Interleukin-1β induces trained innate immunity in human hematopoietic progenitor cells in vitro [0.03%]
人造血祖细胞体外培养中白介素-1β诱导训练免疫反应
Daniela Flores-Gomez,Willemijn Hobo,Diede van Ens et al.
Daniela Flores-Gomez et al.
Innate immune cells can develop a long-lasting hyperresponsive phenotype, termed trained immunity, mediated by epigenetic and metabolic reprogramming. In mice, exposure to Bacille Calmette-Guérin (BCG), β-glucan, or Western diet induces t...
Derivation of transplantable human thyroid follicular epithelial cells from induced pluripotent stem cells [0.03%]
人诱导多能干细胞向移植性甲状腺滤泡上皮细胞的分化
Hendrik J Undeutsch,Alberto Posabella,Andrea B Alber et al.
Hendrik J Undeutsch et al.
The production of mature functioning thyroid follicular cells (TFCs) from human induced pluripotent stem cells (iPSCs) is critical for potential novel therapeutic approaches to post-surgical and congenital hypothyroidism. To accomplish this...
Genome-wide screening reveals essential roles for HOX genes and imprinted genes during caudal neurogenesis of human embryonic stem cells [0.03%]
全基因组筛选揭示HOX基因和印记基因在人胚胎干细胞尾侧神经发生过程中的重要作用
Shay Kinreich,Anna Bialer-Tsypin,Ruth Viner-Breuer et al.
Shay Kinreich et al.
Mapping the essential pathways for neuronal differentiation can uncover new therapeutics and models for neurodevelopmental disorders. We thus utilized a genome-wide loss-of-function library in haploid human embryonic stem cells, differentia...
Neural crest precursors from the skin are the primary source of directly reprogrammed neurons [0.03%]
皮肤神经嵴前体细胞是直接重编程神经元的主要来源
Justin J Belair-Hickey,Ahmed Fahmy,Wenbo Zhang et al.
Justin J Belair-Hickey et al.
Direct reprogramming involves the conversion of differentiated cell types without returning to an earlier developmental state. Here, we explore how heterogeneity in developmental lineage and maturity of the starting cell population contribu...
Lineage-specific dynamics of loss of X upregulation during inactive-X reactivation [0.03%]
特异性谱系的失活X染色体重新激活过程中的失活X丢失动态
Hemant Chandru Naik,Deepshikha Chandel,Sudeshna Majumdar et al.
Hemant Chandru Naik et al.
In mammals, X chromosome dosage is balanced between sexes through the silencing of one X chromosome in females. Recent single-cell RNA sequencing analysis demonstrated that the inactivation of the X chromosome is accompanied by the upregula...
Bo Li
Bo Li
Calvarial bones safeguard the brain and are interconnected by immovable joints termed sutures, which function as growth centers for skull morphogenesis and stem cell niches. Recent years have witnessed paradigm shifts in this field, highlig...
The urgent need for clear and concise regulations on exosome-based interventions [0.03%]
关于基于外体的干预措施清晰简洁规范的紧迫需求
Misao Fujita,Taichi Hatta,Tsunakuni Ikka et al.
Misao Fujita et al.
Turner and colleagues recently argued that countries with unclear laws and regulations regarding stem cells, exosomes, and other regenerative medicine products should develop and enforce more comprehensive regulatory structures. We fully ag...
Targeting glioblastoma with a brain-penetrant drug that impairs brain tumor stem cells via NLE1-Notch1 complex [0.03%]
靶向胶质母细胞瘤的脑渗透药物通过NLE1-Notch1复合物破坏脑肿瘤干细胞
Audrey Burban,Ahmad Sharanek,Aldo Hernandez-Corchado et al.
Audrey Burban et al.
Brain tumor stem cells (BTSCs) are a population of self-renewing malignant stem cells that play an important role in glioblastoma tumor hierarchy and contribute to tumor growth, therapeutic resistance, and tumor relapse. Thus, targeting of ...
Validation of non-destructive morphology-based selection of cerebral cortical organoids by paired morphological and single-cell RNA-seq analyses [0.03%]
基于非破坏性形态选择脑皮层类器官的验证：结合形态学和单细胞RNA测序分析配对研究
Megumi Ikeda,Daisuke Doi,Hayao Ebise et al.
Megumi Ikeda et al.
Organoids, self-organized cell aggregates, contribute significantly to developing disease models and cell-based therapies. Organoid-to-organoid variations, however, are inevitable despite the use of the latest differentiation protocols. Her...
Zhaoran Zhang,Junru Miao,Hanben Wang et al.
Zhaoran Zhang et al.
At different stages of spermatogenesis, germ cell mitochondria differ remarkably in morphology, architecture, and functions. However, it remains elusive how mitochondria change their features during spermatogonial differentiation, which in ...