Single-cell transcriptomics reveal individual and cooperative effects of trisomy 21 and GATA1s on hematopoiesis [0.03%]
单细胞转录组揭示了21三体和GATA1s对造血个体及协同效应
Kaoru Takasaki,Eric K Wafula,Jian Meng Fan et al.
Kaoru Takasaki et al.
Trisomy 21 (T21) is associated with baseline erythrocytosis, thrombocytopenia, neutrophilia, transient abnormal myelopoiesis (TAM), and myeloid leukemia of Down syndrome (ML-DS). TAM and ML-DS blasts harbor mutations in GATA1, resulting in ...
Ins and outs of HSCs and VEGF-induced vascular remodeling: Toward improved HSC mobilization and engraftment [0.03%]
造血干细胞和VEGF诱导的血管重塑的内部和外部因素：提高造血干细胞动员和植入的新方法
Madeline J Caduc,Simón Méndez-Ferrer
Madeline J Caduc
Disruption of normal stem cell function and transmission of myelodysplastic syndrome by self-renewal of committed myeloid lineage cells [0.03%]
髓系细胞自我更新干扰正常干细胞功能并向后代传递骨髓增生异常综合征
Yang Jo Chung,Ryan Bertoli,Dengchao Cao et al.
Yang Jo Chung et al.
The ineffective hematopoiesis of myelodysplastic syndrome (MDS) suggests that hematopoietic stem and progenitor cells (HSPCs) are defective. Here, we demonstrate that NUP98::HOXD13 (NHD13) MDS mice have significantly decreased functional HS...
Progenitor neighborhoods function as transient niches to sustain olfactory neurogenesis [0.03%]
祖细胞巢域作为瞬时生境维持嗅觉神经发生的类干细胞区
Sriivatsan G Rajan,Lynne M Nacke,Joseph N Lombardo et al.
Sriivatsan G Rajan et al.
Olfactory neurogenesis occurs throughout the lives of vertebrates, including in humans, and relies on the continuous differentiation and integration of neurons into a complex network. How progenitor cells convert fluctuations in cell-cell s...
Developmental cues from epicardial cells simultaneously promote cardiomyocyte proliferation and electrochemical maturation [0.03%]
心外膜细胞发出的发育信号可同时促进心肌细胞增殖和电化学成熟
Sophie E Givens,Abygail A Andebrhan,Ruchen Wang et al.
Sophie E Givens et al.
Accumulating evidence indicates that maturation limits cardiomyocyte proliferation. We expand on that theory by co-culturing human induced pluripotent stem cell (hiPSC)-cardiomyocytes (CM) with epicardial cells (EPCs) and epicardial-derived...
Georgia Lokka,Anna Chantzara,Zoi Lygerou et al.
Georgia Lokka et al.
Multiciliated ependymal and neural stem cells are key cell populations of the subventricular zone. Recent findings revealed that at least a subpopulation of radial glial cells during embryogenesis can be bipotent and produce both neural ste...
DDR1 regulates RUNX1-CBFβ to control breast stem cell differentiation [0.03%]
DDR1通过调节RUNX1-CBFβ控制乳腺干细胞分化
Colin Trepicchio,Gat Rauner,Nicole Traugh et al.
Colin Trepicchio et al.
Understanding epithelial stem cell differentiation and morphogenesis during breast tissue development is essential, as disruption in these processes underlie breast cancer formation. We used a next-generation single-cell-derived organoid mo...
Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource [0.03%]
利用人类诱导多能干细胞模拟高风险和低风险常见阿尔茨海默病：大规模研究资源
Emily Maguire,Jincy Winston,Sarah H Ellwood et al.
Emily Maguire et al.
Common forms of Alzheimer's disease (AD) are complex and polygenic. We have created a research resource that seeks to capture the extremes of polygenic risk in a collection of human induced pluripotent stem cell (iPSC) lines from over 100 d...
CD37 regulates the self-renewal of leukemic stem cells via integrin-mediated signaling in acute myeloid leukemia [0.03%]
CD37通过整合素介导的信号转导调节急性髓系白血病白血病干细胞的自我更新
Jinyuan Lu,Lixin Lv,Xiaoxue Tian et al.
Jinyuan Lu et al.
Published Erratum
Stem cell reports. 2025 Jun 28:102573. DOI:10.1016/j.stemcr.2025.102573 2025
Vascular endothelial growth factor-induced vascular permeability results in drastic and reversible hematopoietic stem cell mobilization [0.03%]
血管内皮生长因子诱导的血管通透性可导致剧烈而可逆的造血干细胞动员
Stephanie Smith-Berdan,Mark Landon,Bryan Petkus et al.
Stephanie Smith-Berdan et al.
Lifelong hematopoiesis as well as hematopoietic transplantation therapies is dependent on the ability of hematopoietic stem cells (HSCs) to effectively traffic across the bone marrow (BM) endothelium. Mounting evidence suggests that modulat...