Induction of local immunosuppression in allogeneic cell transplantation by cell-type-specific expression of PD-L1 and CTLA4Ig [0.03%]
选择性诱导PD-L1和CTLA4Ig表达以实现异基因细胞移植的局部免疫耐受
Wenliang Zhu,Mengqi Li,Jun Zou et al.
Wenliang Zhu et al.
Immune rejection has long hindered allogeneic cell transplantation therapy. Current genetic modification approaches, including direct targeting of major histocompatibility complex or constitutive expression of immune inhibitory molecules, e...
A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases [0.03%]
COL4A1/A2型小血管病的人类iPSC新模型揭露了基质金属蛋白酶的关键致病作用
Maha Al-Thani,Mary Goodwin-Trotman,Steven Bell et al.
Maha Al-Thani et al.
Cerebral small vessel disease (SVD) affects the small vessels in the brain and is a leading cause of stroke and dementia. Emerging evidence supports a role of the extracellular matrix (ECM), at the interface between blood and brain, in the ...
Ribosome biogenesis controls cranial suture MSC fate via the complement pathway in mouse and human iPSC models [0.03%]
核糖体生物发生通过补体途径控制小鼠和人类iPSC模型颅缝MSC命运
Supawadee Jariyasakulroj,Wei Zhang,Jianhui Bai et al.
Supawadee Jariyasakulroj et al.
Disruption of global ribosome biogenesis selectively affects craniofacial tissues with unclear mechanisms. Craniosynostosis is a congenital craniofacial disorder characterized by premature fusion of cranial suture(s) with loss of suture mes...
Integration of xeno-free single-cell cloning in CRISPR-mediated DNA editing of human iPSCs improves homogeneity and methodological efficiency of cellular disease modeling [0.03%]
无异种因子单细胞克隆技术结合CRISPR基因编辑技术可提高人类iPSCs疾病建模的均一性和方法效率
Atefeh Namipashaki,Kealan Pugsley,Xiaodong Liu et al.
Atefeh Namipashaki et al.
The capability to generate induced pluripotent stem cell (iPSC) lines, in tandem with CRISPR-Cas9 DNA editing, offers great promise to understand the underlying genetic mechanisms of human disease. The low efficiency of available methods fo...
Does the Act on the Safety of Regenerative Medicine in Japan ensure "safety"?: Implications of low adverse event reporting [0.03%]
日本《再生医学安全法》确保了“安全”吗？——基于低不良事件报告的思考
Tsunakuni Ikka,Taichi Hatta,Yoko Saito et al.
Tsunakuni Ikka et al.
Public document analysis reveals that the adverse events reported for therapeutic administration under the Act on the Safety of Regenerative Medicine (ASRM) in Japan are substantially fewer than those under the Pharmaceuticals and Medical D...
Justin Brumbaugh,Brian A Aguado,Tamra Lysaght et al.
Justin Brumbaugh et al.
Human fetal tissue and cells derived from fetal tissue are crucial for biomedical research. Fetal tissues and cells are used to study both normal development and developmental disorders. They are broadly applied in vaccine development and p...
Pharmacologic enhancement of retromer rescues endosomal pathology induced by defects in the Alzheimer's gene SORL1 [0.03%]
药物增强retromer可修复阿尔茨海默病基因SORL1缺陷引起的胞吞囊泡运输病理损害
Swati Mishra,Allison Knupp,Chizuru Kinoshita et al.
Swati Mishra et al.
The SORL1 gene (SORLA) is strongly associated with risk of developing Alzheimer's disease (AD). SORLA is a regulator of endosomal trafficking in neurons and interacts with retromer, a complex that is a "master conductor" of endosomal traffi...
Efficient derivation of transgene-free porcine induced pluripotent stem cells enables in vitro modeling of species-specific developmental timing [0.03%]
高效地获得无转基因诱导多能性的猪干细胞，可在体外建立物种特异性发育时间模型
J Vanessa Conrad,Susanne Meyer,Pranav S Ramesh et al.
J Vanessa Conrad et al.
Sus scrofa domesticus (pig) has served as a superb large mammalian model for biomedical studies because of its comparable physiology and organ size to humans. The derivation of transgene-free porcine induced pluripotent stem cells (PiPSCs) ...
MSCohi-O lenses for long-term retention of mesenchymal stem cells on ocular surface as a therapeutic approach for chronic ocular graft-versus-host disease [0.03%]
用于眼科移植抗原宿主病的长期治疗性角膜塑形镜保留间充质干细胞的研究
Yuanyue Liu,Siqi Song,Youyu Liu et al.
Yuanyue Liu et al.
Chronic ocular graft-versus-host disease (oGVHD) is a common complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and can lead to vision loss if not diagnosed and treated promptly. Currently, no approved drugs exis...
Identification of glioblastoma stem cell-associated lncRNAs using single-cell RNA sequencing datasets [0.03%]
利用单细胞RNA测序数据集识别胶质母细胞瘤干细胞相关的长链非编码RNA
Rasmani Hazra,Raditya Utama,Payal Naik et al.
Rasmani Hazra et al.
Glioblastoma multiforme (GBM) is an aggressive, heterogeneous brain tumor in which glioblastoma stem cells (GSCs) are known culprits of therapy resistance. Long non-coding RNAs (lncRNAs) have been shown to play a critical role in both cance...