Mesenchymal loss of p53 alters stem cell capacity and models human soft tissue sarcoma traits [0.03%]
间充质p53丢失改变干细胞能力并模拟人类软组织肉瘤特征
Yuriko Sorimachi,Hiroshi Kobayashi,Yusuke Shiozawa et al.
Yuriko Sorimachi et al.
Soft tissue sarcomas (STSs) are a heterogeneous group of tumors that originate from mesenchymal cells. p53 is frequently mutated in human STS. In this study, we found that the loss of p53 in mesenchymal stem cells (MSCs) mainly causes adult...
Lovastatin promotes the self-renewal of murine and primate spermatogonial stem cells [0.03%]
洛伐他汀促进小鼠和灵长类精子干细胞的自我更新
Chaohui Li,Zhaokai Yao,Linzi Ma et al.
Chaohui Li et al.
The spermatogonial stem cell (SSC) niche is critical for SSC maintenance and subsequent spermatogenesis. Numerous reproductive hazards impair the SSC niche, thereby resulting in aberrant SSC self-renewal and male infertility. However, promi...
Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells [0.03%]
限制卡路里摄取通过自体调节休眠干细胞中的mTORC1来调控肠上皮再生
Maryam Yousefi,Angela Nakauka-Ddamba,Corbett T Berry et al.
Maryam Yousefi et al.
Published Erratum
Stem cell reports. 2023 Apr 11;18(4):1048. DOI:10.1016/j.stemcr.2023.03.010 2023
Scalable generation of sensory neurons from human pluripotent stem cells [0.03%]
人多能干细胞感觉神经元的可扩展分化体系
Tao Deng,Vukasin M Jovanovic,Carlos A Tristan et al.
Tao Deng et al.
Development of new non-addictive analgesics requires advanced strategies to differentiate human pluripotent stem cells (hPSCs) into relevant cell types. Following principles of developmental biology and translational applicability, here we ...
Segregation of the stemness program from the proliferation program in intestinal stem cells [0.03%]
肠干细胞中将自我更新程序与增殖程序相分离
Yuan Liu,Meimei Huang,Xiaodan Wang et al.
Yuan Liu et al.
Stem cells can undergo continuous self-renewal and meanwhile retain the stemness capability to differentiate to mature functional cells. However, it is unclear whether the proliferation property can be segregated from the stemness in stem c...
Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells [0.03%]
优化的全基因组CRISPR干扰筛选鉴定出人类诱导多能干细胞中ARID1A依赖型生长调节因子
Sunay Usluer,Pille Hallast,Luca Crepaldi et al.
Sunay Usluer et al.
Perturbing expression is a powerful way to understand the role of individual genes, but can be challenging in important models. CRISPR-Cas screens in human induced pluripotent stem cells (iPSCs) are of limited efficiency due to DNA break-in...
History and current status of clinical studies using human pluripotent stem cells [0.03%]
人多能干细胞临床研究应用的历史与现状
Sabine Kobold,Nils Bultjer,Glyn Stacey et al.
Sabine Kobold et al.
The Human Pluripotent Stem Cell Registry established a database of clinical studies using human pluripotent stem cells (PSCs) as starting material for cell therapies. Since 2018, we have observed a switch toward human induced pluripotent st...
Public perceptions and expectations: Disentangling the hope and hype of organoid research [0.03%]
公众的认识与期望：解开类器官研究中希望与炒作的区别
Tine Ravn,Mads P Sørensen,Emma Capulli et al.
Tine Ravn et al.
Organoid technologies are rapidly advancing and hold great potential and hope for disease modeling and clinical translational research. Still, they raise a number of complex, ethical questions regarding their current and future use. Patient...
Differentiation of uniparental human embryonic stem cells into granulosa cells reveals a paternal contribution to gonadal development [0.03%]
单亲人类胚胎干细胞向颗粒细胞分化表明父系对生殖腺发育的贡献
Gal Keshet,Shiran Bar,Roni Sarel-Gallily et al.
Gal Keshet et al.
Genomic imprinting underlies the mammalian requirement for sexual reproduction. Nonetheless, the relative contribution of the two parental genomes during human development is not fully understood. Specifically, a fascinating question is whe...
Epicardially secreted fibronectin drives cardiomyocyte maturation in 3D-engineered heart tissues [0.03%]
epicardium分泌的fibronectin促进3D心脏工程组织中心肌细胞成熟
Lay Ping Ong,Johannes Bargehr,Vincent R Knight-Schrijver et al.
Lay Ping Ong et al.
Ischemic heart failure is due to irreversible loss of cardiomyocytes. Preclinical studies showed that human pluripotent stem cell (hPSC)-derived cardiomyocytes could remuscularize infarcted hearts and improve cardiac function. However, thes...