C/EBPβ-induced lymphoid-to-myeloid transdifferentiation emulates granulocyte-monocyte progenitor biology [0.03%]
C/EBPβ诱导的淋巴向髓样转分化模拟了粒单祖细胞的生物学特性
Linh Thuy Nguyen,Karin Zimmermann,Elisabeth Kowenz-Leutz et al.
Linh Thuy Nguyen et al.
CCAAT/enhancer-binding protein beta (C/EBPβ) induces primary v-Abl immortalized mouse B cells to transdifferentiate (BT, B cell transdifferentiation) into granulocyte-macrophage progenitor-like cells (GMPBTs). GMPBTs maintain cytokine-inde...
Gains of 20q11.21 in human pluripotent stem cells: Insights from cancer research [0.03%]
人类多能干细胞中20q11.21的增益：来自癌症研究的见解
Nuša Krivec,Manjusha S Ghosh,Claudia Spits
Nuša Krivec
The genetic abnormalities observed in hPSC cultures worldwide have been suggested to pose an important hurdle in their safe use in regenerative medicine due to the possibility of oncogenic transformation by mutant cells in the patient postt...
Peter W Andrews,Paul J Gokhale
Peter W Andrews
The expression of one or more of a small number of molecules, typically cell surface-associated antigens, or transcription factors, is widely used for identifying pluripotent stem cells (PSCs) or for monitoring their differentiation. Howeve...
Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems [0.03%]
迈向人类特异性非动物方法的飞跃：微生理系统全球政策协调的需求
Surat Parvatam,David Pamies,Francesca Pistollato et al.
Surat Parvatam et al.
With a recent amendment, India joined other countries that have removed the legislative barrier toward the use of human-relevant methods in drug development. Here, global stakeholders weigh in on the urgent need to globally harmonize the gu...
Transparency in controversial research: A review of human embryo research publication ethical disclosure statements [0.03%]
有争议的研究中的透明度：对人胚胎研究出版道德披露声明的评审
Akshaya Venkatesh,Ana S Iltis,Kirstin R W Matthews
Akshaya Venkatesh
In 2021, the International Society for Stem Cell Research (ISSCR) released updated guidelines that included human embryo research guidance. Requiring ethics statements in publications using human embryos is one way to verify adherence to th...
Interspecies chimerism with human embryonic stem cells generates functional human dopamine neurons at low efficiency [0.03%]
人胚胎干细胞的跨物种嵌合低效生成功能性的人多巴胺神经元
Hu Wang,Xiling Yin,Jinchong Xu et al.
Hu Wang et al.
Interspecies chimeras offer great potential for regenerative medicine and the creation of human disease models. Whether human pluripotent stem cell-derived neurons in an interspecies chimera can differentiate into functional neurons and int...
Subcellular RNA distribution and its change during human embryonic stem cell differentiation [0.03%]
人类胚胎干细胞分化过程中的亚细胞RNA分布及其变化
Fanqi Zhou,Puwen Tan,Siqi Liu et al.
Fanqi Zhou et al.
The spatial localization of RNA within cells is closely related to its function and also involved in cell fate determination. However, the atlas of RNA distribution within cells and dynamic changes during the developmental process are large...
Generation of canine induced pluripotent stem cells under feeder-free conditions using Sendai virus vector encoding six canine reprogramming factors [0.03%]
使用塞内加尔病毒载体编码六种犬重编程因子在无饲养层条件下生成犬诱导多能干细胞
Masaya Tsukamoto,Kazuto Kimura,Takumi Yoshida et al.
Masaya Tsukamoto et al.
Although it is in its early stages, canine induced pluripotent stem cells (ciPSCs) hold great potential for innovative translational research in regenerative medicine, developmental biology, drug screening, and disease modeling. However, al...
Riccardo De Santis,Eleni Rice,Gist Croft et al.
Riccardo De Santis et al.
While studied extensively in model systems, human gastrulation remains obscure. The scarcity of fetal biological material as well as ethical considerations limit our understanding of this process. In vitro attachment of natural blastocysts ...
Distinct roles of hematopoietic cytokines in the regulation of leukemia stem cells in murine MLL-AF9 leukemia [0.03%]
造血细胞因子在小鼠MLL(AF9)白血病干细胞调节中的不同作用
Yanchun Li,Christopher S Seet,Ryan Mack et al.
Yanchun Li et al.
Lymphoid-primed multipotent progenitor (LMPP)-like and granulocyte-monocyte progenitor (GMP)-like leukemia stem cells (LSCs) co-exist in the blood of most patients with acute myeloid leukemia (AML). Complete elimination of both types of LSC...