Megakaryocyte progenitor cell function is enhanced upon aging despite the functional decline of aged hematopoietic stem cells [0.03%]
巨核系祖细胞功能随衰老增强尽管骨髓造血干细胞功能随衰老退化
Donna M Poscablo,Atesh K Worthington,Stephanie Smith-Berdan et al.
Donna M Poscablo et al.
Age-related morbidity is associated with a decline in hematopoietic stem cell (HSC) function, but the mechanisms of HSC aging remain unclear. We performed heterochronic HSC transplants followed by quantitative analysis of cell reconstitutio...
Study of inherited thrombocytopenia resulting from mutations in ETV6 or RUNX1 using a human pluripotent stem cell model [0.03%]
利用人类多能干细胞模型研究ETV6或RUNX1突变引起的遗传性血小板减少症
Sara Borst,Catriana C Nations,Joshua G Klein et al.
Sara Borst et al.
Inherited thrombocytopenia results in low platelet counts and increased bleeding. Subsets of these patients have monoallelic germline mutations in ETV6 or RUNX1 and a heightened risk of developing hematologic malignancies. Utilizing CRISPR-...
Human iPSC-based neurodevelopmental models of globoid cell leukodystrophy uncover patient- and cell type-specific disease phenotypes [0.03%]
基于人诱导多能干细胞的格洛布赛尔细胞白质消减症神经发育模型发现患者和细胞类型特异性的疾病表型
Elisabeth Mangiameli,Anna Cecchele,Francesco Morena et al.
Elisabeth Mangiameli et al.
Globoid cell leukodystrophy (GLD) is a rare neurodegenerative lysosomal storage disease caused by an inherited deficiency of β-galactocerebrosidase (GALC). GLD pathogenesis and therapeutic correction have been poorly studied in patient neu...
Updates for contributors: Rigor and reproducibility in stem cell research [0.03%]
致投稿作者：干细胞研究的严谨性和可重复性
Martin Pera
Martin Pera
An integrated analysis of human myeloid cells identifies gaps in in vitro models of in vivo biology [0.03%]
对体内生物学的体外模型进行整合分析以寻找不足之处：髓系细胞案例研究
Nadia Rajab,Paul W Angel,Yidi Deng et al.
Nadia Rajab et al.
The Stemformatics myeloid atlas is an integrated transcriptome atlas of human macrophages and dendritic cells that systematically compares freshly isolated tissue-resident, cultured, and pluripotent stem cell-derived myeloid cells. Three cl...
Comparative Study
Stem cell reports. 2021 Jun 8;16(6):1629-1643. DOI:10.1016/j.stemcr.2021.04.010 2021
Agarose microgel culture delineates lumenogenesis in naive and primed human pluripotent stem cells [0.03%]
琼胶微凝胶培养法可区分原始和启动的人多能干细胞的腔形成能力
Magdalena Schindler,Dylan Siriwardena,Timo N Kohler et al.
Magdalena Schindler et al.
Human periimplantation development requires the transformation of the naive pluripotent epiblast into a polarized epithelium. Lumenogenesis plays a critical role in this process, as the epiblast undergoes rosette formation and lumen expansi...
Deep neural net tracking of human pluripotent stem cells reveals intrinsic behaviors directing morphogenesis [0.03%]
深度神经网络追踪人类多能干细胞揭示了调控形态发生的内在行为
David A Joy,Ashley R G Libby,Todd C McDevitt
David A Joy
Lineage tracing is a powerful tool in developmental biology to interrogate the evolution of tissue formation, but the dense, three-dimensional nature of tissue limits the assembly of individual cell trajectories into complete reconstruction...
Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2 [0.03%]
红系前体细胞和祖细胞抑制适应性免疫并被SARS-CoV-2感染
Shima Shahbaz,Lai Xu,Mohammed Osman et al.
Shima Shahbaz et al.
SARS-CoV-2 infection is associated with lower blood oxygen levels, even in patients without hypoxia requiring hospitalization. This discordance illustrates the need for a more unifying explanation as to whether SARS-CoV-2 directly or indire...
Courtney L McMahon,Hilary Staples,Michal Gazi et al.
Courtney L McMahon et al.
Coronavirus disease 2019 (COVID-19) patients have manifested a variety of neurological complications, and there is still much to reveal regarding the neurotropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human stem c...
SnapShot: Embryo models [0.03%]
SnapShot：胚胎模型
Nicolas Rivron,Jianping Fu
Nicolas Rivron