Integrated stress response-mediated metabolic reprogramming drives hepatic stellate cell activation and liver fibrosis via the noncanonical EIF3d-ATF4-S100P signaling pathway [0.03%]
整合应激反应介导的代谢重编程通过非经典的EIF3d-ATF4-S100P信号通路驱动肝星状细胞活化和肝纤维化
Simin Yang,Hongli Zhang,Xiaoyan Sun et al.
Simin Yang et al.
Hepatic stellate cells (HSCs) trans-differentiation into myofibroblasts is central to liver fibrosis. Integrated stress response (ISR) signaling, including metabolic stress, plays a critical role in this process. However, the precise role o...
Natural compounds modulating redox metabolism and Inflammation: New insights in skin cancer prevention and therapy [0.03%]
调节氧化代谢和炎症的天然化合物：皮肤癌预防和治疗的新视角
Sinemyiz Atalay Ekiner,Agnieszka Gęgotek,Elżbieta Skrzydlewska
Sinemyiz Atalay Ekiner
UV radiation penetrating human skin causes DNA damages, including specific mutations, redox imbalances, oxidative damage to macromolecules, and consequently changes in intracellular signaling pathways, particularly those involved in inflamm...
Oxidation of hemoglobin to ferryl hemoglobin contributes to remodeling of the artery wall in abdominal aortic aneurysm [0.03%]
血红蛋白氧化成高铁血红蛋白参与腹主动脉瘤动脉壁重构的过程
Yuchao Ding,László Potor,Éva Katona et al.
Yuchao Ding et al.
Abdominal aortic aneurysm (AAA) with potentially fatal outcomes affects cardiovascular health via inflammation-related abnormalities. We revealed the presence of the oxidized hemoglobin (Hb), ferrylHb in the circulation in patients diagnose...
Huiting Xu,Yang Liu,Tiandong Chen et al.
Huiting Xu et al.
Long regarded as a toxic substance, hydrogen sulfide (H2S) is now recognized as an essential gaseous signaling molecule that demonstrates dual modulation capacities in biological regulation and disease progression. Contemporary research del...
Nitrate maintains mitochondrial membrane integrity by increasing Sialin-FKBP8 granules via liquid-liquid-phase separation [0.03%]
硝酸盐通过液-液相分离增加Sialin-FKBP8颗粒以维持线粒体膜的完整性的研究
Xue Wang,Huan Liu,Minwei Yue et al.
Xue Wang et al.
Mitochondria, the metabolic centers of cells, play a pivotal role in maintaining cellular homeostasis and regulating physiological processes. Mitochondrial membrane disruption and consequent dysfunction are key pathogenic mechanisms underly...
KEAP1 C151 active site catalysis drives electrophilic signaling to upregulate cytoprotective enzyme expression [0.03%]
KEAP1 C151活性位点催化驱动亲电子信号传导以上调细胞保护酶的表达
Matthew R Schnell,Tianhua Zhai,Edwin R Ragwan et al.
Matthew R Schnell et al.
Cells mount a detoxification, antioxidant, and anti-inflammatory response to electrophiles, mediated by the NRF2 transcription factor. Electrophilic NRF2 activators are used to treat diverse chronic diseases. While the majority of NRF2 acti...
Mitochondrial transplant: Unravelling a promising treatment for ocular diseases [0.03%]
线粒体移植：揭开眼科疾病的潜在治疗方法
Yan Zhuang Yeo,Mayuri Bhargava,Rajvinder Singh Khare et al.
Yan Zhuang Yeo et al.
Mitochondrial transplantation is an upcoming therapeutic modality where transfer of healthy robust mitochondria bio-enhances metabolically dysfunctional cells or tissues. Though the concept of MT germinated in early 1980s in a bid to develo...
Geniposide, a potential therapeutical candidate for acute pancreatitis, inhibited trypsinogen-activated CBS degradation and remodeled transsulfuration metabolic flux [0.03%]
京尼平通过抑制胰蛋白酶激活的CBS降解及重塑交联硫代谢通量，有望成为急性胰腺炎治疗的新候选药物
Ji Gao,Yijing Long,Jiawang Li et al.
Ji Gao et al.
Acute pancreatitis (AP) is a potentially fatal condition with no targeted treatment options currently available. The premature activation of trypsinogen within acinar cells constitutes one of the pivotal early pathological events in AP, con...
S-nitrosylation of paired-related homeobox 1 promotes cardiac remodeling following myocardial infarction [0.03%]
paired样homeobox 1蛋白S-硝基化促进心肌梗死后的心脏重塑
Dashuai Wang,Shaoxuan Zhou,Yajing Tang et al.
Dashuai Wang et al.
Backgrounds: Cardiac remodeling, mediated by fibroblast-to-myofibroblast differentiation, is a key pathophysiologic step to determine the prognosis of patients following myocardial infarction (MI). Paired-related homeobox...
Corrigendum to "Folate alleviated skin inflammation and fibrosis resulting from impaired homocysteine metabolism" [Redox Biol. 80 (2025) 103501] [0.03%]
关于“ folate alleviated skin inflammation and fibrosis resulting from impaired homocysteine metabolism”的勘误（红氧生物学80卷103501号）
Jiefeng Huang,Wuyan Lu,Shenli Zhao et al.
Jiefeng Huang et al.
Published Erratum
Redox biology. 2025 Oct 29:103904. DOI:10.1016/j.redox.2025.103904 2025