Glutamine boosts intestinal stem cell-mediated small intestinal epithelial development during early weaning: Involvement of WNT signaling [0.03%]
谷氨酰胺通过WNT信号通路促进断奶前期小肠上皮发育及肠道干细胞介导的分化增殖
Junquan Tian,Yuying Li,Xuetai Bao et al.
Junquan Tian et al.
Early weaning usually causes small intestine epithelial development abnormality, increasing the risk of gastrointestinal diseases. Glutamine (Gln), enriching in plasma and milk, is widely reported to benefit intestinal health. However, whet...
AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype [0.03%]
AAV介导的CRB1患者源性视网膜类器官基因增强疗法可恢复组织学和转录视网膜表型
Nanda Boon,Xuefei Lu,Charlotte A Andriessen et al.
Nanda Boon et al.
Published Erratum
Stem cell reports. 2023 Jun 13;18(6):1388. DOI:10.1016/j.stemcr.2023.05.008 2023
Davi M Lyra-Leite,Raymond R Copley,Phillip P Freeman et al.
Davi M Lyra-Leite et al.
The nutritional requirements for human induced pluripotent stem cell (hiPSC) growth have not been extensively studied. Here, building on our prior work that established the suitable non-basal medium components for hiPSC growth, we develop a...
Jesse V Kurland,Alicia A Cutler,Jacob T Stanley et al.
Jesse V Kurland et al.
Skeletal muscle function and regenerative capacity decline during aging, yet factors driving these changes are incompletely understood. Muscle regeneration requires temporally coordinated transcriptional programs to drive myogenic stem cell...
Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment [0.03%]
人干细胞肺和心脏模型的平行使用为SARS-CoV-2治疗提供见解
Rajeev Rudraraju,Matthew J Gartner,Jessica A Neil et al.
Rajeev Rudraraju et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily infects the respiratory tract, but pulmonary and cardiac complications occur in severe coronavirus disease 2019 (COVID-19). To elucidate molecular mechanisms in the lung...
Enrichment of stem cell-derived pancreatic beta-like cells and controlled graft size through pharmacological removal of proliferating cells [0.03%]
通过药物去除增殖细胞的方法纯化干细胞来源的类似胰岛β细胞并控制移植物大小
Ali H Shilleh,Scott Beard,Holger A Russ
Ali H Shilleh
Transplantation of limited human cadaveric islets into type 1 diabetic patients results in ∼35 months of insulin independence. Direct differentiation of stem cell-derived insulin-producing beta-like cells (sBCs) that can reverse diabetes i...
MEF2C/p300-mediated epigenetic remodeling promotes the maturation of induced cardiomyocytes [0.03%]
MEF2C/p300介导的表观遗传重编程促进诱导心肌细胞成熟
Hidenori Kojima,Taketaro Sadahiro,Naoto Muraoka et al.
Hidenori Kojima et al.
Cardiac transcription factors (TFs) directly reprogram fibroblasts into induced cardiomyocytes (iCMs), where MEF2C acts as a pioneer factor with GATA4 and TBX5 (GT). However, the generation of functional and mature iCMs is inefficient, and ...
Organoids are not organs: Sources of variation and misinformation in organoid biology [0.03%]
类器官不是器官：类器官生物学变异和误传的来源
Kim Bak Jensen,Melissa Helen Little
Kim Bak Jensen
In the past decade, the term organoid has moved from obscurity to common use to describe a 3D in vitro cellular model of a tissue that recapitulates structural and functional elements of the in vivo organ it models. The term organoid is now...