Vincenzo Cardinale,Nicolas Lanthier,Pedro M Baptista et al.
Vincenzo Cardinale et al.
This review aims to evaluate the current preclinical state of liver bioengineering, the clinical context for liver cell therapies, the cell sources, the delivery routes, and the results of clinical trials for end-stage liver disease. Differ...
Designing persuasive health education for patients seeking unproven stem cell interventions [0.03%]
针对寻求缺乏证据支持的干细胞治疗患者的有说服力的健康教育设计
Omar Kawam,Xuan Zhu,David T Eton et al.
Omar Kawam et al.
Misinformation among clinics advertising unproven stem cell interventions (SCIs) is pervasive and has resulted in patient and societal harms. Most bioethics commentaries have centered on advancing regulatory approaches to curtail the supply...
Kazuo Takayama,Shinya Yamanaka
Kazuo Takayama
VE-CADHERIN is expressed transiently in early ISL1+ cardiovascular progenitor cells and facilitates cardiac differentiation [0.03%]
VE-钙粘蛋白在早期ISL1+心血管祖细胞中短暂表达并促进心脏分化
Violetta A Maltabe,Anna N Melidoni,Dimitris Beis et al.
Violetta A Maltabe et al.
Adherens junctions (AJs) provide adhesive properties through cadherins and associated cytoplasmic catenins and participate in morphogenetic processes. We examined AJs formed between ISL1+ cardiovascular progenitor cells during differentiati...
CRB1 is required for recycling by RAB11A+ vesicles in human retinal organoids [0.03%]
CRB1需要RAB11A+囊泡在人视网膜类器官中的回收功能
Thilo M Buck,Peter M J Quinn,Lucie P Pellissier et al.
Thilo M Buck et al.
CRB1 gene mutations can cause early- or late-onset retinitis pigmentosa, Leber congenital amaurosis, or maculopathy. Recapitulating human CRB1 phenotypes in animal models has proven challenging, necessitating the development of alternatives...
Platform-agnostic CellNet enables cross-study analysis of cell fate engineering protocols [0.03%]
平台无关的CellNet使细胞命运工程方案跨研究分析成为可能
Emily K W Lo,Jeremy J Velazquez,Da Peng et al.
Emily K W Lo et al.
Optimization of cell engineering protocols requires standard, comprehensive quality metrics. We previously developed CellNet, a computational tool to quantitatively assess the transcriptional fidelity of engineered cells compared with their...
Transcriptomic differences between human 8-cell-like cells reprogrammed with different methods [0.03%]
不同方法重编程的人类8细胞类似体的转录组差异
Masahito Yoshihara,Juha Kere
Masahito Yoshihara
Embryonic genome activation (EGA) is a critical step in embryonic development. However, while EGA has been studied in mice using mouse 2-cell-like cells, human EGA remains incompletely elucidated due to the lack of an in vitro cell model re...
Am80, a retinoic acid receptor agonist, activates the cardiomyocyte cell cycle and enhances engraftment in the heart [0.03%]
AM80，一种视黄酸受体激动剂，可激活心肌细胞周期并增强心脏植入能力
Manabu Kasamoto,Shunsuke Funakoshi,Takeshi Hatani et al.
Manabu Kasamoto et al.
Human induced pluripotent stem cell-derived (hiPSC) cardiomyocytes are a promising source for regenerative therapy. To realize this therapy, however, their engraftment potential after their injection into the host heart should be improved. ...
A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells [0.03%]
人多能干细胞向放射状胶质细胞和星形胶质细胞分化的路线图
Vukasin M Jovanovic,Claire Weber,Jaroslav Slamecka et al.
Vukasin M Jovanovic et al.
Human gliogenesis remains poorly understood, and derivation of astrocytes from human pluripotent stem cells (hPSCs) is inefficient and cumbersome. Here, we report controlled glial differentiation from hPSCs that bypasses neurogenesis, which...
Minichromosome maintenance protein 10 (mcm10) regulates hematopoietic stem cell emergence in the zebrafish embryo [0.03%]
minichromosome 维护蛋白10（mcm10）调控斑马鱼胚胎中的造血干细胞的产生
Pietro Cacialli,Serkan Dogan,Tanja Linnerz et al.
Pietro Cacialli et al.
Hematopoietic stem cells (HSCs) guarantee the continuous supply of all blood lineages during life. In response to stress, HSCs are capable of extensive proliferative expansion, whereas in steady state, HSCs largely remain in a quiescent sta...