Targeting mitotic kinesin KIF20A: A differentiation-based therapeutic strategy for glioblastoma stem/progenitor cells [0.03%]
靶向有丝分裂驱动蛋白KIF20A：针对胶质母细胞瘤干细胞/前体细胞的分化治疗策略
Runxiang Qiu,Alejandra Velazquez Ojeda,Cesar Gonzalez et al.
Runxiang Qiu et al.
Glioblastoma multiforme (GBM) remains refractory to current treatment modalities. Differentiation-based approaches, which force cancer stem/progenitor cells to exit the cell cycle and adopt terminal fates, offer an alternative therapeutic s...
Optimized chemogenetic ablation and regeneration of enteric nervous system neurons in zebrafish [0.03%]
优化斑马鱼肠神经系统神经元的化学遗传消融和再生
Mujahid Ali Shah,Katherine K Moran,Helen Rueckert et al.
Mujahid Ali Shah et al.
The enteric nervous system (ENS) is the intrinsic nervous system of the gut and regulates essential functions, including motility. ENS loss is associated with gastrointestinal disorders such as Hirschsprung disease. Restoring missing neuron...
Induction of human pruriceptors from pluripotent stem cells via transcription factors [0.03%]
通过转录因子诱导多能干细胞为人痒觉感受器
Hisato Iriki,Ruiqi Hu,Xu Li et al.
Hisato Iriki et al.
Pruriception is crucial for defense against external stimuli but can lead to chronic pruritus, a debilitating condition affecting millions worldwide. Our understanding of the cellular and molecular mechanisms behind the sensation of itch ha...
Identification of novel genes with enriched expression in human intermediate progenitors reveals a key role for CDKN3 in cortical development [0.03%]
鉴定出新型的在人的中间前体中富含表达的基因揭示了CDKN3在皮层发育中的关键作用
Pauline Antonie Ulmke,Martin N Ivanov,Hoang Duy Nguyen et al.
Pauline Antonie Ulmke et al.
The evolutionary expansion of the human neocortex relies on species-specific features of intermediate progenitor cells (IPCs), including enhanced proliferation and neuronal production. The transcriptomic differences in IPCs underlying their...
In silico optimization of regenerative cell therapy in the infarcted human ventricles to mitigate arrhythmic burden [0.03%]
模拟优化再生细胞治疗在人类心室梗死中的应用以减轻心律失常负担
Leto Luana Riebel,Zhinuo Jenny Wang,Xin Zhou et al.
Leto Luana Riebel et al.
Myocardial infarction remains a frequent cause of heart failure and mortality. Cell therapy has shown promise in regenerating the damaged tissue, but delivered cells may beat spontaneously and produce ventricular arrhythmias, hindering clin...
Topical vascular organoid therapy promotes microvascular regeneration and functional recovery in porcine ischemic cardiomyopathy [0.03%]
用于促进猪缺血性心肌病微血管再生和功能恢复的拓扑血管器官疗法
John A Farag,Shin Yajima,Yujiro Kawai et al.
John A Farag et al.
Ischemic heart disease (IHD) often progresses to heart failure due to persistent microvascular dysfunction not corrected by conventional epicardial revascularization. We developed a scaffold-free vascular organoid composed of human endothel...
The role of gastric cancer patient-derived organoids in precision medicine: Clinicians' perspective [0.03%]
胃癌患者来源类器官在精准医学中的作用：临床医生的视角
Tharindie N Silva,Harleen Kaur,Tharani Krishnan et al.
Tharindie N Silva et al.
Organoid technology holds great potential and hope for personalized treatment in gastric cancer (GC). To date, clinicians' views on this technology for precision oncology have not been reported despite these insights being invaluable to und...
GLP-1 regulates osteo-adipogenic fate of BMSCs via HIF-2-AKT signaling and supports trabecular bone in glucocorticoid-induced osteoporosis [0.03%]
GLP-1通过HIF-2-Akt信号通路调节骨髓间充质干细胞成软骨/成脂肪分化并支持皮质骨防治糖皮质激素诱导的骨质疏松症
Zhe Yang,Xin Li,Niujian Wu et al.
Zhe Yang et al.
Bone marrow mesenchymal stem cell (BMSC) lineage commitment contributes to metabolic bone diseases, but whether glucagon-like peptide-1 (GLP-1) regulates osteo-adipogenic fate remains unclear. Here, RNA sequencing was performed to identify ...
PRDM16 modulates aspects of cell cycle dynamics and maturation in human iPSC-derived cardiomyocytes [0.03%]
PRDM16调控人多能干细胞源心肌细胞的增殖和分化成熟部分表型
Kanae Tani,Yasuko Matsumura,Misato Nishikawa et al.
Kanae Tani et al.
Deciphering how cardiomyocytes exit proliferation and acquire postnatal maturity is essential for understanding heart development and regenerative potential. We identify PRDM16 as a regulator that influences the balance between proliferatio...
Allogeneic islet products for type 1 diabetes: Navigating nonclinical and manufacturing regulatory expectations [0.03%]
同种异体胰岛产品用于治疗1型糖尿病：如何应对非临床和制造监管期望
Chengyuan Press,Kevin D&#x;Amour,Nicholas Mamrak et al.
Chengyuan Press et al.
Next-generation allogeneic islet cell products-including stem cell (SC)-derived, gene-edited, and encapsulated islets-offer scalable and curative solutions to restore physiological glucose control in type 1 diabetes. The critical path to su...