EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner [0.03%]
EZH2通过MELK/FOXM1依赖性方式保护胶质瘤干细胞免受放射诱导的细胞死亡
Sung-Hak Kim,Kaushal Joshi,Ravesanker Ezhilarasan et al.
Sung-Hak Kim et al.
Breaking the burst: Unveiling mechanisms behind fragmented network bursts in patient-derived neurons [0.03%]
破解爆发：揭示患者衍生神经元中碎片化网络爆发的机制
Nina Doorn,Eva J H F Voogd,Marloes R Levers et al.
Nina Doorn et al.
Fragmented network bursts (NBs) are observed as a phenotypic driver in many patient-derived neuronal networks on multi-electrode arrays (MEAs), but the pathophysiological mechanisms underlying this phenomenon are unknown. Here, we used our ...
Transplantation of human pluripotent stem cell-derived retinal sheet in a primate model of macular hole [0.03%]
人多能干细胞来源视网膜类器官片层移植至灵长类黄斑孔模型中
Yasuaki Iwama,Yasuko Sugase-Miyamoto,Kenta Onoue et al.
Yasuaki Iwama et al.
Macular hole (MH) is a retinal break involving the fovea that causes impaired vision. Although advances in vitreoretinal surgical techniques achieve >90% MH closure rate, refractory cases still exist. For such cases, autologous retinal tran...
SMAD3 mediates the specification of human induced pluripotent stem cell-derived epicardium into progenitors for the cardiac pericyte lineage [0.03%]
SMAD3介导人诱导多能干细胞源性的心外膜细胞分化成心脏周细胞谱系的前体细胞
Yutaro Miyoshi,Antonio Lucena-Cacace,Yu Tian et al.
Yutaro Miyoshi et al.
Understanding the molecular mechanisms of epicardial epithelial-to-mesenchymal transition (EMT), particularly in directing cell fate toward epicardial derivatives, is crucial for regenerative medicine using human induced pluripotent stem ce...
Abnormal synaptic architecture in iPSC-derived neurons from a multi-generational family with genetic Creutzfeldt-Jakob disease [0.03%]
遗传性克雅病家系诱导 pluripotent干细胞神经元突触结构异常
Aldana D Gojanovich,Nhat T T Le,Robert C C Mercer et al.
Aldana D Gojanovich et al.
Genetic prion diseases are caused by mutations in PRNP, which encodes the prion protein (PrPC). Why these mutations are pathogenic, and how they alter the properties of PrPC are poorly understood. We have consented and accessed 22 individua...
Functionally redundant roles of ID family proteins in spermatogonial stem cells [0.03%]
ID家族蛋白在 spermatogonial干细胞中的功能冗余作用
Hue M La,Ai-Leen Chan,Ashlee M Hutchinson et al.
Hue M La et al.
Spermatogonial stem cells (SSCs) are essential for sustained sperm production, but SSC regulatory mechanisms and markers remain poorly defined. Studies have suggested that the Id family transcriptional regulator Id4 is expressed in SSCs and...
Guidelines for managing and using the digital phenotypes of pluripotent stem cell lines [0.03%]
诱导多能干细胞系的数字表型管理与应用指南
Christine A Wells,Anke Guhr,Amos Bairoch et al.
Christine A Wells et al.
Each pluripotent stem cell line has a physical entity as well as a digital phenotype, but linking the two unambiguously is confounded by poor naming practices and assumed knowledge. Registration gives each line a unique and persistent ident...
Rod-shaped micropatterning enhances the electrophysiological maturation of cardiomyocytes derived from human induced pluripotent stem cells [0.03%]
棒状微图案促进由人类诱导多能干细胞衍生的心肌细胞的电生理成熟
Zeina R Al Sayed,Charlène Jouve,Magali Seguret et al.
Zeina R Al Sayed et al.
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offer great potential for drug screening and disease modeling. However, hiPSC-CMs remain immature compared to the adult cardiac cells. Cardiomyocytes isolated from adult...
Dynamic spatiotemporal activation of a pervasive neurogenic competence in striatal astrocytes supports continuous neurogenesis following injury [0.03%]
纹状体星形胶质细胞的动态时空激活支持损伤后的连续神经发生
Marco Fogli,Giulia Nato,Philip Greulich et al.
Marco Fogli et al.
Adult neural stem cells (NSCs) are conventionally regarded as rare cells restricted to two niches: the subventricular zone (SVZ) and the subgranular zone. Parenchymal astrocytes (ASs) can also contribute to neurogenesis after injury; howeve...
Astrocytes originated from neural stem cells drive the regenerative remodeling of pathologic CSPGs in spinal cord injury [0.03%]
神经干细胞来源的星形胶质细胞驱动脊髓损伤后病理性硫酸软骨素的再生重塑
Seyed Mojtaba Hosseini,Shiva Nemati,Soheila Karimi-Abdolrezaee
Seyed Mojtaba Hosseini
Neural degeneration is a hallmark of spinal cord injury (SCI). Multipotent neural precursor cells (NPCs) have the potential to reconstruct the damaged neuron-glia network due to their tri-lineage capacity to generate neurons, astrocytes, an...