Skeletal muscle-on-a-chip in microgravity as a platform for regeneration modeling and drug screening [0.03%]
体外培养的骨骼肌芯片在微重力下的再生模型及药物筛选中的应用
Soochi Kim,Bugra Ayan,Mahdis Shayan et al.
Soochi Kim et al.
Microgravity has been shown to lead to both muscle atrophy and impaired muscle regeneration. The purpose was to study the efficacy of microgravity to model impaired muscle regeneration in an engineered muscle platform and then to demonstrat...
Advanced human embryo research beyond the 14-day limit: A bioethical perspective from the Muslim world [0.03%]
超越14天限制的人类胚胎研究：来自穆斯林世界的生命伦理学观点
Mohammed Ghaly,Essam M Abdelalim
Mohammed Ghaly
Advancements in in vitro human embryo research prompt a reconsideration of the 14-day rule, highlighting the integration of global religious perspectives, particularly Islam. Through analyzing classical Muslim scholars' perspectives and mod...
Qi Zhang,Yanfang Wang,Zhenan Bu et al.
Qi Zhang et al.
The Ras family genes are proto-oncogenes that are highly conserved from Drosophila to humans. In Drosophila, RasV12 is a constitutively activated form of the Ras oncoprotein, and its function in cell-cycle progression is context dependent. ...
JAK/STAT signaling promotes the emergence of unique cell states in ulcerative colitis [0.03%]
JAK/STAT信号促进溃疡性结肠炎中独特细胞状态的出现
Grzegorz Maciag,Stine Lind Hansen,Kata Krizic et al.
Grzegorz Maciag et al.
The intestinal epithelium ensures uptake of vital nutrients and acts as a barrier between luminal contents and the underlying immune system. In inflammatory bowel diseases, such as ulcerative colitis (UC), this barrier is compromised, and p...
Imen F Alkuraya,Edward B De Vol
Imen F Alkuraya
The effect of consanguinity on identifying universal induced pluripotent stem cell (iPSC) donors, i.e., homozygous for the major human leukocyte antigen (HLA) loci, is unknown. The discovery sample size was calculated in a consanguineous po...
Feeder-free culture of human pluripotent stem cells drives MDM4-mediated gain of chromosome 1q [0.03%]
无 feeder 细胞的人类多能干细胞培养通过MDM4介导的获得性染色体1q增多导致遗传改变
Dylan Stavish,Christopher J Price,Gabriele Gelezauskaite et al.
Dylan Stavish et al.
Culture-acquired variants in human pluripotent stem cells (hPSCs) hinder their applications in research and clinic. However, the mechanisms that underpin selection of variants remain unclear. Here, through analysis of comprehensive karyotyp...
Retinal cells derived from patients with DRAM2-dependent CORD21 dystrophy exhibit key lysosomal enzyme deficiency and lysosomal content accumulation [0.03%]
DRAM2依赖的CORD21患者的视网膜细胞表现出关键溶酶体酶缺陷和溶酶体内容物积累
Rozaliya Tsikandelova,Eldo Galo,Edvinas Cerniauskas et al.
Rozaliya Tsikandelova et al.
Biallelic mutations in DRAM2 lead to an autosomal recessive cone-rod dystrophy known as CORD21, which typically presents between the third and sixth decades of life. Although DRAM2 localizes to the lysosomes of photoreceptor and retinal pig...
Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility [0.03%]
用于微生理系统质量管理和监测其重现性的因体适用性标准的建议
David Pamies,Jason Ekert,Marie-Gabrielle Zurich et al.
David Pamies et al.
Published Erratum
Stem cell reports. 2024 Jul 2;19(7):1041. DOI:10.1016/j.stemcr.2024.06.007 2024
TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting Wnt and BMP signaling [0.03%]
TGF-β通过抑制Wnt和BMP信号调控人ES细胞来源的前肠内胚层中的细胞命运
Nina Sofi Funa,Heidi Katharina Mjoseng,Kristian Honnens de Lichtenberg et al.
Nina Sofi Funa et al.
Genetic differences between pluripotent stem cell lines cause variable activity of extracellular signaling pathways, limiting reproducibility of directed differentiation protocols. Here we used human embryonic stem cells (hESCs) to interrog...
Deciphering the heterogeneity of differentiating hPSC-derived corneal limbal stem cells through single-cell RNA sequencing [0.03%]
通过单细胞RNA测序解读人多能干细胞源性角膜缘干细胞异质性
Meri Vattulainen,Jos G A Smits,Julian A Arts et al.
Meri Vattulainen et al.
A comprehensive understanding of the human pluripotent stem cell (hPSC) differentiation process stands as a prerequisite for the development of hPSC-based therapeutics. In this study, single-cell RNA sequencing (scRNA-seq) was performed to ...