Cardiac myofibrillogenesis is spatiotemporally modulated by the molecular chaperone UNC45B [0.03%]
分子伴侣UNC45B调控心脏肌节时空模式化生成
Serena Huei-An Lu,Yi-Hsuan Wu,Liang-Yu Su et al.
Serena Huei-An Lu et al.
Sarcomeres are fundamental to cardiac muscle contraction. Their impairment can elicit cardiomyopathies, leading causes of death worldwide. However, the molecular mechanism underlying sarcomere assembly remains obscure. We used human embryon...
Generation and purification of ACTH-secreting hPSC-derived pituitary cells for effective transplantation [0.03%]
生成并提纯用于有效移植的分泌ACTH的hPSC衍生垂体细胞
Shiori Taga,Hidetaka Suga,Tokushige Nakano et al.
Shiori Taga et al.
Pituitary organoids are promising graft sources for transplantation in treatment of hypopituitarism. Building on development of self-organizing culture to generate pituitary-hypothalamic organoids (PHOs) using human pluripotent stem cells (...
Oligodendrocytes in human induced pluripotent stem cell-derived cortical grafts remyelinate adult rat and human cortical neurons [0.03%]
人诱导多能干细胞来源的皮层组织片中的少突胶质细胞可对大鼠和人的皮层神经元进行再髓鞘化
Raquel Martinez-Curiel,Linda Jansson,Oleg Tsupykov et al.
Raquel Martinez-Curiel et al.
Neuronal loss and axonal demyelination underlie long-term functional impairments in patients affected by brain disorders such as ischemic stroke. Stem cell-based approaches reconstructing and remyelinating brain neural circuitry, leading to...
Embryonic stem cell ERK, AKT, plus STAT3 response dynamics combinatorics are heterogeneous but NANOG state independent [0.03%]
胚胎干细胞ERK、AKT和STAT3信号反应动力学组合是不同的，但不受NANOG状态的影响
Andreas Reimann,Tobias Kull,Weijia Wang et al.
Andreas Reimann et al.
Signaling is central in cell fate regulation, and relevant information is encoded in its activity over time (i.e., dynamics). However, simultaneous dynamics quantification of several pathways in single mammalian stem cells has not yet been ...
Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells [0.03%]
雄激素信号通过经典Wnt信号通路调控前列腺基底干细胞的机制研究
Corrigan Horton,Yueli Liu,Jiawen Wang et al.
Corrigan Horton et al.
Both the canonical Wnt and androgen receptor (AR) signaling pathways are important for prostate organogenesis and homeostasis. How they crosstalk to regulate prostate stem cell behaviors remains unclear. Here, we show in lineage-tracing mou...
Regulation of neural stem cell differentiation and brain development by MGAT5-mediated N-glycosylation [0.03%]
MGAT5介导的N-连接糖基化调节神经干细胞分化和脑发育
Andrew R Yale,Estelle Kim,Brenda Gutierrez et al.
Andrew R Yale et al.
Undifferentiated neural stem and progenitor cells (NSPCs) encounter extracellular signals that bind plasma membrane proteins and influence differentiation. Membrane proteins are regulated by N-linked glycosylation, making it possible that g...
Difficulties in ensuring review quality performed by committees under the Act on the Safety of Regenerative Medicine in Japan [0.03%]
日本再生医疗安全法下的审查委员会制度确保审查质量的课题分析
Tsunakuni Ikka,Misao Fujita,Taichi Hatta et al.
Tsunakuni Ikka et al.
Published Erratum
Stem cell reports. 2023 May 9;18(5):1247. DOI:10.1016/j.stemcr.2023.04.006 2023
BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and oligodendrogenesis in Alzheimer's patients' iPSCs in senescence-related conditions [0.03%]
BMP4-SMAD1/5/9-RUNX2信号通路活化抑制阿尔茨海默病患者的诱导多能干细胞在衰老相关条件下向神经元和少突胶质细胞分化
Daiki Nakatsu,Rina Kunishige,Yuki Taguchi et al.
Daiki Nakatsu et al.
Published Erratum
Stem cell reports. 2023 May 9;18(5):1246. DOI:10.1016/j.stemcr.2023.03.017 2023
Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies [0.03%]
人多能干细胞来源的海马类器官：一种用于阿尔茨海默病患者特异性细胞表型分层和开发治疗的新工具
Yuriy Pomeshchik,Oxana Klementieva,Jeovanis Gil et al.
Yuriy Pomeshchik et al.
Published Erratum
Stem cell reports. 2023 May 9;18(5):1244-1245. DOI:10.1016/j.stemcr.2023.04.009 2023
Single-cell transcriptome analysis of xenotransplanted human retinal organoids defines two migratory cell populations of nonretinal origin [0.03%]
人视网膜类器官异种移植的单细胞转录组分析定义了两种非视网膜来源的迁移细胞群
Ying V Liu,Clayton P Santiago,Akin Sogunro et al.
Ying V Liu et al.
Human retinal organoid transplantation could potentially be a treatment for degenerative retinal diseases. How the recipient retina regulates the survival, maturation, and proliferation of transplanted organoid cells is unknown. We transpla...