Sustained Activation of AMPK Enhances Differentiation of Human iPSC-Derived Cardiomyocytes via Sirtuin Activation [0.03%]
AMPK的持续激活可通过Sirtuin活化增强人多能干细胞源心肌细胞分化
Mohsen Sarikhani,Jessica C Garbern,Sai Ma et al.
Mohsen Sarikhani et al.
Recent studies suggest that metabolic regulation may improve differentiation of cardiomyocytes derived from induced pluripotent stem cells (iPSCs). AMP-activated protein kinase (AMPK) is a master regulator of metabolic activities. We invest...
A Novel GATA2 Protein Reporter Mouse Reveals Hematopoietic Progenitor Cell Types [0.03%]
一种新型GATA2蛋白质报告小鼠揭示了造血祖细胞类型
Nouraiz Ahmed,Leo Kunz,Philipp S Hoppe et al.
Nouraiz Ahmed et al.
The transcription factor (TF) GATA2 plays a key role in organ development and cell fate control in the central nervous, urogenital, respiratory, and reproductive systems, and in primitive and definitive hematopoiesis. Here, we generate a kn...
Induced Fetal Human Muscle Stem Cells with High Therapeutic Potential in a Mouse Muscular Dystrophy Model [0.03%]
在小鼠肌肉营养不良模型中具有高度治疗潜力的诱导胎盘人类肌肉干细胞
Mingming Zhao,Atsutoshi Tazumi,Satoru Takayama et al.
Mingming Zhao et al.
Duchenne muscular dystrophy (DMD) is a progressive and fatal muscle-wasting disease caused by DYSTROPHIN deficiency. Cell therapy using muscle stem cells (MuSCs) is a potential cure. Here, we report a differentiation method to generate feta...
A Rainbow Reporter Tracks Single Cells and Reveals Heterogeneous Cellular Dynamics among Pluripotent Stem Cells and Their Differentiated Derivatives [0.03%]
单细胞追踪及揭示多能干细胞及其分化后代的异质性细胞动力学
Danny El-Nachef,Kevin Shi,Kevin M Beussman et al.
Danny El-Nachef et al.
Single-cell transcriptomic approaches have found molecular heterogeneities within populations of pluripotent stem cells (PSCs). A tool that tracks single-cell lineages and their phenotypes longitudinally would reveal whether heterogeneity e...
Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome [0.03%]
人胚胎干细胞可以分化形成具有滋养层表型和甲基化特征的细胞类型
Jessica K Cinkornpumin,Sin Young Kwon,Yixin Guo et al.
Jessica K Cinkornpumin et al.
Human embryonic stem cells (hESCs) readily differentiate to somatic or germ lineages but have impaired ability to form extra-embryonic lineages such as placenta or yolk sac. Here, we demonstrate that naive hESCs can be converted into cells ...
A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells [0.03%]
一个高度表型的抗胰蛋白酶缺乏症多能干细胞开放访问库
Joseph E Kaserman,Killian Hurley,Mark Dodge et al.
Joseph E Kaserman et al.
Individuals with the genetic disorder alpha-1 antitrypsin deficiency (AATD) are at risk of developing lung and liver disease. Patient induced pluripotent stem cells (iPSCs) have been found to model features of AATD pathogenesis but only a h...
Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies [0.03%]
人多能干细胞来源的海马球状体：一种用于阿尔茨海默病患者特异性细胞表型分层和开发疗法的创新工具
Yuriy Pomeshchik,Oxana Klementieva,Jeovanis Gil et al.
Yuriy Pomeshchik et al.
The hippocampus is important for memory formation and is severely affected in the brain with Alzheimer disease (AD). Our understanding of early pathogenic processes occurring in hippocampi in AD is limited due to tissue unavailability. Here...
Survey Says: "COVID-19 Lockdown Hits Young Faculty and Clinical Trials" [0.03%]
调查表明：“新冠疫情封锁影响青年教师和临床试验”
David G Kent,David J H F Knapp,Nagarajan Kannan
David G Kent
COVID-19 has severely impacted laboratory research. Analysis of the International Society for Stem Cell Research (ISSCR) member survey has highlighted a particular impact on clinical trials and early-career investigators. The stem cell comm...
In Vitro Differentiated Human Stem Cell-Derived Neurons Reproduce Synaptic Synchronicity Arising during Neurodevelopment [0.03%]
人诱导多能干细胞来源的神经元体外分化可重现发育中的神经同步性
Filip Rosa,Ashutosh Dhingra,Betül Uysal et al.
Filip Rosa et al.
Neurons differentiated from induced pluripotent stem cells (iPSCs) typically show regular spiking and synaptic activity but lack more complex network activity critical for brain development, such as periodic depolarizations including simult...
Transplantation of Skin Precursor-Derived Schwann Cells Yields Better Locomotor Outcomes and Reduces Bladder Pathology in Rats with Chronic Spinal Cord Injury [0.03%]
脊髓损伤恒河猴中，皮肤源前体细胞来源的施万细胞移植产生更优运动功能恢复和减少膀胱病理损害
Peggy Assinck,Joseph S Sparling,Shaalee Dworski et al.
Peggy Assinck et al.
Cell transplantation for spinal cord injury (SCI) has largely been studied in sub-acute settings within 1-2 weeks of injury. In contrast, here we transplanted skin-derived precursors differentiated into Schwann cells (SKP-SCs) into the cont...