Proteomics-based receptor-ligand matching enhances differentiation maturity of human-stem-cell-derived neurons [0.03%]
基于蛋白质组的受体-配体匹配可增强人类干细胞来源神经元的分化成熟度
Dimitar Dimitrov,Yi Lien,Tetsuya Hori et al.
Dimitar Dimitrov et al.
Human-induced pluripotent stem cell (hiPSC) technology enables generation of various cell types, offering significant potential for regenerative medicine and personalized disease modeling. However, optimizing the functional maturity of diff...
Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoids [0.03%]
利用人脑类器官鉴定出胸腺素β4可作为阿尔茨海默病的干预靶点
Peng-Ming Zeng,Xin-Yao Sun,Yang Li et al.
Peng-Ming Zeng et al.
The developmental origin of Alzheimer disease (AD) has been proposed but is arguably debated. Here, we developed cerebral organoids from induced pluripotent stem cells (iPSCs) with mutations in amyloid precursor protein (APP) associated wit...
Germline transmission of cryopreserved mouse spermatogonial stem cells maintained on the International Space Station [0.03%]
国际空间站冷冻保存的小鼠 spermatogonial 干细胞系的种系传递
Mito Kanatsu-Shinohara,Takuya Yamamoto,Yusuke Shiromoto et al.
Mito Kanatsu-Shinohara et al.
Despite growing interest in space exploration, the effects of spaceflight on stem cells remain largely unknown. Damages to germline cells are especially crucial, as spaceflight poses risks to gametogenesis, with abnormalities observed in mu...
Adult hippocampal neurogenesis: New avenues for treatment of brain disorders [0.03%]
成人海马神经发生：治疗脑疾病的新途径
Liying Chen,Zhongxia Li,Wenqi Wang et al.
Liying Chen et al.
Neurogenesis, the biological process of forming new neurons, was traditionally believed to occur only during embryonic stages in the mammalian central nervous system for a long time. Over the past few decades, due to the development of new ...
Transcription factor-mediated germ cell induction in rats reveals ETV4 cooperates with germline specifiers [0.03%]
转录因子介导的大鼠生殖细胞诱导显示ETV4与生殖系决定因子协同作用
Mami Oikawa,Hiroki Kojima,Hisato Kobayashi et al.
Mami Oikawa et al.
The specification of primordial germ cells (PGCs) marks a crucial branchpoint in early embryonic development. Studying the molecular mechanisms governing this process is crucial for understanding reproduction and evolution. Here, we identif...
PML is crucial for neural stem cell differentiation, stress tolerance and mitochondrial integrity [0.03%]
PML对神经干细胞分化、压力耐受和线粒体完整性至关重要
Syrago Spanou,Takis Makatounakis,Elena Deligianni et al.
Syrago Spanou et al.
The tumor suppressor promyelocytic leukemia protein (PML) has important roles in brain development; however, the molecular and cellular pathways regulated by PML in neuronal cells remain largely unknown. To address this issue, we analyzed g...
Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells [0.03%]
抑制Nodal信号活性使胚外分化倾向于表皮干细胞
Chang Liu,Ran Wang,Zhisong He et al.
Chang Liu et al.
Published Erratum
Stem cell reports. 2025 Aug 4:102609. DOI:10.1016/j.stemcr.2025.102609 2025
Modeling glioma intratumoral heterogeneity with primary human neural stem and progenitor cells [0.03%]
用原代人类神经干细胞和祖细胞模拟胶质瘤异质性
Daniel Dan Liu,Daniel Gao,Nicole L Womack-Gambrel et al.
Daniel Dan Liu et al.
Gliomas are notorious for their intratumoral heterogeneity, which drives therapy resistance. Glioma tumor cells mimic a neural stem cell (NSC) hierarchy reminiscent of normal brain development. How intratumoral heterogeneity is shaped by ce...
Impaired DNA damage responses and inflammatory signaling underpin hematopoietic stem cell defects in Gata2 haploinsufficiency [0.03%]
GATA2半倍合子不足下造血干细胞缺陷源于受损的DNA损伤反应和炎症信号转导异常
Ali Abdelfattah,Ahmad Habib,Leigh-Anne Thomas et al.
Ali Abdelfattah et al.
Clinical GATA2 haploinsufficiency results in immunodeficiency that evolves to leukemia. How GATA2 haploinsufficiency disrupts the functionality of hematopoietic stem/progenitor cells (HSCs/HSPCs) to facilitate pre-leukemia development is po...
Establishment of neuronal and glial competence of neural stem cells requires distinct enzymatic activities of TET enzymes [0.03%]
TET酶的不同的酶活活性决定了神经干细胞获得神经元和胶质细胞潜能
Blake C Ebert,Ian C MacArthur,Harmony C Ketchum et al.
Blake C Ebert et al.
Ten-eleven translocation (TET1/2/3) enzymes are expressed in neural stem cells (NSCs). They iteratively oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). The significanc...