The impact of timing and injury mode on induced neurogenesis in the adult mammalian retina [0.03%]
时机和损伤方式对成年哺乳动物视网膜诱导神经发生的影响
Marina Pavlou,Marlene Probst,Nicolai Blasdel et al.
Marina Pavlou et al.
Regeneration of neurons has important implications for human health, and the retina provides an accessible system to study the potential of replacing neurons following injury. In previous work, we generated transgenic mice in which neurogen...
Searching for information about stem cells online in an age of artificial intelligence: How should the stem cell community respond? [0.03%]
人工智能时代在线查找干细胞信息：干细胞领域应如何应对？
Klaus Hoeyer,Anna Couturier,Kali Barawi et al.
Klaus Hoeyer et al.
Patients and their families routinely use the Internet to learn about stem cell research. What they find, is increasingly influenced by ongoing changes in how information is filtered and presented online. This article reflects on recent dev...
Proinflammatory phenotype of iPS cell-derived JAK2 V617F megakaryocytes induces fibrosis in 3D in vitro bone marrow niche [0.03%]
iPS细胞衍生的JAK2 V617F巨核细胞在三维体外骨髓生态位中诱导纤维化表现出促炎表型
Niclas Flosdorf,Janik Böhnke,Marcelo A S de Toledo et al.
Niclas Flosdorf et al.
The myeloproliferative disease polycythemia vera (PV) driven by the JAK2 V617F mutation can transform into myelofibrosis (post-PV-MF). It remains an open question how JAK2 V617F in hematopoietic stem cells induces MF. Megakaryocytes are maj...
Mutations in FUS lead to synaptic dysregulation in ALS-iPSC derived neurons [0.03%]
FUS基因突变导致ALS-iPSC衍生神经元的突触调节异常
Carole Shum,Erin C Hedges,Joseph Allison et al.
Carole Shum et al.
Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset neurodegenerative disorder characterized by progressive muscular weakness due to the selective loss of motor neurons. Mutations in the gene Fused in Sarcoma (FUS) were identified a...
Jiaming Gu,Yanling Zhu,Huaisong Lin et al.
Jiaming Gu et al.
Emergency myelopoiesis (EM) is essential in immune defense against pathogens for rapid replenishing of mature myeloid cells. During the EM process, a rapid cell-cycle switch from the quiescent hematopoietic stem cells (HSCs) to highly proli...
Deciphering the differential impact of thrombopoietin/MPL signaling on hematopoietic stem/progenitor cell function in bone marrow and spleen [0.03%]
血小板生成素/MPL信号对骨髓和脾中血液干/祖细胞功能的差异影响解析
Sandy Lee,Huichun Zhan
Sandy Lee
Thrombopoietin (TPO) and its receptor MPL play crucial roles in hematopoietic stem cell (HSC) function and platelet production. However, the precise effects of TPO/MPL signaling on HSC regulation in different hematopoietic niches remain unc...
Transcription factor co-expression mediates lineage priming for embryonic and extra-embryonic differentiation [0.03%]
转录因子的共表达介导了胚胎和胚外分化谱系的启动
Alba Redó-Riveiro,Jasmina Al-Mousawi,Madeleine Linneberg-Agerholm et al.
Alba Redó-Riveiro et al.
In early mammalian development, cleavage stage blastomeres and inner cell mass (ICM) cells co-express embryonic and extra-embryonic transcriptional determinants. Using a protein-based double reporter we identify an embryonic stem cell (ESC)...
SinCMat: A single-cell-based method for predicting functional maturation transcription factors [0.03%]
SinCMat：一种基于单细胞预测功能成熟转录因子的方法
Sybille Barvaux,Satoshi Okawa,Antonio Del Sol
Sybille Barvaux
A major goal of regenerative medicine is to generate tissue-specific mature and functional cells. However, current cell engineering protocols are still unable to systematically produce fully mature functional cells. While existing computati...
Engineering human pluripotent stem cell lines to evade xenogeneic transplantation barriers [0.03%]
工程改造人多能干细胞系以逃避异种移植屏障
Hannah A Pizzato,Paula Alonso-Guallart,James Woods et al.
Hannah A Pizzato et al.
Successful allogeneic human pluripotent stem cell (hPSC)-derived therapies must overcome immunological rejection by the recipient. To build reagents to define these barriers, we genetically ablated β2M, TAP1, CIITA, CD74, MICA, and MICB to...
Label-free enrichment of human pluripotent stem cell-derived early retinal progenitor cells for cell-based regenerative therapies [0.03%]
用于细胞再生疗法的人多能干细胞衍生的早期视网膜祖细胞的无标签富集
Yasuaki Iwama,Hiroko Nomaru,Tomohiro Masuda et al.
Yasuaki Iwama et al.
Pluripotent stem cell-based therapy for retinal degenerative diseases is a promising approach to restoring visual function. A clinical study using retinal organoid (RO) sheets was recently conducted in patients with retinitis pigmentosa. Ho...