Human model of primary carnitine deficiency cardiomyopathy reveals ferroptosis as a novel mechanism [0.03%]
原发性肉碱缺乏心肌病人类模型揭示新型致病机制铁死亡
Malte Loos,Birgit Klampe,Thomas Schulze et al.
Malte Loos et al.
Primary carnitine deficiency (PCD) is an autosomal recessive monogenic disorder caused by mutations in SLC22A5. This gene encodes for OCTN2, which transports the essential metabolite carnitine into the cell. PCD patients suffer from muscula...
Creating an HLA-homozygous iPS cell bank for the Brazilian population: Challenges and opportunities [0.03%]
创建巴西人口HLA同种异体的iPSC库：挑战与机遇
Marcio Lassance Martins de Oliveira,Bernardo Rangel Tura,Mauro Meira Leite et al.
Marcio Lassance Martins de Oliveira et al.
Identifying human leukocyte antigen (HLA) haplotype-homozygous donors for the generation of induced pluripotent stem (iPS) cell lines permits the construction of biobanks immunologically compatible with significant numbers of individuals fo...
Highly contractile 3D tissue engineered skeletal muscles from human iPSCs reveal similarities with primary myoblast-derived tissues [0.03%]
取自人类iPSC的工程化三维骨骼肌组织具有与原代肌管相似的收缩性
Erik van der Wal,Alessandro Iuliano,Stijn L M In &#x;t Groen et al.
Erik van der Wal et al.
Skeletal muscle research is transitioning toward 3D tissue engineered in vitro models reproducing muscle's native architecture and supporting measurement of functionality. Human induced pluripotent stem cells (hiPSCs) offer high yields of c...
Seamless and non-destructive monitoring of extracellular microRNAs during cardiac differentiation from human pluripotent stem cells [0.03%]
人多能干细胞心脏分化过程中外泌体 miRNA 的无损监测方法
Otoya Sekine,Sayaka Kanaami,Kanako Masumoto et al.
Otoya Sekine et al.
Monitoring cardiac differentiation and maturation from human pluripotent stem cells (hPSCs) and detecting residual undifferentiated hPSCs are indispensable for the development of cardiac regenerative therapy. MicroRNA (miRNA) is secreted fr...
How to promote the accessibility of technology in the era of hESC patents-A comparative analysis of the systems of the US and China [0.03%]
促进胚胎干细胞专利时代的技术可及性研究——中美两国制度之比较分析
Wei Zhang,Jiajv Chen,Wei Li et al.
Wei Zhang et al.
We have entered the era of human embryonic stem cell (hESC) patents and the focus of discussion has shifted to how to rebalance interests. A potential way is to limit hESC patents and seek more effective utilization forms, such as ethical l...
Single-cell characterization of neovascularization using hiPSC-derived endothelial cells in a 3D microenvironment [0.03%]
基于hiPSC的血管内皮细胞在三维微环境中的单细胞新生血管化表征
Simon Rosowski,Caroline Remmert,Maren Marder et al.
Simon Rosowski et al.
The formation of vascular structures is fundamental for in vitro tissue engineering. Vascularization can enable the nutrient supply within larger structures and increase transplantation efficiency. We differentiated human induced pluripoten...
SnapShot: Reporting practices for publishing results with human PSCs and tissue stem cells [0.03%]
报告实践：使用人类PSC和组织干细胞发布结果的出版物中的报告实践
ISSCR Task Force for Basic Research Standards. Electronic address: tludwig@wicell.org
ISSCR Task Force for Basic Research Standards. Electronic address: tludwig@wicell.org
This checklist is intended to help scientists, reviewers, and editors prepare and assess manuscripts for inclusion of critical details relevant to work with pluripotent stem cells (PSCs) and tissue stem cells (TSCs) with the goal of increas...
A functional crosstalk between the H3K9 methylation writers and their reader HP1 in safeguarding embryonic stem cell identity [0.03%]
H3K9甲基化酶与识别蛋白HP1的功能互作维持胚胎干细胞身份
Lixia Dong,Huaqi Liao,Linchun Zhao et al.
Lixia Dong et al.
Histone H3 lysine 9 (H3K9) methylation, as a hallmark of heterochromatin, has a central role in cell lineage and fate determination. Although evidence of a cooperation between H3K9 methylation writers and their readers has started to emerge...
Genome-wide loss-of-function screen using human pluripotent stem cells to study virus-host interactions for SARS-CoV-2 [0.03%]
基于人多能干细胞的全基因组功能缺失筛选研究SARS-CoV-2病毒与宿主相互作用
Ariel Pagis,Or Alfi,Shay Kinreich et al.
Ariel Pagis et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019, has become a global health concern. Therefore, there is an immense need to understand the network of virus-host interactions by u...
ISSCR standards for the use of human stem cells in basic research [0.03%]
国际干细胞研究学会关于人类干细胞基础研究使用标准的声明
Tenneille E Ludwig,Peter W Andrews,Ivana Barbaric et al.
Tenneille E Ludwig et al.
The laboratory culture of human stem cells seeks to capture a cellular state as an in vitro surrogate of a biological system. For the results and outputs from this research to be accurate, meaningful, and durable, standards that ensure repr...