An in silico and in vitro human neuronal network model reveals cellular mechanisms beyond NaV1.1 underlying Dravet syndrome [0.03%]
基于Nav1.1通道的人类神经元网络模型揭示特雷德尔综合征的发病机制
Nina Doorn,Eline J H van Hugte,Ummi Ciptasari et al.
Nina Doorn et al.
Human induced pluripotent stem cell (hiPSC)-derived neuronal networks on multi-electrode arrays (MEAs) provide a unique phenotyping tool to study neurological disorders. However, it is difficult to infer cellular mechanisms underlying these...
Ulgu Arslan,Marcella Brescia,Viviana Meraviglia et al.
Ulgu Arslan et al.
Functional vasculature is essential for delivering nutrients, oxygen, and cells to the heart and removing waste products. Here, we developed an in vitro vascularized human cardiac microtissue (MT) model based on human induced pluripotent st...
Single-cell analysis of human fetal epicardium reveals its cellular composition and identifies CRIP1 as a modulator of EMT [0.03%]
单细胞分析揭示人胎儿心外膜的细胞组成并鉴定出EMT调节因子CRIP1
Thomas J Streef,Esmee J Groeneveld,Tessa van Herwaarden et al.
Thomas J Streef et al.
The epicardium plays an essential role in cardiogenesis by providing cardiac cell types and paracrine cues to the developing myocardium. The human adult epicardium is quiescent, but recapitulation of developmental features may contribute to...
Unproven cell interventions in Poland and the exploitation of European Union law on advanced therapy medicinal products [0.03%]
波兰的细胞干预行为及对欧盟先进治疗药品法规的滥用
Józef Dulak,Marlena Pecyna
Józef Dulak
The global threat of unproven "stem cell therapies" develops despite the repeated statements of scientific organizations and regulatory agencies warning about the improper rationale, lack of effectiveness, and potential health risks of such...
Cell-autonomous and non-cell-autonomous roles of NKCC1 in regulating neural stem cell quiescence in the hippocampal dentate gyrus [0.03%]
顶囊沟齿状回区神经干细胞静息的NKCC1自主和非自主作用机制研究
Feng Zhang,Kijun Yoon,Nam-Shik Kim et al.
Feng Zhang et al.
Quiescence is a hallmark of adult neural stem cells (NSCs) in the mammalian brain, and establishment and maintenance of quiescence is essential for life-long continuous neurogenesis. How NSCs in the dentate gyrus (DG) of the hippocampus acq...
Evidence for in vitro extensive proliferation of adult hepatocytes and biliary epithelial cells [0.03%]
成人肝细胞和胆管上皮细胞体外大量增殖的证据
Takeshi Katsuda,Jonathan Sussman,Jinyang Li et al.
Takeshi Katsuda et al.
Over the last several years, a method has emerged that endows adult hepatocytes with in vitro proliferative capacity, producing chemically induced liver progenitors (CLiPs). However, there is a growing controversy regarding the origin of th...
Donor perspectives on informed consent and use of biospecimens for brain organoid research [0.03%]
供体对脑器官研究中生物样本知情同意和使用的意见
Katherine E MacDuffie,Jason L Stein,Dan Doherty et al.
Katherine E MacDuffie et al.
Debates about the ethics of human brain organoids have proceeded without the input of individuals whose brains are being modeled. Interviews with donors of biospecimens for brain organoid research revealed overall enthusiasm for brain organ...
Familial Alzheimer's disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling [0.03%]
早老素1基因突变通过增加诺特定理信号影响神经发育
Erin M Hurley,Pawel Mozolewski,Radek Dobrowolski et al.
Erin M Hurley et al.
Alzheimer's disease (AD) is the most common neurodegenerative disorder, but its root cause may lie in neurodevelopment. PSEN1 mutations cause the majority of familial AD, potentially by disrupting proper Notch signaling, causing early unnot...
Organoid models of breathing disorders reveal patterning defect of hindbrain neurons caused by PHOX2B-PARMs [0.03%]
呼吸障碍的类器官模型揭示了PHOX2B-PARMs引起的后脑神经元模式缺陷
Kathy Nga-Chu Lui,Zhixin Li,Frank Pui-Ling Lai et al.
Kathy Nga-Chu Lui et al.
Retrotrapezoid nucleus (RTN) neurons in the brainstem regulate the ventilatory response to hypercarbia. It is unclear how PHOX2B-polyalanine repeat mutations (PHOX2B-PARMs) alter the function of PHOX2B and perturb the formation of RTN neuro...
Serine Racemase mediates subventricular zone neurogenesis via fatty acid metabolism [0.03%]
丝氨酸 racemase 通过脂肪酸代谢调节侧脑室室管膜下区的神经发生
Robin Roychaudhuri,Hasti Atashi,Solomon H Snyder
Robin Roychaudhuri
The adult subventricular zone (SVZ) is a neurogenic niche that continuously produces newborn neurons. Here we show that serine racemase (SR), an enzyme that catalyzes the racemization of L-serine to D-serine and vice versa, affects neurogen...