SARS-CoV-2 tropism to intestinal but not gastric epithelial cells is defined by limited ACE2 expression [0.03%]
ACE2表达受限决定SARS-CoV-2趋向肠道而非胃粘膜上皮细胞感染
Mindaugas Paužuolis,Diana Fatykhova,Boris Zühlke et al.
Mindaugas Paužuolis et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection primarily affects the lung but can also cause gastrointestinal (GI) symptoms. In vitro experiments confirmed that SARS-CoV-2 robustly infects intestinal epithelium. Howe...
Survivors of polymicrobial sepsis are refractory to G-CSF-induced emergency myelopoiesis and hematopoietic stem and progenitor cell mobilization [0.03%]
多微生物感染的幸存者对G-CSF诱导的应急髓系细胞生成和造血干细胞及祖细胞动员具有抵抗性
Nirupam Biswas,Amber Bahr,Jennifer Howard et al.
Nirupam Biswas et al.
Sepsis survivors exhibit immune dysfunction, hematological changes, and increased risk of infection. The long-term impacts of sepsis on hematopoiesis were analyzed using a surgical model of murine sepsis, resulting in 50% survival. During a...
MAGIK: A rapid and efficient method to create lineage-specific reporters in human pluripotent stem cells [0.03%]
一种在人类多能干细胞中创建谱系特异性报告基因的快速有效的方法：MAGIK
Tahir Haideri,Jirong Lin,Xiaoping Bao et al.
Tahir Haideri et al.
Precise insertion of fluorescent proteins into lineage-specific genes in human pluripotent stem cells (hPSCs) presents challenges due to low knockin efficiency and difficulties in isolating targeted cells. To overcome these hurdles, we pres...
Single-cell approaches define two groups of mammalian oligodendrocyte precursor cells and their evolution over developmental time [0.03%]
单细胞方法确定了小鼠少突胶质前体细胞的两种类型及其在发育过程中的变化规律
Daniel J Dennis,Beatrix S Wang,Konstantina Karamboulas et al.
Daniel J Dennis et al.
Here, we used single-cell RNA sequencing (scRNA-seq), single-cell ATAC sequencing (scATAC-seq), and single-cell spatial transcriptomics to characterize murine cortical OPCs throughout postnatal life. During development, we identified two gr...
PINK1 deficiency alters muscle stem cell fate decision and muscle regenerative capacity [0.03%]
Pink1缺陷改变肌肉干细胞命运决定和肌肉再生能力
George Cairns,Madhavee Thumiah-Mootoo,Mah Rukh Abbasi et al.
George Cairns et al.
Maintenance of mitochondrial function plays a crucial role in the regulation of muscle stem cell (MuSC), but the underlying mechanisms remain ill defined. In this study, we monitored mitophagy in MuSCS under various myogenic states and exam...
Early neural specification of stem cells is mediated by a set of SOX2-dependent neural-associated enhancers [0.03%]
一套SOX2依赖的神经相关增强子介导干细胞早期的神经谱系分化选择性表达
Pavel Tsaytler,Gaby Blaess,Manuela Scholze-Wittler et al.
Pavel Tsaytler et al.
SOX2 is a transcription factor involved in the regulatory network maintaining the pluripotency of embryonic stem cells in culture as well as in early embryos. In addition, SOX2 plays a pivotal role in neural stem cell formation and neurogen...
Screening of factors inducing alveolar type 1 epithelial cells using human pluripotent stem cells [0.03%]
应用人多能干细胞筛选诱导肺泡Ⅰ型上皮细胞的因素
Yuko Ohnishi,Atsushi Masui,Takahiro Suezawa et al.
Yuko Ohnishi et al.
Alveolar type 2 (AT2) epithelial cells are tissue stem cells capable of differentiating into alveolar type 1 (AT1) cells for injury repair and maintenance of lung homeostasis. However, the factors involved in human AT2-to-AT1 cell different...
MST1/2 regulates fibro/adipogenic progenitor fate decisions in skeletal muscle regeneration [0.03%]
MST1/2在骨骼肌再生中调节成纤维细胞/脂肪生成祖细胞的命运决定
Kezhi Wang,Jingjing Yang,Yina An et al.
Kezhi Wang et al.
Defective skeletal muscle regeneration is often accompanied by fibrosis. Fibroblast/adipose progenitors (FAPs) are important in these processes, however, the regulation of FAP fate decisions is unclear. Here, using inducible conditional kno...
Conclusive demonstration of iatrogenic Alzheimer's disease transmission in a model of stem cell transplantation [0.03%]
干细胞移植模型中确凿证明医源性阿尔茨海默病传染
Chaahat S B Singh,Kelly Marie Johns,Suresh Kari et al.
Chaahat S B Singh et al.
The risk of iatrogenic disease is often underestimated as a concern in contemporary medical procedures, encompassing tissue and organ transplantation, stem cell therapies, blood transfusions, and the administration of blood-derived products...
Patient engagement and satisfaction with early phase cell therapy clinical trials at a tertiary inflammatory bowel disease center [0.03%]
三级炎症性肠病中心早期细胞治疗临床试验的患者参与度和满意度
Megan Obi,Ashley Adams,Alexandria Vandenbossche et al.
Megan Obi et al.
Several clinical trials are underway investigating cell and gene therapy, and while these trials are meant to significantly impact patient care, they rely on patient engagement and participation. Unfortunately, clinical trials generally req...