improve community engagemen...
BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and oligodendrogenesis in Alzheimer's patients' iPSCs in senescence-related conditions [0.03%]
BMP4-SMAD1/5/9-RUNX2信号通路活化抑制阿尔茨海默病患者诱导多能干细胞在衰老相关条件下向神经元和少突胶质细胞分化
Daiki Nakatsu,Rina Kunishige,Yuki Taguchi et al.
Daiki Nakatsu et al.
In addition to increasing β-amyloid plaque deposition and tau tangle formation, inhibition of neurogenesis has recently been observed in Alzheimer's disease (AD). This study generated a cellular model that recapitulated neurogenesis defect...
Excitotoxic glutamate levels drive spinal cord ependymal stem cell proliferation and fate specification through CP-AMPAR signaling [0.03%]
天冬氨酸水平通过CP-AMPA受体信号驱动脊髓室管膜干细胞的增殖和分化方向
Laureen D Hachem,James Hong,Alexander Velumian et al.
Laureen D Hachem et al.
The adult spinal cord contains a population of ependymal-derived neural stem/progenitor cells (epNSPCs) that are normally quiescent, but are activated to proliferate, differentiate, and migrate after spinal cord injury. The mechanisms that ...
Generation of functional human T cell development in NOD/SCID/IL2rγnull humanized mice without using fetal tissue: Application as a model of HIV infection and persistence [0.03%]
无需使用胎儿组织在NOD/SCID/IL2rγnull人源化小鼠中生成功能性的人T细胞发育：作为HIV感染和持续存在的模型的应用
Chloé Colas,Olga Volodina,Kathie Béland et al.
Chloé Colas et al.
Humanization of mice with functional T cells currently relies on co-implantation of hematopoietic stem cells from fetal liver and autologous fetal thymic tissue (so-called BLT mouse model). Here, we show that NOD/SCID/IL2rγnull mice humani...
Xiongzhuo Tang,Na Liu,Hongying Qi et al.
Xiongzhuo Tang et al.
PIWI genes are well known for their germline but not somatic functions. Here, we report the function of the Drosophila piwi gene in the adult gut, where intestinal stem cells (ISCs) produce enteroendocrine cells and enteroblasts that genera...
Critical considerations for public engagement in stem cell-related research [0.03%]
公众参与干细胞研究中的关键问题考虑因素
Jeremy Sugarman,Amander Clark,James Fishkin et al.
Jeremy Sugarman et al.
Public engagement is increasingly recognized as being integral to basic and translational research. Public engagement involves effective communication about research along with the mutual exchange of views and opinions among a wide variety ...
A phenotypic screen of Marfan syndrome iPSC-derived vascular smooth muscle cells uncovers GSK3β as a new target [0.03%]
马凡氏综合症iPSC衍生血管平滑肌细胞的表型筛查发现GSK3β为新靶点
Hongorzul Davaapil,Madeline McNamara,Alessandra Granata et al.
Hongorzul Davaapil et al.
Marfan syndrome (MFS) is a rare connective tissue disorder caused by mutations in FBN1. Patients with MFS notably suffer from aortic aneurysm and dissection. Despite considerable effort, animal models have proven to be poorly predictive for...
Human spinal GABA neurons survive and mature in the injured nonhuman primate spinal cord [0.03%]
人脊髓GABA神经元在受伤的非人灵长类动物脊髓中存活并成熟
Xiaolong Zheng,Bo Zhu,Jiang Xu et al.
Xiaolong Zheng et al.
Spinal cord injury (SCI) leads to permanent neural dysfunction without effective therapies. We previously showed that human pluripotent stem cell (hPSC)-derived spinal GABA neurons can alleviate spasticity and promote locomotion in rats aft...