SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss [0.03%]
SALL3介导染色体18q缺失的人类胚胎干细胞神经外胚层分化潜能的丧失
Yingnan Lei,Diana Al Delbany,Nuša Krivec et al.
Yingnan Lei et al.
Human pluripotent stem cell (hPSC) cultures are prone to genetic drift, because cells that have acquired specific genetic abnormalities experience a selective advantage in vitro. These abnormalities are highly recurrent in hPSC lines worldw...
Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants [0.03%]
微图案化iPSC来源的肺泡和气道细胞培养可区分SARS-CoV-2变异毒株
Atsushi Masui,Rina Hashimoto,Yasufumi Matsumura et al.
Atsushi Masui et al.
The emergence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) variants necessitated a rapid evaluation system for their pathogenesis. Lung epithelial cells are their entry points; however, in addition to their limited source...
The histone acetyltransferase KAT6B is required for hematopoietic stem cell development and function [0.03%]
组蛋白乙酰转移酶KAT6B对造血干细胞发育和功能是必需的
Maria I Bergamasco,Nishika Ranathunga,Waruni Abeysekera et al.
Maria I Bergamasco et al.
The histone lysine acetyltransferase KAT6B (MYST4, MORF, QKF) is the target of recurrent chromosomal translocations causing hematological malignancies with poor prognosis. Using Kat6b germline deletion and overexpression in mice, we determi...
Prosaposin maintains adult neural stem cells in a state associated with deep quiescence [0.03%]
prosaposin使成人神经干细胞处于与深层次静息状态相关的一种状态
Miriam Labusch,Melina Thetiot,Emmanuel Than-Trong et al.
Miriam Labusch et al.
In most vertebrates, adult neural stem cells (NSCs) continuously give rise to neurons in discrete brain regions. A critical process for maintaining NSC pools over long periods of time in the adult brain is NSC quiescence, a reversible and t...
Engineering human pluripotent stem cell lines to evade xenogeneic transplantation barriers [0.03%]
工程改造人类多能干细胞系以逃避免疫排斥屏障
Hannah A Pizzato,Paula Alonso-Guallart,James Woods et al.
Hannah A Pizzato et al.
Published Erratum
Stem cell reports. 2024 Apr 9;19(4):596. DOI:10.1016/j.stemcr.2024.03.006 2024
Direct programming of human pluripotent stem cells into endothelial progenitors with SOX17 and FGF2 [0.03%]
SOX17和FGF2直接诱导人多能干细胞向内皮祖细胞分化
Michael W Ream,Lauren N Randolph,Yuqian Jiang et al.
Michael W Ream et al.
Transcription factors (TFs) are pivotal in guiding stem cell behavior, including their maintenance and differentiation. Using single-cell RNA sequencing, we investigated TFs expressed in endothelial progenitors (EPs) derived from human plur...
Restoration of fertility in nonablated recipient mice after spermatogonial stem cell transplantation [0.03%]
输精管干细胞移植后未去除生殖细胞的小鼠的生育能力恢复研究
Hiroko Morimoto,Narumi Ogonuki,Shogo Matoba et al.
Hiroko Morimoto et al.
Spermatogonial stem cell (SSC) transplantation is a valuable tool for studying stem cell-niche interaction. However, the conventional approach requires the removal of endogenous SSCs, causing damage to the niche. Here we introduce WIN18,446...
Osteomacs promote maintenance of murine hematopoiesis through megakaryocyte-induced upregulation of Embigin and CD166 [0.03%]
骨髓基质细胞通过巨核细胞诱导的Embigin和CD166上调维持小鼠造血功能
Safa F Mohamad,Roy El Koussa,Joydeep Ghosh et al.
Safa F Mohamad et al.
Maintenance of hematopoietic stem cell (HSC) function in the niche is an orchestrated event. Osteomacs (OM) are key cellular components of the niche. Previously, we documented that osteoblasts, OM, and megakaryocytes interact to promote hem...
MSX1+PDGFRAlow limb mesenchyme-like cells as an efficient stem cell source for human cartilage regeneration [0.03%]
MSX1+PDGFRAlow 肢体间质样细胞作为人类软骨再生的有效干细胞来源
Yuansong Liao,Fanchen Kang,Jingfei Xiong et al.
Yuansong Liao et al.
Degenerative bone disorders have a significant impact on global health, and regeneration of articular cartilage remains a challenge. Existing cell therapies using mesenchymal stromal cells (MSCs) have shown limited efficacy, highlighting th...
Activated mesenchymal stem/stromal cells promote myeloid cell differentiation via CCL2/CCR2 signaling [0.03%]
激活的间充质干细胞通过CCL2/CCR2信号传导促进髓样细胞分化
Satoshi Yamazaki,Yo Mabuchi,Takaharu Kimura et al.
Satoshi Yamazaki et al.
Myeloid cells, which originate from hematopoietic stem/progenitor cells (HSPCs), play a crucial role in mitigating infections. This study aimed to explore the impact of mesenchymal stem/stromal cells (MSCs) on the differentiation of HSPCs a...