Mitochondrial DNA integrity and metabolome profile are preserved in the human induced pluripotent stem cell reference line KOLF2.1J [0.03%]
人类诱导多能干细胞参考系KOLF2.1J中线粒体DNA完整性及代谢组谱系得以保持
Jochen Dobner,Thach Nguyen,Andreas Dunkel et al.
Jochen Dobner et al.
Quality control of human induced pluripotent stem cells (iPSCs) is critical to ensure reproducibility of research. Recently, KOLF2.1J was characterized and published as a male iPSC reference line to study neurological disorders. Emerging ev...
Human-induced pluripotent stem cell-derived neural stem/progenitor cell ex vivo gene therapy with synaptic organizer CPTX for spinal cord injury [0.03%]
用于脊髓损伤的体外神经干细胞/祖细胞的人工诱导多能干细胞衍生突触组织者CPTX基因治疗
Yusuke Saijo,Narihito Nagoshi,Momotaro Kawai et al.
Yusuke Saijo et al.
The transplantation of neural stem/progenitor cells (NS/PCs) derived from human induced pluripotent stem cells (hiPSCs) has shown promise in spinal cord injury (SCI) model animals. Establishing a functional synaptic connection between the t...
Growth/differentiation factor 15 controls ependymal and stem cell number in the V-SVZ [0.03%]
生长/分化因子15控制V-SVZ中室管膜细胞和干细胞的数量
Katja Baur,Carmen Carrillo-García,Şeydanur Şan et al.
Katja Baur et al.
The expression of growth/differentiation factor (GDF) 15 increases in the ganglionic eminence (GE) late in neural development, especially in neural stem cells (NSCs). However, GDF15 function in this region remains unknown. We report that GD...
Human iPSC-derived photoreceptor transplantation in the cone dominant 13-lined ground squirrel [0.03%]
锥体为主的十三线地松鼠中的人iPSC来源视网膜感光细胞移植
Ching Tzu Yu,Sangeetha Kandoi,Ramesh Periasamy et al.
Ching Tzu Yu et al.
Several retinal degenerations affect the human central retina, which is primarily comprised of cones and is essential for high acuity and color vision. Transplanting cone photoreceptors is a promising strategy to replace degenerated cones i...
Misidentification of neural cell identity in liver-derived organoid systems [0.03%]
肝源类器官系统中神经细胞身份的误识别
Imre F Schene,Arif I Ardisasmita,Sabine A Fuchs
Imre F Schene
Give heart cells a beat: An interactive museum exhibit that synchronizes stem cell-derived cardiomyocytes to visitors' heartbeat [0.03%]
给心细胞带上节拍：一个让干细胞衍生的心肌细胞与游客心跳同步的互动博物馆展品
Juan A Perez-Bermejo,Samuel J Reisman,Joyce Ma et al.
Juan A Perez-Bermejo et al.
Science museums play an important role in science education, engaging the public with science concepts and building support for scientific research. Here, we describe Give Heart Cells a Beat, an interactive exhibit that lets museum visitors...
ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development [0.03%]
内质网压力和脂质失衡驱动人类心脏发育类器官模型中的糖尿病胚胎心肌病
Aleksandra Kostina,Yonatan R Lewis-Israeli,Mishref Abdelhamid et al.
Aleksandra Kostina et al.
Congenital heart defects are the most prevalent human birth defects, and their incidence is exacerbated by maternal health conditions, such as diabetes during the first trimester (pregestational diabetes). Our understanding of the pathology...
ALS-related p97 R155H mutation disrupts lysophagy in iPSC-derived motor neurons [0.03%]
与ALS相关的p97 R155H突变会扰乱iPSC衍生的运动神经元中的溶酶体自噬过程
Jacob A Klickstein,Michelle A Johnson,Pantelis Antonoudiou et al.
Jacob A Klickstein et al.
Mutations in the AAA+ ATPase p97 cause multisystem proteinopathy 1, which includes amyotrophic lateral sclerosis; however, the pathogenic mechanisms that contribute to motor neuron loss remain obscure. Here, we use two induced pluripotent s...
The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons [0.03%]
LRRK2激酶底物RAB8a和RAB10在人神经元中贡献了互补但不同的与疾病相关的表型
Adamantios Mamais,Anwesha Sanyal,Austin Fajfer et al.
Adamantios Mamais et al.
Mutations in the LRRK2 gene cause familial Parkinson's disease presenting with pleomorphic neuropathology that can involve α-synuclein or tau accumulation. LRRK2 mutations are thought to converge upon a pathogenic increase in LRRK2 kinase ...
DeePhys: A machine learning-assisted platform for electrophysiological phenotyping of human neuronal networks [0.03%]
DeePhys：用于人类神经网络电生理分型的机器学习辅助平台
Philipp Hornauer,Gustavo Prack,Nadia Anastasi et al.
Philipp Hornauer et al.
Reproducible functional assays to study in vitro neuronal networks represent an important cornerstone in the quest to develop physiologically relevant cellular models of human diseases. Here, we introduce DeePhys, a MATLAB-based analysis to...