Resident mesenchymal progenitor cells require autocrine IGF-I in homeostatic and regenerating skeletal muscle [0.03%]
静止状态和再生骨骼肌中的居民间充质前体细胞需要自分泌IGF-I
Yangyi E Luo,Zoe Abe-Teh,Tarek Y Alsaghir et al.
Yangyi E Luo et al.
Fibro-adipogenic progenitors (FAPs) are muscle-resident mesenchymal stromal cells essential for homeostasis and regeneration but can produce fibrosis or intramuscular fat in pathological conditions. Insulin-like growth factor-I (IGF-I) regu...
Early replication fragile sites are associated with cancer-related CNVs and SNVs in human embryonic stem cells [0.03%]
人类胚胎干细胞中的早期复制不稳定的脆弱位点与癌症相关的拷贝数变异和单核苷酸变异有关
Yu-Ping Dong,Menglin Qiu,Haoyu Tang et al.
Yu-Ping Dong et al.
Long-term culture of human embryonic stem cells (hESCs) often induces chromosomal abnormalities, which limits their clinical use. However, the underlying mechanisms are unclear. Early replication fragile sites (ERFSs) are genomic loci susce...
Adipose precursor cell-derived clusterin promotes homeostasis in subcutaneous adipose tissue [0.03%]
前脂肪细胞源性簇素促进皮下脂肪组织稳态
Zong Chen,Zhiyou Chen,Jiuzuo Huang et al.
Zong Chen et al.
Adipose precursor cells (APCs), present within the stromal vascular fraction (SVF) of adipose tissue, play an important role in adipose biology. However, its regulatory functions in adipogenesis and tissue homeostasis remain incompletely ch...
Single-cell multiomic approaches define a gradual, spatially regulated epigenetic and transcriptional transition from embryonic to adult neural stem cells [0.03%]
单细胞多组学方法确定了从胚胎神经干细胞到成人神经干细胞的表观遗传和转录渐进过渡及其空间调节
Beatrix S Wang,Konstantina Karamboulas,Nareh Tahmasian et al.
Beatrix S Wang et al.
Here, we ask how adult neural stem cells (NSCs) arise developmentally, focusing on murine cortical precursors that generate excitatory neurons embryonically and interneurons and glial cells postnatally. Using complementary single-cell spati...
Targeting CCDC90B restores intestinal stem cell function under hyperuricemic stress [0.03%]
靶向CCDC90B可在高尿酸应激下恢复肠道干细胞功能
Xiuying Peng,Moxuan Li,Kaixuan Zeng et al.
Xiuying Peng et al.
Hyperuricemia (HUA) affects diverse biological processes and signaling pathways across multiple organ systems; however, its impact on the intestine remains poorly understood. Here, we show that HUA disrupts intestinal barrier function prima...
Aging of hematopoietic stem cells is inconsequential to progenitor cell function [0.03%]
造血干细胞衰老不影响祖细胞功能
Jenna Myers,Atesh K Worthington,Donna M Poscablo et al.
Jenna Myers et al.
Aging of the hematopoietic system has profound consequences for organismal health and longevity, attributed to the well-characterized functional aging of hematopoietic stem cells (HSCs). Here, we tested whether progenitor cells may demonstr...
KDM8 acts as a co-regulator of transcription factor SOX2 for promoting cell pluripotency [0.03%]
KDM8作为转录因子SOX2促进细胞多能性的共调节因子
Songqin Yang,Zhikai Ye,Lu Lin et al.
Songqin Yang et al.
iPSCs have drawn significant attention for their biomedical potential, yet reprogramming remains inefficient and the underlying mechanisms are incompletely defined. KDM8, a histone demethylase, is known to play critical roles in processes s...
WNT signaling in human pluripotent stem cells promotes HDAC2-dependent epigenetic programs and development of retinoic acid-responsive mesoderm [0.03%]
Wnt信号通过组蛋白去乙酰化酶HDAC2促进人类多能干细胞的表观遗传重编程和视黄酸反应外胚层的发育
Bao Q Thai,Elizabeth J Sargent,Stephanie A Luff et al.
Bao Q Thai et al.
Human pluripotent stem cells (hPSCs) can be used as a scalable source of lymphocytes for adoptive cell therapies, contingent on the robust generation of definitive hematopoietic intermediates. Early WNT activation with CHIR99021 during meso...
Cloud-connected pluripotent stem cell platform enhances scientific identity in underrepresented students [0.03%]
云端连接的多能干细胞平台增强了少数族裔学生的科学认同感
Samira Vera-Choqqueccota,Drew Ehrlich,Vladimir Luna-Gomez et al.
Samira Vera-Choqqueccota et al.
Stem cell research offers unique opportunities for authentic scientific engagement, yet infrastructure requirements have confined participation to elite institutions, perpetuating workforce disparities. We developed an integrated framework ...
Multiome-based identification of molecular markers for prospective identification of platelet-biased HSCs [0.03%]
基于多组学的分子标志物鉴定用于前瞻识别血小板偏好的造血干细胞
Bowen Zhang,Yiran Meng,Esther Rodríguez Correa et al.
Bowen Zhang et al.
Platelet-biased hematopoietic stem cells (PLT-HSCs) play key roles in normal physiology, aging, and blood cancer. However, currently, no markers allow their accurate identification or prospective isolation. We here combine single-mouse hema...