WNT7A suppresses adipogenesis of skeletal muscle mesenchymal stem cells and fatty infiltration through the alternative Wnt-Rho-YAP/TAZ signaling axis [0.03%]
WNt7a通过替代的Wnt-Rho-YAP / TAZ信号轴抑制骨骼肌间充质干细胞的脂肪生成和脂肪浸润
Chengcheng Fu,Britney Chin-Young,GaYoung Park et al.
Chengcheng Fu et al.
Intramuscular fatty infiltration in muscle injuries and diseases, caused by aberrant adipogenesis of fibro-adipogenic progenitors, negatively impacts function. Intramuscular delivery of wingless-type MMTV integration site family 7a (WNT7A) ...
A miR-124-mediated post-transcriptional mechanism controlling the cell fate switch of astrocytes to induced neurons [0.03%]
一种miR-124介导的星形胶质细胞转分化为诱导神经元的新机制研究
Elsa Papadimitriou,Paraskevi N Koutsoudaki,Irini Thanou et al.
Elsa Papadimitriou et al.
The microRNA (miRNA) miR-124 has been employed supplementary to neurogenic transcription factors (TFs) and other miRNAs to enhance direct neurogenic conversion. The aim of this study was to investigate whether miR-124 is sufficient to drive...
Re-generation of cytotoxic γδT cells with distinctive signatures from human γδT-derived iPSCs [0.03%]
人γδT细胞衍生的诱导多能干细胞系再生具有不同特征的细胞毒性γδT细胞
Nobuyuki Murai,Michiyo Koyanagi-Aoi,Hiroto Terashi et al.
Nobuyuki Murai et al.
For a long time, ex vivo-expanded peripheral-blood-derived γδT cell (PBγδT)-based immunotherapy has been attractive, and clinical trials have been undertaken. However, the difficulty in expanding cytotoxic γδT cells to an adequate num...
Allogeneic offspring produced by induction of PD-L1 in spermatogonial stem cells via self-renewal stimulation [0.03%]
通过自我更新刺激诱导PD-L1在精子干细胞中的表达产生同种异体后代
Takashi Shinohara,Takuya Yamamoto,Hiroko Morimoto et al.
Takashi Shinohara et al.
The testis is an immune-privileged organ. It is considered that the testis somatic microenvironment is responsible for immune suppression. However, immunological properties of spermatogonial stem cells (SSCs) have remained unknown. Here, we...
Generation of functional thymic organoids from human pluripotent stem cells [0.03%]
人多能干细胞源功能性胸腺类器官的构建
Stephan A Ramos,Lucas H Armitage,John J Morton et al.
Stephan A Ramos et al.
The thymus is critical for the establishment of a functional and self-tolerant adaptive immune system but involutes with age, resulting in reduced naive T cell output. Generation of a functional human thymus from human pluripotent stem cell...
Viral delivery of L1CAM promotes axonal extensions by embryonic cerebral grafts in mouse brain [0.03%]
病毒传递L1CAM促进小鼠脑内胚胎大脑移植物的轴突生长
Ryosuke Tsuchimochi,Keitaro Yamagami,Naoko Kubo et al.
Ryosuke Tsuchimochi et al.
Cell replacement therapy is expected as a new and more radical treatment against brain damage. We previously reported that transplanted human cerebral organoids extend their axons along the corticospinal tract in rodent brains. The axons re...
Generation of hypothalamic neural stem cell-like cells in vitro from human pluripotent stem cells [0.03%]
体外通过多能干细胞生成下丘脑神经干细胞样细胞
Tsutomu Miwata,Hidetaka Suga,Yohei Kawaguchi et al.
Tsutomu Miwata et al.
When damaged, restoring the function of the hypothalamus is currently impossible. It is unclear whether neural stem cells exist in the hypothalamus. Studies have reported that adult rodent tanycytes around the third ventricle function as hy...
Mechanical strain treatment improves nuclear transfer reprogramming efficiency by enhancing chromatin accessibility [0.03%]
机械牵张提高体细胞核移植效率通过增强染色质可接近性实现
Yujie Chen,Ruimin Xu,Shuang Zhou et al.
Yujie Chen et al.
Cellular mechanical properties are considered to be important factors affecting cell fate transitions, but the links between cellular mechanical properties and transition efficiency and chromatin structure remain elusive. Here, we predicted...
Survey of Japanese researchers and the public regarding the culture of human embryos in vitro beyond 14 days [0.03%]
关于体外受精胚胎14天后的日本研究人员及公众调查报告
Hideki Yui,Kaori Muto,Yoshimi Yashiro et al.
Hideki Yui et al.
The International Society for Stem Cell Research (ISSCR) has eliminated its prohibition on research involving the culturing of human embryos beyond 14 days within the updated 2021 guidelines. We conducted a survey of Japanese researchers wo...
Long noncoding RNA Lnc530 localizes on R-loops and regulates R-loop formation and genomic stability in mouse embryonic stem cells [0.03%]
长非编码RNA Lnc530定位于R-环并在小鼠胚胎干细胞中调控R-环的形成和基因组稳定性
Daohua Gong,Lin Wang,Hu Zhou et al.
Daohua Gong et al.
Embryonic stem cells (ESCs) are superior to differentiated cells to maintain genome stability, but the underlying mechanisms remain largely elusive. R-loops are constantly formed during transcription and are inducers of DNA damage if not re...