Integration of the naive pluripotency gene network with the response to GSK3 inhibition by Tcf7l1-driven enhancer decommissioning [0.03%]
Tcf7l1通过驱动增强子去激活实现使 naive多能性基因网络与GSK3抑制反应相结合
Jieun Kwon,Jenny Y Zhang,Brian R Shy et al.
Jieun Kwon et al.
The transition out of naive pluripotency requires the simultaneous dissolution of the naive gene regulatory network as well as a redirection of transcriptional response to WNT/β-CATENIN signaling. Here, we show that Tcf7l1 functions as a l...
Neural stem cells as potential mediators of prenatal dietary stress through epigenetic mechanisms [0.03%]
神经干细胞通过表观遗传机制作为宫内饮食压力的潜在介体
Itsuki Kageyama,Hiroya Yamada,Mirai Yamazaki et al.
Itsuki Kageyama et al.
The developmental origins of health and disease (DOHaD) hypothesis suggests that environmental exposures during development can induce long-term health effects, yet the cellular origin of such persistence remains unclear. Here, we suggest t...
BDNF regulates pituitary stem cell engagement toward precursor state [0.03%]
脑源性神经营养因子通过调节干细胞进入类祖细胞状态来调控垂体前体干细胞的增殖分化
Kevin Sochodolsky,Konstantin Khetchoumian,Aurelio Balsalobre et al.
Kevin Sochodolsky et al.
Following their engagement toward differentiation, tissue stem cells often transit through a precursor state that is difficult to define because of its transient nature; similarly, the precise role of lineage precursors in the implementatio...
Atg5 deficiency alters myofibroblast accumulation and alveolar regeneration in lung fibrosis [0.03%]
ATG5缺陷通过改变肌成纤维细胞的积累和肺纤维化中的Ⅱ型肺泡细胞再生来抑制肺修复反应
Xue Li,Guiying Xu,Qi Wang et al.
Xue Li et al.
Lung fibrosis progression is marked by impaired alveolar epithelial regeneration and uncontrolled myofibroblast differentiation, though the underlying mechanisms remain poorly understood. In this study, we discovered that Atg5 was upregulat...
aPKC-ζ III promotes trophoblast fusion by altering Par-3 interactions with Hippo signaling kinase LATS1 [0.03%]
aPKC-ζ III通过改变Par-3与Hippo信号通路激酶LATS1的相互作用促进滋养层融合
Sumaiyah Z Shaha,Wendy K Duan,Juan Garcia Rivas et al.
Sumaiyah Z Shaha et al.
The first trimester of pregnancy is a critical developmental period for the placenta. In humans, the maternal-facing exchange surface is formed by a single giant multinucleate syncytium: the syncytiotrophoblast (ST). The ST arises from vill...
A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells [0.03%]
一种高效地区分人诱导多能干细胞中表达CGRP的肽能伤害性感觉神经元的方法
Galbha Duggal,Xinyu Li,Philippa Pettingill et al.
Galbha Duggal et al.
Pain disorders such as neuropathic pain and headache remain areas of considerable unmet need and considered high risk by pharma. Human-induced pluripotent stem cells (iPSC)-derived sensory neurons have already been used to accelerate transl...
Elevated mitochondrial Ca2+ impairs satellite cell pool expansion in response to skeletal muscle injury [0.03%]
线粒体钙离子升高通过损伤诱导的卫星细胞扩增缺陷促进肌肉再生不良
Ahmed S Shams,Lalitha S Denduluri,Megan K Sumera et al.
Ahmed S Shams et al.
MICU1 loss-of-function variants in human patients are associated with proximal muscle weakness and myopathy. Mitochondrial Ca2+ levels are basally elevated when MICU1, the gatekeeper of the mitochondrial Ca2+ uniporter, is absent. The impor...
Integrative analysis of drug-gene signatures in human pluripotent stem cells reveals prazosin as a novel SQSTM1 regulator for ALS therapeutics [0.03%]
整合分析人类多能干细胞中的药物基因特征揭示了普唑嗪是治疗ALS的新型SQSTM1调节剂
Florine Roussange,Jacqueline Gide,Johana Tournois et al.
Florine Roussange et al.
The classical paradigm of drug screening often faces significant limitations due to the challenges associated with identifying molecular or cellular read-outs that are relevant to specific genetic diseases. To remedy this, an alternative ap...
Ubaka Ogbogu
Ubaka Ogbogu
This paper discusses China's State Council Order No. 818, effective May 1, 2026, which establishes a statutory framework for biomedical technologies at the cellular and molecular levels. The framework is uniquely intervention-based rather t...
Laetitia Aubry,Viktor I Korolchuk,Sovan Sarkar
Laetitia Aubry
Drug screening for genetic disorders is limited by difficulty identifying disease-relevant phenotypes. In this issue, Roussange et al., show that reverse phenotypic mapping could uncover therapeutic gene expression signatures. Using this ap...